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01-12-2008 | Review

Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development

Authors: Tom Taghon, Ellen V. Rothenberg

Published in: Seminars in Immunopathology | Issue 4/2008

Abstract

Following specification of hematopoietic precursor cells into the T cell lineage, several developmental options remain available to the immature thymocytes. The paradigm is that the outcome of the T cell receptor rearrangements and the corresponding T cell receptor signaling events will be predominant to determine the first of these choices: the αβ versus γδ T cell pathways. Here, we review the thymus-derived environmental signals, the transcriptional mediators, and other molecular mechanisms that are also involved in this decision in both the mouse and human. We discuss the differences in cellular events between the αβ and γδ developmental pathways and try to correlate these with a corresponding complexity of the molecular mechanisms that support them.

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Title: Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development
Authors: Tom Taghon
Ellen V. Rothenberg
Publication date: 01-12-2008
Publisher: Springer-Verlag
Published in: Seminars in Immunopathology / Issue 4/2008
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-008-0134-3

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Molecular mechanisms that control mouse and human TCR-αβ and TCR-γδ T cell development

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