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Published in: International Orthopaedics 6/2010

01-08-2010 | Review

Cytotherapy of osteonecrosis of the femoral head: a mini review

Authors: You-Shui Gao, Chang-Qing Zhang

Published in: International Orthopaedics | Issue 6/2010

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Abstract

The pathogenesis and aetiology of nontraumatic osteonecrosis of the femoral head has not been revealed completely. However, with advances in stem cell research and regenerative medicine, it is believed that the onset of osteonecrosis of the femoral head probably has a cellular origin, and the possible therapy of osteonecrosis of the femoral head based on cytotherapy has great potential. In this review, the aetiology of osteonecrosis of the femoral head, animal experiments and clinical applications of cytotherapy are summarized and analysed. Current problems and future challenges are discussed.
Literature
1.
go back to reference Liberman JR, Berry DJ, Mont MA, Aaron AK, Callaghan JJ, Rayadhyaksha A, Urbaniak JR (2002) Osteonecrosis of the hip: management in the twenty-first century. J Bone Joint Surg Am 84:834–853 Liberman JR, Berry DJ, Mont MA, Aaron AK, Callaghan JJ, Rayadhyaksha A, Urbaniak JR (2002) Osteonecrosis of the hip: management in the twenty-first century. J Bone Joint Surg Am 84:834–853
2.
go back to reference Liu YF, Chen WM, Lin YF, Yang RC, Lin MW, Li LH et al (2005) Type II collagen gene variants and inherited osteonecrosis of the femoral head. N Eng J Med 352:2294–2301CrossRef Liu YF, Chen WM, Lin YF, Yang RC, Lin MW, Li LH et al (2005) Type II collagen gene variants and inherited osteonecrosis of the femoral head. N Eng J Med 352:2294–2301CrossRef
3.
go back to reference Chang JK, Ho ML, Yeh CH, Chen CH, Wang GJ (2006) Osteogenic gene expression decreases in stromal cells of patients with osteonecrosis. Clin Orthop Relat Res 453:286–292CrossRefPubMed Chang JK, Ho ML, Yeh CH, Chen CH, Wang GJ (2006) Osteogenic gene expression decreases in stromal cells of patients with osteonecrosis. Clin Orthop Relat Res 453:286–292CrossRefPubMed
4.
go back to reference Jones LC, Hungerford DS (2007) The pathogenesis of osteonecrosis. Instr Course Lect 56:179–196PubMed Jones LC, Hungerford DS (2007) The pathogenesis of osteonecrosis. Instr Course Lect 56:179–196PubMed
5.
go back to reference Johannson HR, Zywiel MG, Marker DR, Jones LC, McGrath MS, Mont MA (2010) Osteonecrosis is not a predictor of poor outcomes in primary total hip arthroplasty: a systemic literature review. Int Orthop doi:10.1007/s00264-010-0979-7 Johannson HR, Zywiel MG, Marker DR, Jones LC, McGrath MS, Mont MA (2010) Osteonecrosis is not a predictor of poor outcomes in primary total hip arthroplasty: a systemic literature review. Int Orthop doi:10.​1007/​s00264-010-0979-7
6.
go back to reference Vilquin JT, Rosset P (2006) Mesenchymal stem cells in bone and cartilage repair: current status. Regenerative Med 1:589–604CrossRef Vilquin JT, Rosset P (2006) Mesenchymal stem cells in bone and cartilage repair: current status. Regenerative Med 1:589–604CrossRef
7.
go back to reference Aldridge JM III, Urbaniak JR (2007) Avascular necrosis of the femoral head: role of vascularized bone grafts. Orthop Clin N Am 38:13–22CrossRef Aldridge JM III, Urbaniak JR (2007) Avascular necrosis of the femoral head: role of vascularized bone grafts. Orthop Clin N Am 38:13–22CrossRef
8.
go back to reference Aldridge JM III, Urbaniak JR (2008) Free vascularized bone grafting for the treatment of osteonecrosis of the femoral head. Tech Orthop 23:44–53CrossRef Aldridge JM III, Urbaniak JR (2008) Free vascularized bone grafting for the treatment of osteonecrosis of the femoral head. Tech Orthop 23:44–53CrossRef
9.
go back to reference Feng Y, Wang S, Jin D, Sheng J, Chen S, Cheng X, Zhang C (2009) Free vascularised fibular grafting with Osteoset®2 demineralised bone matrix versus autograft for large osteonecrotic lesions of the femoral head. Int Orthop doi:10.1007/s00264-009-0915-x Feng Y, Wang S, Jin D, Sheng J, Chen S, Cheng X, Zhang C (2009) Free vascularised fibular grafting with Osteoset®2 demineralised bone matrix versus autograft for large osteonecrotic lesions of the femoral head. Int Orthop doi:10.​1007/​s00264-009-0915-x
10.
go back to reference Abdallah BM, Saeed H, Kassem M (2009) Human mesenchymal stem cells: basic biology and clinical applications for bone tissue regeneration. In: Baharvand H (ed) Trends in stem cell biology and technology. Humana Press, NJ, pp 177–190CrossRef Abdallah BM, Saeed H, Kassem M (2009) Human mesenchymal stem cells: basic biology and clinical applications for bone tissue regeneration. In: Baharvand H (ed) Trends in stem cell biology and technology. Humana Press, NJ, pp 177–190CrossRef
11.
go back to reference Gangji V, Hauzeur JP (2009) Cellular-based therapy for osteonecrosis. Orthop Clin N Am 40:213–221CrossRef Gangji V, Hauzeur JP (2009) Cellular-based therapy for osteonecrosis. Orthop Clin N Am 40:213–221CrossRef
12.
go back to reference Crovace A, Favia A, Lacitignola L, Di Comite MS, Staffieri F, Francioso E (2008) Use of autologous bone marrow mononuclear cells and cultured bone marrow stromal cells in dogs with orthopaedic lesions. Vet Res Commun 32(Suppl 1):S39–S44CrossRefPubMed Crovace A, Favia A, Lacitignola L, Di Comite MS, Staffieri F, Francioso E (2008) Use of autologous bone marrow mononuclear cells and cultured bone marrow stromal cells in dogs with orthopaedic lesions. Vet Res Commun 32(Suppl 1):S39–S44CrossRefPubMed
13.
go back to reference Sun Y, Feng Y, Zhang C (2009) The effect of bone marrow mononuclear cells on vascularization and bone regeneration in steroid-induced osteonecrosis of the femoral head. Joint Bone Spine 76:685–690CrossRefPubMed Sun Y, Feng Y, Zhang C (2009) The effect of bone marrow mononuclear cells on vascularization and bone regeneration in steroid-induced osteonecrosis of the femoral head. Joint Bone Spine 76:685–690CrossRefPubMed
14.
go back to reference Kasten P, Beyen I, Egermann M, Suda AJ, Moghaddam AA, Zimmermann G et al (2008) Instant stem cell therapy: characterization and concentration of human mesenchymal stem cells in vitro. Eur Cells Materials 16:47–55 Kasten P, Beyen I, Egermann M, Suda AJ, Moghaddam AA, Zimmermann G et al (2008) Instant stem cell therapy: characterization and concentration of human mesenchymal stem cells in vitro. Eur Cells Materials 16:47–55
15.
go back to reference Lee K, Chan CK, Patil N, Goodman SB (2009) Cell therapy for bone regeneration—bench to bedside. J Biomed Mater Res B Appl Biomater 89:252–263PubMed Lee K, Chan CK, Patil N, Goodman SB (2009) Cell therapy for bone regeneration—bench to bedside. J Biomed Mater Res B Appl Biomater 89:252–263PubMed
16.
go back to reference Gangji V, Hauzeur JP, Schoutens A, Hinsenkamp M, Appelboom T, Egrise D (2003) Abnormalities in the replicative capacity of osteoblastic cells in the proximal femur of patients with osteonecrosis of the femoral head. J Rheumatol 30:348–351PubMed Gangji V, Hauzeur JP, Schoutens A, Hinsenkamp M, Appelboom T, Egrise D (2003) Abnormalities in the replicative capacity of osteoblastic cells in the proximal femur of patients with osteonecrosis of the femoral head. J Rheumatol 30:348–351PubMed
17.
go back to reference Lee HS, Huang GT, Chiang H, Chiou LL, Chen MH, Hsieh SH, Jiang CC (2003) Multipotential mesenchymal stem cells from femoral bone marrow near the site of osteonecrosis. Stem Cells 21:190–199CrossRefPubMed Lee HS, Huang GT, Chiang H, Chiou LL, Chen MH, Hsieh SH, Jiang CC (2003) Multipotential mesenchymal stem cells from femoral bone marrow near the site of osteonecrosis. Stem Cells 21:190–199CrossRefPubMed
18.
go back to reference Hernigou P, Beaujean F, Lambotte JC (1999) Decrease in the mesenchymal stem-cell pool in proximal femur in corticosteroid-induced osteonecrosis. J Bone Joint Surg Br 81:349–355CrossRefPubMed Hernigou P, Beaujean F, Lambotte JC (1999) Decrease in the mesenchymal stem-cell pool in proximal femur in corticosteroid-induced osteonecrosis. J Bone Joint Surg Br 81:349–355CrossRefPubMed
19.
go back to reference Lee JS, Lee JS, Roh HL, Kim CH, Jung JS, Suh KT (2006) Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor. J Orthop Res 24:604–609CrossRefPubMed Lee JS, Lee JS, Roh HL, Kim CH, Jung JS, Suh KT (2006) Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor. J Orthop Res 24:604–609CrossRefPubMed
20.
go back to reference Suh KT, Kim SW, Roh HL, Youn MS, Jung JS (2005) Decreased osteogenic differentiation of mesenchymal stem cells in alcohol-induced osteonecrosis. Clin Orthop Relat Res 431:220–225CrossRefPubMed Suh KT, Kim SW, Roh HL, Youn MS, Jung JS (2005) Decreased osteogenic differentiation of mesenchymal stem cells in alcohol-induced osteonecrosis. Clin Orthop Relat Res 431:220–225CrossRefPubMed
21.
go back to reference Feng Y, Yang SH, Xiao BJ, Xu WH, Ye SN, Xia T et al (2010) Decreased in the number and function of circulation endothelial progenitor cells in patients with avascular necrosis of the femoral head. Bone 46:32–40CrossRefPubMed Feng Y, Yang SH, Xiao BJ, Xu WH, Ye SN, Xia T et al (2010) Decreased in the number and function of circulation endothelial progenitor cells in patients with avascular necrosis of the femoral head. Bone 46:32–40CrossRefPubMed
22.
go back to reference Grellier M, Bordenave L, Amédée J (2009) Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering. Trends Biotechnol 27:562–571CrossRefPubMed Grellier M, Bordenave L, Amédée J (2009) Cell-to-cell communication between osteogenic and endothelial lineages: implications for tissue engineering. Trends Biotechnol 27:562–571CrossRefPubMed
23.
go back to reference Wang Y, Wan C, Gilbert SR, Clemens TL (2007) Oxygen sensing and osteogenesis. Ann N Y Acad Sci 1117:1–11CrossRefPubMed Wang Y, Wan C, Gilbert SR, Clemens TL (2007) Oxygen sensing and osteogenesis. Ann N Y Acad Sci 1117:1–11CrossRefPubMed
24.
go back to reference Xue Y, Xing Z, Hellem S, Arvidson K, Mustafa K (2009) Endothelial cells influence the osteogenic potential of bone marrow stromal cells. Biomed Eng Online 8:34CrossRefPubMed Xue Y, Xing Z, Hellem S, Arvidson K, Mustafa K (2009) Endothelial cells influence the osteogenic potential of bone marrow stromal cells. Biomed Eng Online 8:34CrossRefPubMed
25.
go back to reference Samee M, Kasugai S, Kondo H, Ohya K, Shimokawa H, Kuroda S (2008) Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) transfection to human periosteal cells enhances osteoblast differentiation and bone formation. J Pharmacol Sci 108:18–31CrossRefPubMed Samee M, Kasugai S, Kondo H, Ohya K, Shimokawa H, Kuroda S (2008) Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) transfection to human periosteal cells enhances osteoblast differentiation and bone formation. J Pharmacol Sci 108:18–31CrossRefPubMed
26.
go back to reference Asada T, Kushida T, Umeda M, Oe K, Matsuya H, Wada T et al (2008) Prevention of corticosteroid-induced osteonecrosis in rabbits by intra-bone marrow injection of autologous bone marrow cells. Rheumatology (Oxford) 47:591–596CrossRef Asada T, Kushida T, Umeda M, Oe K, Matsuya H, Wada T et al (2008) Prevention of corticosteroid-induced osteonecrosis in rabbits by intra-bone marrow injection of autologous bone marrow cells. Rheumatology (Oxford) 47:591–596CrossRef
27.
go back to reference Yan Z, Hang D, Guo C, Chen Z (2009) Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. J Orthop Res 27:442–446CrossRefPubMed Yan Z, Hang D, Guo C, Chen Z (2009) Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. J Orthop Res 27:442–446CrossRefPubMed
28.
go back to reference Hernigou P, Beaujean F (2002) Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res 405:14–23CrossRefPubMed Hernigou P, Beaujean F (2002) Treatment of osteonecrosis with autologous bone marrow grafting. Clin Orthop Relat Res 405:14–23CrossRefPubMed
29.
go back to reference Hernigou P, Poignard A, Zilber S, Rouard H (2008) Cell therapy of hip osteonecrosis with autologous bone marrow grafting. Indian J Orthop 43:40–45CrossRef Hernigou P, Poignard A, Zilber S, Rouard H (2008) Cell therapy of hip osteonecrosis with autologous bone marrow grafting. Indian J Orthop 43:40–45CrossRef
30.
go back to reference Hernigou P, Zilber S, Filippini P, Rouard H, Methieu G, Poignard A (2008) Bone marrow injection in hip osteonecrosis. Tech Orthop 23:18–25CrossRef Hernigou P, Zilber S, Filippini P, Rouard H, Methieu G, Poignard A (2008) Bone marrow injection in hip osteonecrosis. Tech Orthop 23:18–25CrossRef
31.
go back to reference Gangji V, Bastianelli E, Toungouz M, Hauzeur J (2007) Treatment of osteonecrosis of the femoral head with implantation of preosteoblastic cells into the necrotic zone: case report. Bone 40:S47, AbstractCrossRef Gangji V, Bastianelli E, Toungouz M, Hauzeur J (2007) Treatment of osteonecrosis of the femoral head with implantation of preosteoblastic cells into the necrotic zone: case report. Bone 40:S47, AbstractCrossRef
32.
go back to reference Wang BL, Sun W, Shi ZC, Zhang NF, Yue DB, Guo WS et al (2009) Treatment of nontraumatic osteonecrosis of the femoral head with the implantation of core decompression and concentrated autologous bone marrow containing mononuclear cells. Arch Orthop Trauma Surg doi:10.1007/s00402-009-0939-0 Wang BL, Sun W, Shi ZC, Zhang NF, Yue DB, Guo WS et al (2009) Treatment of nontraumatic osteonecrosis of the femoral head with the implantation of core decompression and concentrated autologous bone marrow containing mononuclear cells. Arch Orthop Trauma Surg doi:10.​1007/​s00402-009-0939-0
33.
go back to reference Kang JS, Moon KH, Park SR, Kang SB, Park HB, Lee SH (2008) [Clinical results of autoiliac cancellous bone graft combined with implantation of autologous bone marrow cells for osteonecrosis of the femoral head]. J Korean Orthop Assoc 43:1–8 (in Korean)CrossRef Kang JS, Moon KH, Park SR, Kang SB, Park HB, Lee SH (2008) [Clinical results of autoiliac cancellous bone graft combined with implantation of autologous bone marrow cells for osteonecrosis of the femoral head]. J Korean Orthop Assoc 43:1–8 (in Korean)CrossRef
34.
go back to reference Mont MA, Jones LC, Einhorn TA, Hungerford DS, Reddi H (1998) Osteonecrosis of the femoral head: potential treatment with growth and differentiation factors. Clin Orthop Relat Res 355S:S314–S335CrossRef Mont MA, Jones LC, Einhorn TA, Hungerford DS, Reddi H (1998) Osteonecrosis of the femoral head: potential treatment with growth and differentiation factors. Clin Orthop Relat Res 355S:S314–S335CrossRef
35.
go back to reference Liberman JR, Conduah A, Urist MR (2004) Treatment of osteonecrosis of the femoral head with core decompression and human bone morphogenetic protein. Clin Orthop Relat Res 429:139–145CrossRef Liberman JR, Conduah A, Urist MR (2004) Treatment of osteonecrosis of the femoral head with core decompression and human bone morphogenetic protein. Clin Orthop Relat Res 429:139–145CrossRef
36.
go back to reference Suzuki O, Bishop A, Sunagawa T, Katsube K, Friedrich PF (2004) VEGF-promoted surgical angiogenesis in necrotic bone. Microsurgery 24:85–91CrossRefPubMed Suzuki O, Bishop A, Sunagawa T, Katsube K, Friedrich PF (2004) VEGF-promoted surgical angiogenesis in necrotic bone. Microsurgery 24:85–91CrossRefPubMed
37.
go back to reference Xiao ZM, Jiang H, Zhan XL, Wu ZG, Zhang XL (2008) Treatment of osteonecrosis of femoral head with BMSCs-seeded bio-derived bone materials combined with rhBMP-2 in rabbits. Chin J Traumatol 11:165–170CrossRefPubMed Xiao ZM, Jiang H, Zhan XL, Wu ZG, Zhang XL (2008) Treatment of osteonecrosis of femoral head with BMSCs-seeded bio-derived bone materials combined with rhBMP-2 in rabbits. Chin J Traumatol 11:165–170CrossRefPubMed
38.
go back to reference Bajada S, Mazakova I, Richardson JB, Ashammakhi N (2008) Update on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med 2:169–183CrossRefPubMed Bajada S, Mazakova I, Richardson JB, Ashammakhi N (2008) Update on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med 2:169–183CrossRefPubMed
39.
go back to reference Derubeis AR, Cancedda R (2004) Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng 32:160–165CrossRefPubMed Derubeis AR, Cancedda R (2004) Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng 32:160–165CrossRefPubMed
40.
go back to reference Kerachian MA, Séguin C, Harvey EJ (2009) Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action. J Steroid Biochem Mol Biol 114:121–128CrossRefPubMed Kerachian MA, Séguin C, Harvey EJ (2009) Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action. J Steroid Biochem Mol Biol 114:121–128CrossRefPubMed
41.
go back to reference Li Y, Han R, Geng C, Wang Y, Wei L (2009) A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone. Int Orthop 33:573–580CrossRefPubMed Li Y, Han R, Geng C, Wang Y, Wei L (2009) A new osteonecrosis animal model of the femoral head induced by microwave heating and repaired with tissue engineered bone. Int Orthop 33:573–580CrossRefPubMed
42.
go back to reference Jackson SM, Major NM (2004) Pathologic conditions mimicking osteonecrosis. Orthop Clin N Am 35:315–320CrossRef Jackson SM, Major NM (2004) Pathologic conditions mimicking osteonecrosis. Orthop Clin N Am 35:315–320CrossRef
Metadata
Title
Cytotherapy of osteonecrosis of the femoral head: a mini review
Authors
You-Shui Gao
Chang-Qing Zhang
Publication date
01-08-2010
Publisher
Springer-Verlag
Published in
International Orthopaedics / Issue 6/2010
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-010-1009-5

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