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World Journal of Surgery

Published in:

01-10-2010

Clinical Outcomes of Patients with Papillary Thyroid Carcinoma after the Detection of Distant Recurrence

Authors: Yasuhiro Ito, Takuya Higashiyama, Yuuki Takamura, Kaoru Kobayashi, Akihiro Miya, Akira Miyauchi

Published in: World Journal of Surgery | Issue 10/2010

Abstract

Purpose

Papillary thyroid carcinoma generally has an excellent prognosis but can have recurrence to the distant organs that is often life-threatening. To date, prognosis and prognostic factors of papillary carcinoma have been intensively investigated, but our knowledge regarding prognosis after the detection of distant recurrence remains inadequate.

Methods

We investigated the prognosis and prognostic factors of papillary carcinoma after distant recurrence was detected during follow-up in a series of 105 patients who underwent locally curative surgery between 1987 and 2004.

Results

To date, 30 patients (29%) have died of carcinoma, and the 5-year and 10-year cause-specific survival (CSS) rates after the detection of distant recurrence were 71 and 50%, respectively. Patients aged 55 years or older at recurrence or with massive extrathyroid extension of primary lesions demonstrated a significantly worse CSS. On multivariate analysis, these two parameters were recognized as independent prognostic factors. Gender, tumor size, and lymph node metastasis did not affect patient prognosis. Uptake of radioactive iodine (RAI) to distant metastasis was not significantly linked to CSS, but none of the patients younger than aged 55 years showing RAI uptake died of carcinoma. Appearance of distant recurrence to organs other than lung also predicted a dire prognosis.

Conclusions

Age at recurrence and extrathyroid extension of primary lesions were significantly related to patient prognosis after the detection of distant recurrence. RAI therapy is effective, especially for younger patients, if metastatic lesions show RAI uptake.

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Title: Clinical Outcomes of Patients with Papillary Thyroid Carcinoma after the Detection of Distant Recurrence
Authors: Yasuhiro Ito
Takuya Higashiyama
Yuuki Takamura
Kaoru Kobayashi
Akihiro Miya
Akira Miyauchi
Publication date: 01-10-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 10/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-010-0712-0

At a glance: The STEP trials

Springer Medicine

Clinical Outcomes of Patients with Papillary Thyroid Carcinoma after the Detection of Distant Recurrence

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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