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01-08-2019 | Chronic Myeloid Leukemia | Original Article

Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice

Authors: Giovanni Caocci, Olga Mulas, Elisabetta Abruzzese, Alessandra Iurlo, Mario Annunziata, Ester Maria Orlandi, Sara Galimberti, Gianni Binotto, Nicola Sgherza, Luigia Luciano, Bruno Martino, Antonella Russo Rossi, Massimiliano Bonifacio, Claudio Fozza, Malgorzata Monika Trawinska, Daniele Cattaneo, Chiara Elena, Claudia Baratè, Fiorenza De Gregorio, Matteo Molica, Giorgio La Nasa, Robin Foà, Massimo Breccia

Published in: Annals of Hematology | Issue 8/2019

Abstract

There is little information about cardiovascular adverse event (CV-AE) incidence in chronic myeloid leukemia (CML) patients treated with bosutinib in the real-life practice. We identified 54 consecutive CML patients treated with bosutinib, stratified according to the Systematic Coronary Risk Evaluation (SCORE) assessment, based on sex, age, smoking habits, systolic blood pressure, and total cholesterol levels. The 40-month cumulative incidence of CV-AEs was 25.2 ± 8.1%. Patients with the SCORE of high–very high showed a significantly higher incidence of CV-AEs (55 ± 12.9% vs 9 ± 9.5%; p = 0.002). Overall, 9 CV-AEs were reported, with 2 deaths attributed to CV-AE. In conclusion, the SCORE assessment before starting treatment is helpful in identifying CV-AE high-risk patients during bosutinib treatment.

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Title: Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice
Authors: Giovanni Caocci
Olga Mulas
Elisabetta Abruzzese
Alessandra Iurlo
Mario Annunziata
Ester Maria Orlandi
Sara Galimberti
Gianni Binotto
Nicola Sgherza
Luigia Luciano
Bruno Martino
Antonella Russo Rossi
Massimiliano Bonifacio
Claudio Fozza
Malgorzata Monika Trawinska
Daniele Cattaneo
Chiara Elena
Claudia Baratè
Fiorenza De Gregorio
Matteo Molica
Giorgio La Nasa
Robin Foà
Massimo Breccia
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Keywords: Chronic Myeloid Leukemia
Tyrosine Kinase Inhibitors
Acetylsalicylic Acid
Acetylsalicylic Acid
Tyrosine Kinase Inhibitors
Bosutinib
Dasatinib
Imatinib
Published in: Annals of Hematology / Issue 8/2019
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-019-03705-y

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