Skip to main content
Top
Published in: World Journal of Surgery 5/2019

Open Access 01-05-2019 | Esophageal Cancer | Original Scientific Report

Validity of Surgical Resection for Lymph Node or Pulmonary Recurrence of Esophageal Cancer After Definitive Treatment

Authors: Ayako Shimada, Takahiro Tsushima, Yasuhiro Tsubosa, Eisuke Booka, Katsushi Takebayashi, Masahiro Niihara, Mitsuhiro Isaka, Yasuhisa Ohde, Nozomu Machida, Yusuke Onozawa, Hirofumi Yasui, Hiroya Takeuchi, Yuko Kitagawa

Published in: World Journal of Surgery | Issue 5/2019

Login to get access

Abstract

Background

Despite the poor prognosis of recurrent esophageal squamous cell cancer (ESCC), long-term survival could be achieved in a subset of patients who successfully underwent surgical resection for recurrence. In this study, we investigated the outcomes of surgical resection for lymph node (LN) or pulmonary (PUL) recurrence in ESCC patients.

Methods

We retrospectively analyzed the outcomes of ESCC patients who underwent surgical resection between January 2008 and March 2015 for either LN or PUL recurrence after complete response (CR) by chemoradiotherapy or R0 esophagectomy. Every patient fulfilled the original institutional criteria: no recurrence at primary site; recurrence involving in only one organ; expectation of complete resection; and for PUL recurrence, no rapid growth with at least 2 months of observation.

Results

Among the 13 patients analyzed, surgical resection was performed in nine and four patients with LN and PUL recurrence, respectively. R0 resection was achieved in all patients with no fatal surgical complications. Mean duration from the day of the first CR/R0 to the recurrence was 809 (110–2575) days. Median recurrence-free survival following surgical resection for recurrence and overall survival following the first diagnosis of recurrence was 387 and 1297 days, respectively.

Conclusion

Surgical resection for LN or PUL recurrence of ESCC according to our institutional criteria can be performed safely for selected patients.
Literature
1.
go back to reference Torre LA, Bray F, Siegel RL et al (2015) Global cancer statistics 2012. CA Cancer J Clin 65(2):87–108CrossRef Torre LA, Bray F, Siegel RL et al (2015) Global cancer statistics 2012. CA Cancer J Clin 65(2):87–108CrossRef
2.
go back to reference Ando N, Kato H, Igaki H et al (2012) A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol 19:68–74CrossRefPubMed Ando N, Kato H, Igaki H et al (2012) A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol 19:68–74CrossRefPubMed
3.
go back to reference Sjoquist KM, Burmeister BH, Smithers BM et al (2011) Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncol 12:681–692CrossRefPubMed Sjoquist KM, Burmeister BH, Smithers BM et al (2011) Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. Lancet Oncol 12:681–692CrossRefPubMed
4.
go back to reference Bedenne L, Michel P, Bouche O et al (2007) Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol 25:1160–1168CrossRefPubMed Bedenne L, Michel P, Bouche O et al (2007) Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol 25:1160–1168CrossRefPubMed
5.
go back to reference Nieman DR, Peters JH (2013) Treatment strategies for esophageal cancer. Gastroenterol Clin N Am 42(3):187–197CrossRef Nieman DR, Peters JH (2013) Treatment strategies for esophageal cancer. Gastroenterol Clin N Am 42(3):187–197CrossRef
6.
go back to reference Toh Y (2010) Follow-up and recurrence after a curative esophagectomy for patients with esophageal cancer: the first indicators for recurrence and their prognostic values. Esophagus 7(1):37–43CrossRef Toh Y (2010) Follow-up and recurrence after a curative esophagectomy for patients with esophageal cancer: the first indicators for recurrence and their prognostic values. Esophagus 7(1):37–43CrossRef
7.
go back to reference Ishihara R, Yamamoto S, Iishi H et al (2010) Factors predictive of tumor recurrence and survival after initial complete response of esophageal squamous cell carcinoma to definitive chemoradiotherapy. Int J Radiat Oncol Biol Phys 76(1):123–129CrossRefPubMed Ishihara R, Yamamoto S, Iishi H et al (2010) Factors predictive of tumor recurrence and survival after initial complete response of esophageal squamous cell carcinoma to definitive chemoradiotherapy. Int J Radiat Oncol Biol Phys 76(1):123–129CrossRefPubMed
8.
go back to reference Su XD, Zhang DK, Zhang X et al (2014) Prognostic factors in patients with recurrence after complete resection of esophageal squamous cell carcinoma. J Thorac Dis 6(7):949–957PubMedPubMedCentral Su XD, Zhang DK, Zhang X et al (2014) Prognostic factors in patients with recurrence after complete resection of esophageal squamous cell carcinoma. J Thorac Dis 6(7):949–957PubMedPubMedCentral
9.
go back to reference Mariette C, Balon JM, Piessen G et al (2003) Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease. Cancer 97:1616–1623CrossRefPubMed Mariette C, Balon JM, Piessen G et al (2003) Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease. Cancer 97:1616–1623CrossRefPubMed
10.
go back to reference The Japan Esophageal Society (2017) Guidelines for diagnosis and treatment of carcinoma of the esophagus 2017 edition. Kanehara-shuppan The Japan Esophageal Society (2017) Guidelines for diagnosis and treatment of carcinoma of the esophagus 2017 edition. Kanehara-shuppan
11.
go back to reference Nakamura T, Ota M, Narumiya K et al (2008) Multimodal treatment for lymph node recurrence of esophageal carcinoma after curative resection. Ann Surg Oncol 15(9):2451–2457CrossRefPubMed Nakamura T, Ota M, Narumiya K et al (2008) Multimodal treatment for lymph node recurrence of esophageal carcinoma after curative resection. Ann Surg Oncol 15(9):2451–2457CrossRefPubMed
12.
go back to reference Yano M, Takachi Y, Doki Y et al (2006) Prognosis of patients who develop cervical lymph node recurrence following curative resection for thoracic esophageal cancer. Dis Esophagus 19:73–77CrossRefPubMed Yano M, Takachi Y, Doki Y et al (2006) Prognosis of patients who develop cervical lymph node recurrence following curative resection for thoracic esophageal cancer. Dis Esophagus 19:73–77CrossRefPubMed
14.
go back to reference Kozu Y, Sato H, Tsubosa Y et al (2011) Surgical treatment for pulmonary metastases from esophageal carcinoma after definitive chemoradiotherapy: experience from a single institution. J Cardiothorac Surg 6:135CrossRefPubMedPubMedCentral Kozu Y, Sato H, Tsubosa Y et al (2011) Surgical treatment for pulmonary metastases from esophageal carcinoma after definitive chemoradiotherapy: experience from a single institution. J Cardiothorac Surg 6:135CrossRefPubMedPubMedCentral
15.
go back to reference Ichikawa H, Kosugi S, Nakagawa S et al (2011) Operative treatment for metachronous pulmonary metastasis from esophageal carcinoma. Surgery 149:164–170CrossRefPubMed Ichikawa H, Kosugi S, Nakagawa S et al (2011) Operative treatment for metachronous pulmonary metastasis from esophageal carcinoma. Surgery 149:164–170CrossRefPubMed
16.
go back to reference Chen F, Sato K, Sakai H et al (2008) Pulmonary resection for metastasis from esophageal carcinoma. Interact Cardiovasc Thorac Surg 7:809–812CrossRefPubMed Chen F, Sato K, Sakai H et al (2008) Pulmonary resection for metastasis from esophageal carcinoma. Interact Cardiovasc Thorac Surg 7:809–812CrossRefPubMed
17.
go back to reference Japanese Esophageal Society (2017) Japanese classification of esophageal cancer, 11 edition: part II and III. Esophagus 14:37–65CrossRef Japanese Esophageal Society (2017) Japanese classification of esophageal cancer, 11 edition: part II and III. Esophagus 14:37–65CrossRef
18.
go back to reference Thomford NR, Woolner LB, Clagett OT (1965) The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg 49:357–363PubMed Thomford NR, Woolner LB, Clagett OT (1965) The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg 49:357–363PubMed
20.
go back to reference Yuan X, Lv J, Dong H et al (2017) Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamous cell carcinoma benefit from salvage treatment? Interact Cardiovasc Thorac Surg 24:792–795CrossRefPubMed Yuan X, Lv J, Dong H et al (2017) Does cervical lymph node recurrence after oesophagectomy or definitive chemoradiotherapy for thoracic oesophageal squamous cell carcinoma benefit from salvage treatment? Interact Cardiovasc Thorac Surg 24:792–795CrossRefPubMed
21.
go back to reference Nakagawa S, Kanda T, Kosugi S et al (2004) Recurrence patterns of squamous cell carcinoma of the thoracic esophagus after extended radical esophagectomy with three-field lymphadenectomy. J Am Coll Surg 198:205–211CrossRef Nakagawa S, Kanda T, Kosugi S et al (2004) Recurrence patterns of squamous cell carcinoma of the thoracic esophagus after extended radical esophagectomy with three-field lymphadenectomy. J Am Coll Surg 198:205–211CrossRef
Metadata
Title
Validity of Surgical Resection for Lymph Node or Pulmonary Recurrence of Esophageal Cancer After Definitive Treatment
Authors
Ayako Shimada
Takahiro Tsushima
Yasuhiro Tsubosa
Eisuke Booka
Katsushi Takebayashi
Masahiro Niihara
Mitsuhiro Isaka
Yasuhisa Ohde
Nozomu Machida
Yusuke Onozawa
Hirofumi Yasui
Hiroya Takeuchi
Yuko Kitagawa
Publication date
01-05-2019
Publisher
Springer International Publishing
Published in
World Journal of Surgery / Issue 5/2019
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-018-04904-w

Other articles of this Issue 5/2019

World Journal of Surgery 5/2019 Go to the issue