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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2008

Open Access 01-12-2008 | Review

Central tolerance: what have we learned from mice?

Authors: Tom M. McCaughtry, Kristin A. Hogquist

Published in: Seminars in Immunopathology | Issue 4/2008

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Abstract

Producing a healthy immune system capable of defending against pathogens, while avoiding autoimmunity, is dependent on thymic selection. Positive selection yields functional T cells that have the potential to recognize both self and foreign antigens. Therefore, negative selection exists to manage potentially self-reactive cells. Negative selection results from the induction of anergy, receptor editing, clonal diversion (agonist selection), and/or clonal deletion (apoptosis) in self-reactive clones. Clonal deletion has been inherently difficult to study because the cells of interest are undergoing apoptosis and being eliminated quickly. Furthermore, analysis of clonal deletion in humans has proved even more difficult due to availability of samples and lack of reagents. Mouse models have thus been instrumental in achieving our current understanding of central tolerance, and the evolution of elegant model systems has led to an explosion of new data to be assimilated. This review will focus on recent advances in the field of clonal deletion with respect to three aspects: the development of physiological model systems, signaling pathways that lead to apoptosis, and antigen presenting cell types involved in the induction of clonal deletion.
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Metadata
Title
Central tolerance: what have we learned from mice?
Authors
Tom M. McCaughtry
Kristin A. Hogquist
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 4/2008
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-008-0137-0

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