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Seminars in Immunopathology
Published in: Seminars in Immunopathology 3/2005

01-01-2005 | Original Article

Induction of antigen cross-presentation by Toll-like receptors

Authors: Sandip K. Datta, Eyal Raz

Published in: Seminars in Immunopathology | Issue 3/2005

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Abstract

Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8+ T cells. This pathway is important for the development of CD8+ cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8+ T cell activation and implementing novel vaccine strategies is considered.
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Metadata
Title
Induction of antigen cross-presentation by Toll-like receptors
Authors
Sandip K. Datta
Eyal Raz
Publication date
01-01-2005
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 3/2005
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-004-0174-2

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