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01-06-2021 | Ultrasound | Review

Current update on gallbladder carcinoma

Authors: Dhakshinamoorthy Ganeshan, Avinash Kambadakone, Paul Nikolaidis, Vivek Subbiah, Ishwaria M. Subbiah, Catherine Devine

Published in: Abdominal Radiology | Issue 6/2021

Abstract

Gallbladder (GB) carcinoma is a relatively rare malignancy and is associated with poor prognosis. Numerous risk factors have been associated with the development of GB carcinoma. GB carcinomas may present as mass lesions replacing the GB, focal or diffuse thickening of the GB wall, and intraluminal mass in the GB. Various benign conditions can mimic GB carcinoma. This article reviews the epidemiology, pathology, clinical findings, imaging features, and management of GB carcinomas.

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Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68 (6):394-424. https://doi.org/10.3322/caac.21492

Gallbladder cancer statistics. https://www.wcrf.org/dietandcancer/cancer-trends/gallbladder-cancer-statistics.

Carriaga MT, Henson DE (1995) Liver, gallbladder, extrahepatic bile ducts, and pancreas. Cancer 75 (1 Suppl):171–190. https://doi.org/10.1002/1097-0142(19950101)75:1+<171::aid-cncr2820751306>3.0.co;2-2

Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70 (1):7-30. https://doi.org/10.3322/caac.21590

Henson DE, Albores-Saavedra J, Corle D (1992) Carcinoma of the gallbladder. Histologic types, stage of disease, grade, and survival rates. Cancer 70 (6):1493–1497. https://doi.org/10.1002/1097-0142(19920915)70:6<1493::aid-cncr2820700608>3.0.co;2-u

Duffy A, Capanu M, Abou-Alfa GK, Huitzil D, Jarnagin W, Fong Y, D'Angelica M, Dematteo RP, Blumgart LH, O'Reilly EM (2008) Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC). J Surg Oncol 98 (7):485–489. https://doi.org/10.1002/jso.21141

Stinton LM, Shaffer EA (2012) Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver 6 (2):172–187. https://doi.org/10.5009/gnl.2012.6.2.172

Hemminki K, Li X (2003) Familial liver and gall bladder cancer: a nationwide epidemiological study from Sweden. Gut 52 (4):592–596. https://doi.org/10.1136/gut.52.4.592

Muszynska C, Lundgren L, Lindell G, Andersson R, Nilsson J, Sandstrom P, Andersson B (2017) Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease: Results from a population-based gallstone surgery registry. Surgery 162 (2):256–263. https://doi.org/10.1016/j.surg.2017.02.009

10.

Lowenfels AB, Walker AM, Althaus DP, Townsend G, Domellof L (1989) Gallstone growth, size, and risk of gallbladder cancer: an interracial study. Int J Epidemiol 18 (1):50–54. https://doi.org/10.1093/ije/18.1.50

11.

Zatonski WA, Lowenfels AB, Boyle P, Maisonneuve P, Bueno de Mesquita HB, Ghadirian P, Jain M, Przewozniak K, Baghurst P, Moerman CJ, Simard A, Howe GR, McMichael AJ, Hsieh CC, Walker AM (1997) Epidemiologic aspects of gallbladder cancer: a case-control study of the SEARCH Program of the International Agency for Research on Cancer. J Natl Cancer Inst 89 (15):1132–1138. https://doi.org/10.1093/jnci/89.15.1132

12.

Schnelldorfer T (2013) Porcelain gallbladder: a benign process or concern for malignancy? J Gastrointest Surg 17 (6):1161–1168. https://doi.org/10.1007/s11605-013-2170-0

13.

Khan ZS, Livingston EH, Huerta S (2011) Reassessing the need for prophylactic surgery in patients with porcelain gallbladder: case series and systematic review of the literature. Arch Surg 146 (10):1143–1147. https://doi.org/10.1001/archsurg.2011.257

14.

Elmasry M, Lindop D, Dunne DF, Malik H, Poston GJ, Fenwick SW (2016) The risk of malignancy in ultrasound detected gallbladder polyps: A systematic review. Int J Surg 33 Pt A:28–35. https://doi.org/10.1016/j.ijsu.2016.07.061

15.

Jorgensen T, Jensen KH (1990) Polyps in the gallbladder. A prevalence study. Scand J Gastroenterol 25 (3):281–286

16.

Farinon AM, Pacella A, Cetta F, Sianesi M (1991) "Adenomatous polyps of the gallbladder" adenomas of the gallbladder. HPB Surg 3 (4):251–258. https://doi.org/10.1155/1991/59324

17.

Ishikawa O, Ohhigashi H, Imaoka S, Nakaizumi A, Kitamura T, Sasaki Y, Shibata T, Wada A, Iwanaga T (1989) The difference in malignancy between pedunculated and sessile polypoid lesions of the gallbladder. Am J Gastroenterol 84 (11):1386–1390

18.

Koga A, Watanabe K, Fukuyama T, Takiguchi S, Nakayama F (1988) Diagnosis and operative indications for polypoid lesions of the gallbladder. Arch Surg 123 (1):26–29. https://doi.org/10.1001/archsurg.1988.01400250028003

19.

Tsuchiya K UM (1986) [Collective review of 503 cases of small polypoid lesions (less than 20mm in maximum diameter) of the gallbladder: size distribution in various diseases and the depth of carcinomatous invasion]. Nihon Shokakibyo Gakkai Zasshi 83 (9):2086–2087

20.

Wang YF, Feng FL, Zhao XH, Ye ZX, Zeng HP, Li Z, Jiang XQ, Peng ZH (2014) Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer. World J Gastroenterol 20 (14):4085–4092. https://doi.org/10.3748/wjg.v20.i14.4085

21.

Morine Y, Shimada M, Takamatsu H, Araida T, Endo I, Kubota M, Toki A, Noda T, Matsumura T, Miyakawa S, Ishibashi H, Kamisawa T, Shimada H (2013) Clinical features of pancreaticobiliary maljunction: update analysis of 2nd Japan-nationwide survey. J Hepatobiliary Pancreat Sci 20 (5):472–480. https://doi.org/10.1007/s00534-013-0606-2

22.

Rawla P, Sunkara T, Thandra KC, Barsouk A (2019) Epidemiology of gallbladder cancer. Clin Exp Hepatol 5 (2):93–102. https://doi.org/10.5114/ceh.2019.85166

23.

Ten Hove A, de Meijer VE, Hulscher JBF, de Kleine RHJ (2018) Meta-analysis of risk of developing malignancy in congenital choledochal malformation. Br J Surg 105 (5):482–490. https://doi.org/10.1002/bjs.10798

24.

van Erp LW, Cunningham M, Narasimman M, Ale Ali H, Jhaveri K, Drenth JPH, Janssen HLA, Levy C, Hirschfield GM, Hansen BE, Gulamhusein AF (2020) Risk of gallbladder cancer in patients with primary sclerosing cholangitis and radiographically detected gallbladder polyps. Liver Int 40 (2):382–392. https://doi.org/10.1111/liv.14326

25.

Samuel S, Mukherjee S, Ammannagari N, Pokuri VK, Kuvshinoff B, Groman A, LeVea CM, Iyer R (2018) Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: A population-based study. PLoS One 13 (6):e0198809. https://doi.org/10.1371/journal.pone.0198809

26.

Yang Z, Yang Z, Zou Q, Yuan Y, Li J, Li D, Liang L, Zeng G, Chen S (2014) A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder. Int J Clin Oncol 19 (2):325–335. https://doi.org/10.1007/s10147-013-0550-9

27.

Albores-Saavedra J HDTotgaebdaotpF, ser 2. Washington, DC: Armed Forces Institute of Pathology, 1986.

28.

Pradeep R, Kaushik SP, Sikora SS, Bhattacharya BN, Pandey CM, Kapoor VK (1995) Predictors of survival in patients with carcinoma of the gallbladder. Cancer 76 (7):1145–1149. https://doi.org/10.1002/1097-0142(19951001)76:7<1145::aid-cncr2820760708>3.0.co;2-3

29.

Shukla VK, Gurubachan, Sharma D, Dixit VK, Usha (2006) Diagnostic value of serum CA242, CA 19–9, CA 15–3 and CA 125 in patients with carcinoma of the gallbladder. Trop Gastroenterol 27 (4):160–165

30.

Corwin MT, Khera SS, Loehfelm TW, Yang NT, Fananapazir G (2019) Incidentally Detected Focal Fundal Gallbladder Wall Thickening at Contrast-Enhanced Computed Tomography: Prevalence and Computed Tomography Features of Malignancy. J Comput Assist Tomogr 43 (1):149–154. https://doi.org/10.1097/RCT.0000000000000802

31.

Demachi H, Matsui O, Hoshiba K, Kimura M, Miyata S, Kuroda Y, Konishi K, Tsuji M, Miwa A (1997) Dynamic MRI using a surface coil in chronic cholecystitis and gallbladder carcinoma: radiologic and histopathologic correlation. J Comput Assist Tomogr 21 (4):643–651. https://doi.org/10.1097/00004728-199707000-00025

32.

Heller SL, Lee VS (2005) MR imaging of the gallbladder and biliary system. Magn Reson Imaging Clin N Am 13 (2):295–311. https://doi.org/10.1016/j.mric.2005.03.003

33.

Hwang J, Kim YK, Choi D, Rhim H, Lee WJ, Hong SS, Kim HJ, Chang YW (2014) Gadoxetic acid-enhanced MRI for T-staging of gallbladder carcinoma: emphasis on liver invasion. Br J Radiol 87 (1033):20130608. https://doi.org/10.1259/bjr.20130608

34.

Kalra N, Suri S, Gupta R, Natarajan SK, Khandelwal N, Wig JD, Joshi K (2006) MDCT in the staging of gallbladder carcinoma. AJR Am J Roentgenol 186 (3):758–762. https://doi.org/10.2214/AJR.04.1342

35.

Kim SJ, Lee JM, Kim H, Yoon JH, Han JK, Choi BI (2013) Role of diffusion-weighted magnetic resonance imaging in the diagnosis of gallbladder cancer. J Magn Reson Imaging 38 (1):127–137. https://doi.org/10.1002/jmri.23956

36.

Kim SJ, Lee JM, Lee ES, Han JK, Choi BI (2015) Preoperative staging of gallbladder carcinoma using biliary MR imaging. J Magn Reson Imaging 41 (2):314–321. https://doi.org/10.1002/jmri.24537

37.

Kim SJ, Lee JM, Lee JY, Choi JY, Kim SH, Han JK, Choi BI (2008) Accuracy of preoperative T-staging of gallbladder carcinoma using MDCT. AJR Am J Roentgenol 190 (1):74–80. https://doi.org/10.2214/AJR.07.2348

38.

Kitazume Y, Taura S, Nakaminato S, Noguchi O, Masaki Y, Kasahara I, Kishino M, Tateishi U (2016) Diffusion-weighted magnetic resonance imaging to differentiate malignant from benign gallbladder disorders. Eur J Radiol 85 (4):864–873. https://doi.org/10.1016/j.ejrad.2016.02.003

39.

Schwartz LH, Black J, Fong Y, Jarnagin W, Blumgart L, Gruen D, Winston C, Panicek DM (2002) Gallbladder carcinoma: findings at MR imaging with MR cholangiopancreatography. J Comput Assist Tomogr 26 (3):405–410. https://doi.org/10.1097/00004728-200205000-00015

40.

Sugita R, Yamazaki T, Furuta A, Itoh K, Fujita N, Takahashi S (2009) High b-value diffusion-weighted MRI for detecting gallbladder carcinoma: preliminary study and results. Eur Radiol 19 (7):1794–1798. https://doi.org/10.1007/s00330-009-1322-9

41.

Kim SW, Kim HC, Yang DM, Ryu JK, Won KY (2016) Gallbladder carcinoma: causes of misdiagnosis at CT. Clin Radiol 71 (1):e96–109. https://doi.org/10.1016/j.crad.2015.10.016

42.

Hussain HM, Little MD, Wei S (2013) AIRP best cases in radiologic-pathologic correlation: gallbladder carcinoma with direct invasion of the liver. Radiographics 33 (1):103–108. https://doi.org/10.1148/rg.331115163

43.

Catalano OA, Sahani DV, Kalva SP, Cushing MS, Hahn PF, Brown JJ, Edelman RR (2008) MR imaging of the gallbladder: a pictorial essay. Radiographics 28 (1):135–155; quiz 324. https://doi.org/10.1148/rg.281065183

44.

Levy AD, Murakata LA, Abbott RM, Rohrmann CA, Jr. (2002) From the archives of the AFIP. Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: radiologic-pathologic correlation. Armed Forces Institute of Pathology. Radiographics 22 (2):387–413. https://doi.org/10.1148/radiographics.22.2.g02mr08387

45.

Levy AD, Murakata LA, Rohrmann CA, Jr. (2001) Gallbladder carcinoma: radiologic-pathologic correlation. Radiographics 21 (2):295–314; questionnaire, 549–255. https://doi.org/10.1148/radiographics.21.2.g01mr16295

46.

Franquet T, Montes M, Ruiz de Azua Y, Jimenez FJ, Cozcolluela R (1991) Primary gallbladder carcinoma: imaging findings in 50 patients with pathologic correlation. Gastrointest Radiol 16 (2):143–148. https://doi.org/10.1007/BF01887330

47.

Weiner SN, Koenigsberg M, Morehouse H, Hoffman J (1984) Sonography and computed tomography in the diagnosis of carcinoma of the gallbladder. AJR Am J Roentgenol 142 (4):735–739. https://doi.org/10.2214/ajr.142.4.735

48.

Itai Y, Araki T, Yoshikawa K, Furui S, Yashiro N, Tasaka A (1980) Computed tomography of gallbladder carcinoma. Radiology 137 (3):713–718. https://doi.org/10.1148/radiology.137.3.7444054

49.

Yeh HC (1979) Ultrasonography and computed tomography of carcinoma of the gallbladder. Radiology 133 (1):167–173. https://doi.org/10.1148/133.1.167

50.

Chen LD, Huang Y, Xie XH, Chen W, Shan QY, Xu M, Liu JY, Nie ZQ, Xie XY, Lu MD, Shen SL, Wang W (2017) Diagnostic nomogram for gallbladder wall thickening mimicking malignancy: using contrast-enhanced ultrasonography or multi-detector computed tomography? Abdom Radiol (NY) 42 (10):2436–2446. https://doi.org/10.1007/s00261-017-1162-z

51.

Xie XH, Xu HX, Xie XY, Lu MD, Kuang M, Xu ZF, Liu GJ, Wang Z, Liang JY, Chen LD, Lin MX (2010) Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound. Eur Radiol 20 (1):239–248. https://doi.org/10.1007/s00330-009-1538-8

52.

Xu JM, Guo LH, Xu HX, Zheng SG, Liu LN, Sun LP, Lu MD, Wang WP, Hu B, Yan K, Hong D, Tang SS, Qian LX, Luo BM (2014) Differential diagnosis of gallbladder wall thickening: the usefulness of contrast-enhanced ultrasound. Ultrasound Med Biol 40 (12):2794–2804. https://doi.org/10.1016/j.ultrasmedbio.2014.06.015

53.

Runner GJ, Corwin MT, Siewert B, Eisenberg RL (2014) Gallbladder wall thickening. AJR Am J Roentgenol 202 (1):W1-W12. https://doi.org/10.2214/AJR.12.10386

54.

Kim SJ, Lee JM, Lee JY, Kim SH, Han JK, Choi BI, Choi JY (2008) Analysis of enhancement pattern of flat gallbladder wall thickening on MDCT to differentiate gallbladder cancer from cholecystitis. AJR Am J Roentgenol 191 (3):765–771. https://doi.org/10.2214/AJR.07.3331

55.

Yun EJ, Cho SG, Park S, Park SW, Kim WH, Kim HJ, Suh CH (2004) Gallbladder carcinoma and chronic cholecystitis: differentiation with two-phase spiral CT. Abdom Imaging 29 (1):102–108. https://doi.org/10.1007/s00261-003-0080-4

56.

Tongdee R, Maroongroge P, Suthikeree W (2011) The value of MDCT scans in differentiation between benign and malignant gallbladder wall thickening. J Med Assoc Thai 94 (5):592–600

57.

Kelekis NL, Semelka RC (1996) MR imaging of the gallbladder. Top Magn Reson Imaging 8 (5):312–320. https://doi.org/10.1097/00002142-199610000-00006

58.

Jung SE, Lee JM, Lee K, Rha SE, Choi BG, Kim EK, Hahn ST (2005) Gallbladder wall thickening: MR imaging and pathologic correlation with emphasis on layered pattern. Eur Radiol 15 (4):694–701. https://doi.org/10.1007/s00330-004-2539-2

59.

Lee NK, Kim S, Kim TU, Kim DU, Seo HI, Jeon TY (2014) Diffusion-weighted MRI for differentiation of benign from malignant lesions in the gallbladder. Clin Radiol 69 (2):e78–85. https://doi.org/10.1016/j.crad.2013.09.017

60.

Min JH, Kang TW, Cha DI, Kim SH, Shin KS, Lee JE, Jang KT, Ahn SH (2019) Apparent diffusion coefficient as a potential marker for tumour differentiation, staging and long-term clinical outcomes in gallbladder cancer. Eur Radiol 29 (1):411–421. https://doi.org/10.1007/s00330-018-5602-0

61.

Hirooka Y, Naitoh Y, Goto H, Furukawa T, Ito A, Hayakawa T (1996) Differential diagnosis of gall-bladder masses using colour Doppler ultrasonography. J Gastroenterol Hepatol 11 (9):840–846. https://doi.org/10.1111/j.1440-1746.1996.tb00090.x

62.

Choi JH, Seo DW, Choi JH, Park DH, Lee SS, Lee SK, Kim MH (2013) Utility of contrast-enhanced harmonic EUS in the diagnosis of malignant gallbladder polyps (with videos). Gastrointest Endosc 78 (3):484–493. https://doi.org/10.1016/j.gie.2013.03.1328

63.

Sun LP, Guo LH, Xu HX, Liu LN, Xu JM, Zhang YF, Liu C, Bo XW, Xu XH (2015) Value of contrast-enhanced ultrasound in the differential diagnosis between gallbladder adenoma and gallbladder adenoma canceration. Int J Clin Exp Med 8 (1):1115–1121

64.

Teber MA, Tan S, Donmez U, Ipek A, Ucar AE, Yildirim H, Aslan A, Arslan H (2014) The use of real-time elastography in the assessment of gallbladder polyps: preliminary observations. Med Ultrason 16 (4):304–308. https://doi.org/10.11152/mu.201.3.2066.164.1mat

65.

Kapoor A, Kapoor A, Mahajan G (2011) Differentiating malignant from benign thickening of the gallbladder wall by the use of acoustic radiation force impulse elastography. J Ultrasound Med 30 (11):1499–1507. https://doi.org/10.7863/jum.2011.30.11.1499

66.

Jeong Y, Kim JH, Chae HD, Park SJ, Bae JS, Joo I, Han JK (2020) Deep learning-based decision support system for the diagnosis of neoplastic gallbladder polyps on ultrasonography: Preliminary results. Sci Rep 10 (1):7700. https://doi.org/10.1038/s41598-020-64205-y

67.

Choi TW, Kim JH, Park SJ, Ahn SJ, Joo I, Han JK (2018) Risk stratification of gallbladder polyps larger than 10 mm using high-resolution ultrasonography and texture analysis. Eur Radiol 28 (1):196–205. https://doi.org/10.1007/s00330-017-4954-1

68.

Wennmacker SZ, Lamberts MP, Di Martino M, Drenth JP, Gurusamy KS, van Laarhoven CJ (2018) Transabdominal ultrasound and endoscopic ultrasound for diagnosis of gallbladder polyps. Cochrane Database Syst Rev 8:CD012233. https://doi.org/10.1002/14651858.CD012233.pub2

69.

Yoshioka M, Watanabe G, Uchinami H, Miyazawa H, Abe Y, Ishiyama K, Hashimoto M, Nakamura A, Yamamoto Y (2013) Diffusion-weighted MRI for differential diagnosis in gallbladder lesions with special reference to ADC cut-off values. Hepatogastroenterology 60 (124):692–698

70.

Yoshimitsu K, Honda H, Kaneko K, Kuroiwa T, Irie H, Ueki T, Chijiiwa K, Takenaka K, Masuda K (1997) Dynamic MRI of the gallbladder lesions: differentiation of benign from malignant. J Magn Reson Imaging 7 (4):696–701. https://doi.org/10.1002/jmri.1880070415

71.

Zhou W, Li G, Ren L (2017) Triphasic Dynamic Contrast-Enhanced Computed Tomography in the Differentiation of Benign and Malignant Gallbladder Polypoid Lesions. J Am Coll Surg 225 (2):243–248. https://doi.org/10.1016/j.jamcollsurg.2017.04.014

72.

Song ER, Chung WS, Jang HY, Yoon M, Cha EJ (2014) CT differentiation of 1–2-cm gallbladder polyps: benign vs malignant. Abdom Imaging 39 (2):334–341. https://doi.org/10.1007/s00261-013-0071-z

73.

Tao J, Zhang Y, Chen H, Wang S, Sun Q, Zhang W, Liu Q, Mai X, Yu D (2020) Triphasic dynamic contrast-enhanced computed tomography predictive model of benign and malignant risk of gallbladder occupying lesions. Medicine (Baltimore) 99 (13):e19539. https://doi.org/10.1097/MD.0000000000019539

74.

Zhou D, Wang JD, Yang Y, Yu WL, Zhang YJ, Quan ZW (2016) Individualized nomogram improves diagnostic accuracy of stage I-II gallbladder cancer in chronic cholecystitis patients with gallbladder wall thickening. Hepatobiliary Pancreat Dis Int 15 (2):180–188. https://doi.org/10.1016/s1499-3872(16)60073-5

75.

Chen M, Cao J, Bai Y, Tong C, Lin J, Jindal V, Barchi LC, Nadalin S, Yang SX, Pesce A, Panaro F, Ariche A, Kai K, Memeo R, Bekaii-Saab T, Cai X, Written on behalf of the AMEGCCG (2019) Development and Validation of a Nomogram for Early Detection of Malignant Gallbladder Lesions. Clin Transl Gastroenterol 10 (10):e00098. https://doi.org/10.14309/ctg.0000000000000098

76.

Bonatti M, Vezzali N, Lombardo F, Ferro F, Zamboni G, Tauber M, Bonatti G (2017) Gallbladder adenomyomatosis: imaging findings, tricks and pitfalls. Insights Imaging 8 (2):243–253. https://doi.org/10.1007/s13244-017-0544-7

77.

Pellino G, Sciaudone G, Candilio G, Perna G, Santoriello A, Canonico S, Selvaggi F (2013) Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review. Hepatobiliary Pancreat Dis Int 12 (2):136–142. https://doi.org/10.1016/s1499-3872(13)60022-3

78.

Yoon JH, Cha SS, Han SS, Lee SJ, Kang MS (2006) Gallbladder adenomyomatosis: imaging findings. Abdom Imaging 31 (5):555–563. https://doi.org/10.1007/s00261-005-0230-y

79.

Hwang JI, Chou YH, Tsay SH, Chiang JH, Chang CY, Boland GW, Mueller PR (1998) Radiologic and pathologic correlation of adenomyomatosis of the gallbladder. Abdom Imaging 23 (1):73–77. https://doi.org/10.1007/s002619900288

80.

Nabatame N, Shirai Y, Nishimura A, Yokoyama N, Wakai T, Hatakeyama K (2004) High risk of gallbladder carcinoma in elderly patients with segmental adenomyomatosis of the gallbladder. J Exp Clin Cancer Res 23 (4):593–598

81.

Albores-Saavedra J, Shukla D, Carrick K, Henson DE (2004) In situ and invasive adenocarcinomas of the gallbladder extending into or arising from Rokitansky-Aschoff sinuses: a clinicopathologic study of 49 cases. Am J Surg Pathol 28 (5):621–628. https://doi.org/10.1097/00000478-200405000-00009

82.

Ootani T, Shirai Y, Tsukada K, Muto T (1992) Relationship between gallbladder carcinoma and the segmental type of adenomyomatosis of the gallbladder. Cancer 69 (11):2647–2652. https://doi.org/10.1002/1097-0142(19920601)69:11<2647::aid-cncr2820691105>3.0.co;2-0

83.

Boscak AR, Al-Hawary M, Ramsburgh SR (2006) Best cases from the AFIP: Adenomyomatosis of the gallbladder. Radiographics 26 (3):941–946. https://doi.org/10.1148/rg.263055180

84.

Chao C, Hsiao HC, Wu CS, Wang KC (1992) Computed tomographic finding in adenomyomatosis of the gallbladder. J Formos Med Assoc 91 (4):467–469

85.

Yang HK, Lee JM, Yu MH, Lee SM, Park J, Han NY, Lee K, Jang JY, Han JK (2018) CT diagnosis of gallbladder adenomyomatosis: importance of enhancing mucosal epithelium, the "cotton ball sign". Eur Radiol 28 (9):3573–3582. https://doi.org/10.1007/s00330-018-5412-4

86.

Hammad AY, Miura JT, Turaga KK, Johnston FM, Hohenwalter MD, Gamblin TC (2016) A literature review of radiological findings to guide the diagnosis of gallbladder adenomyomatosis. HPB (Oxford) 18 (2):129–135. https://doi.org/10.1016/j.hpb.2015.09.006

87.

Haradome H, Ichikawa T, Sou H, Yoshikawa T, Nakamura A, Araki T, Hachiya J (2003) The pearl necklace sign: an imaging sign of adenomyomatosis of the gallbladder at MR cholangiopancreatography. Radiology 227 (1):80–88. https://doi.org/10.1148/radiol.2271011378

88.

Cariati A, Cetta F (2003) Rokitansky-Aschoff sinuses of the gallbladder are associated with black pigment gallstone formation: a scanning electron microscopy study. Ultrastruct Pathol 27 (4):265–270. https://doi.org/10.1080/01913120309913

89.

Moon J, Shin YC, Heo TG, Choi PW, Kim JI, Jung SW, Jun H, Jung SM, Um E (2019) Differentiation of gallbladder adenomyomatosis from early-stage gallbladder cancer before surgery. Ann Hepatobiliary Pancreat Surg 23 (4):334–338. https://doi.org/10.14701/ahbps.2019.23.4.334

90.

Goodman ZD, Ishak KG (1981) Xanthogranulomatous cholecystitis. Am J Surg Pathol 5 (7):653–659. https://doi.org/10.1097/00000478-198110000-00007

91.

Roberts KM, Parsons MA (1987) Xanthogranulomatous cholecystitis: clinicopathological study of 13 cases. J Clin Pathol 40 (4):412–417. https://doi.org/10.1136/jcp.40.4.412

92.

Hale MD, Roberts KJ, Hodson J, Scott N, Sheridan M, Toogood GJ (2014) Xanthogranulomatous cholecystitis: a European and global perspective. HPB (Oxford) 16 (5):448–458. https://doi.org/10.1111/hpb.12152

93.

Parra JA, Acinas O, Bueno J, Guezmes A, Fernandez MA, Farinas MC (2000) Xanthogranulomatous cholecystitis: clinical, sonographic, and CT findings in 26 patients. AJR Am J Roentgenol 174 (4):979–983. https://doi.org/10.2214/ajr.174.4.1740979

94.

Casas D, Perez-Andres R, Jimenez JA, Mariscal A, Cuadras P, Salas M, Gomez-Plaza MC (1996) Xanthogranulomatous cholecystitis: a radiological study of 12 cases and a review of the literature. Abdom Imaging 21 (5):456–460. https://doi.org/10.1007/s002619900104

95.

Ito R, Kobayashi T, Ogasawara G, Kono Y, Mori K, Kawasaki S (2020) A scoring system based on computed tomography for the correct diagnosis of xanthogranulomatous cholecystitis. Acta Radiol Open 9 (4):2058460120918237. https://doi.org/10.1177/2058460120918237

96.

Kang TW, Kim SH, Park HJ, Lim S, Jang KM, Choi D, Lee SJ (2013) Differentiating xanthogranulomatous cholecystitis from wall-thickening type of gallbladder cancer: added value of diffusion-weighted MRI. Clin Radiol 68 (10):992–1001. https://doi.org/10.1016/j.crad.2013.03.022

97.

Shuto R, Kiyosue H, Komatsu E, Matsumoto S, Kawano K, Kondo Y, Yokoyama S, Mori H (2004) CT and MR imaging findings of xanthogranulomatous cholecystitis: correlation with pathologic findings. Eur Radiol 14 (3):440–446. https://doi.org/10.1007/s00330-003-1931-7

98.

Lee ES, Kim JH, Joo I, Lee JY, Han JK, Choi BI (2015) Xanthogranulomatous cholecystitis: diagnostic performance of US, CT, and MRI for differentiation from gallbladder carcinoma. Abdom Imaging 40 (7):2281–2292. https://doi.org/10.1007/s00261-015-0432-x

99.

Gupta V, Vishnu KS, Yadav TD, Sakaray YR, Irrinki S, Mittal BR, Kalra N, Vaiphei K (2019) Radio-pathological Correlation of 18F-FDG PET in Characterizing Gallbladder Wall Thickening. J Gastrointest Cancer 50 (4):901–906. https://doi.org/10.1007/s12029-018-0176-2

100.

Oe A, Kawabe J, Torii K, Kawamura E, Higashiyama S, Kotani J, Hayashi T, Kurooka H, Tsumoto C, Kubo S, Shiomi S (2006) Distinguishing benign from malignant gallbladder wall thickening using FDG-PET. Ann Nucl Med 20 (10):699–703. https://doi.org/10.1007/BF02984683

101.

Rodriguez-Fernandez A, Gomez-Rio M, Llamas-Elvira JM, Ortega-Lozano S, Ferron-Orihuela JA, Ramia-Angel JM, Mansilla-Rosello A, Martinez-del-Valle MD, Ramos-Font C (2004) Positron-emission tomography with fluorine-18-fluoro-2-deoxy-D-glucose for gallbladder cancer diagnosis. Am J Surg 188 (2):171–175. https://doi.org/10.1016/j.amjsurg.2003.12.070

102.

Annunziata S, Pizzuto DA, Caldarella C, Galiandro F, Sadeghi R, Treglia G (2015) Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in gallbladder cancer: A meta-analysis. World J Gastroenterol 21 (40):11481–11488. https://doi.org/10.3748/wjg.v21.i40.11481

103.

Sons HU, Borchard F, Joel BS (1985) Carcinoma of the gallbladder: autopsy findings in 287 cases and review of the literature. J Surg Oncol 28 (3):199–206. https://doi.org/10.1002/jso.2930280311

104.

Piehler JM, Crichlow RW (1978) Primary carcinoma of the gallbladder. Surg Gynecol Obstet 147 (6):929–942

105.

Fahim RB, Mc DJ, Richards JC, Ferris DO (1962) Carcinoma of the gallbladder: a study of its modes of spread. Ann Surg 156:114–124. https://doi.org/10.1097/00000658-196207000-00021

106.

Nagakawa T, Mori K, Nakano T, Kadoya M, Kobayashi H, Akiyama T, Kayahara M, Ohta T, Ueno K, Higashino Y, et al. (1993) Perineural invasion of carcinoma of the pancreas and biliary tract. Br J Surg 80 (5):619–621. https://doi.org/10.1002/bjs.1800800526

107.

Midorikawa Y, Kubota K, Komatsu Y, Hasegawa K, Koike Y, Mori M, Makuuchi M (2000) Gallbladder carcinoma with a tumor thrombus in the common bile duct: an unusual cause of obstructive jaundice. Surgery 127 (4):473–474. https://doi.org/10.1067/msy.2000.102421

108.

Ito M, Mishima Y, Sato T (1991) An anatomical study of the lymphatic drainage of the gallbladder. Surg Radiol Anat 13 (2):89–104. https://doi.org/10.1007/BF01623880

109.

Kim J, Ryu JK, Kim C, Paeng JC, Kim YT (2014) Is there any role of positron emission tomography computed tomography for predicting resectability of gallbladder cancer? J Korean Med Sci 29 (5):680–684. https://doi.org/10.3346/jkms.2014.29.5.680

110.

Bach AM, Loring LA, Hann LE, Illescas FF, Fong Y, Blumgart LH (1998) Gallbladder cancer: can ultrasonography evaluate extent of disease? J Ultrasound Med 17 (5):303–309. https://doi.org/10.7863/jum.1998.17.5.303

111.

Ohtani T, Shirai Y, Tsukada K, Muto T, Hatakeyama K (1996) Spread of gallbladder carcinoma: CT evaluation with pathologic correlation. Abdom Imaging 21 (3):195–201. https://doi.org/10.1007/s002619900045

112.

Li B, Xu XX, Du Y, Yang HF, Li Y, Zhang Q, Xiao DM, Huang YY, Meng J, Wang WX (2013) Computed tomography for assessing resectability of gallbladder carcinoma: a systematic review and meta-analysis. Clin Imaging 37 (2):327–333. https://doi.org/10.1016/j.clinimag.2012.05.009

113.

Kim JH, Kim TK, Eun HW, Kim BS, Lee MG, Kim PN, Ha HK (2002) Preoperative evaluation of gallbladder carcinoma: efficacy of combined use of MR imaging, MR cholangiography, and contrast-enhanced dual-phase three-dimensional MR angiography. J Magn Reson Imaging 16 (6):676–684. https://doi.org/10.1002/jmri.10212

114.

Tseng JH, Wan YL, Hung CF, Ng KK, Pan KT, Chou AS, Liu NJ (2002) Diagnosis and staging of gallbladder carcinoma. Evaluation with dynamic MR imaging. Clin Imaging 26 (3):177–182. https://doi.org/10.1016/s0899-7071(01)00409-0

115.

Arslan E, Aksoy T, Dursun N, Gursu RU, Sevinc MM, Cermik TF (2020) The Role of 18F-FDG PET/CT in staging of gallbladder carcinomas. Turk J Gastroenterol 31 (2):105–112. https://doi.org/10.5152/tjg.2020.19410

116.

Ma KW, Cheung TT, She WH, Chok KSH, Chan ACY, Dai WC, Chiu WH, Lo CM (2018) Diagnostic and Prognostic Role of 18-FDG PET/CT in the Management of Resectable Biliary Tract Cancer. World J Surg 42 (3):823–834. https://doi.org/10.1007/s00268-017-4192-3

117.

Lee SW, Kim HJ, Park JH, Park DI, Cho YK, Sohn CI, Jeon WK, Kim BI (2010) Clinical usefulness of 18F-FDG PET-CT for patients with gallbladder cancer and cholangiocarcinoma. J Gastroenterol 45 (5):560–566. https://doi.org/10.1007/s00535-009-0188-6

118.

Kanlioz M, Ekici U, Ayva Y (2019) Analysis of Incidental Gallbladder Cancer in Cholecystectomies. Cureus 11 (9):e5710. https://doi.org/10.7759/cureus.5710

119.

Margonis GA, Gani F, Buettner S, Amini N, Sasaki K, Andreatos N, Ethun CG, Poultsides G, Tran T, Idrees K, Isom CA, Fields RC, Krasnick B, Weber SM, Salem A, Martin RC, Scoggins C, Shen P, Mogal HD, Schmidt C, Beal E, Hatzaras I, Shenoy R, Maithel SK, Pawlik TM (2016) Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium. HPB (Oxford) 18 (11):872–878. https://doi.org/10.1016/j.hpb.2016.05.016

120.

Kim TG (2017) Patterns of initial failure after resection for gallbladder cancer: implications for adjuvant radiotherapy. Radiat Oncol J 35 (4):359–367. https://doi.org/10.3857/roj.2017.00388

121.

Wiggers JK, Groot Koerkamp B, Ovadia Z, Busch OR, Gouma DJ, van Gulik TM (2014) Patterns of recurrence after resection of gallbladder cancer without routine extrahepatic bile duct resection. HPB (Oxford) 16 (7):635–640. https://doi.org/10.1111/hpb.12188

122.

Jarnagin WR, Ruo L, Little SA, Klimstra D, D'Angelica M, DeMatteo RP, Wagman R, Blumgart LH, Fong Y (2003) Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: implications for adjuvant therapeutic strategies. Cancer 98 (8):1689–1700. https://doi.org/10.1002/cncr.11699

123.

National Comprehensive Cancer Network (NCCN). NCCN clinical practice guidelines in oncology. https://www.nccn.org/professionals/physician_gls.

Title: Current update on gallbladder carcinoma
Authors: Dhakshinamoorthy Ganeshan
Avinash Kambadakone
Paul Nikolaidis
Vivek Subbiah
Ishwaria M. Subbiah
Catherine Devine
Publication date: 01-06-2021
Publisher: Springer US
Keywords: Ultrasound
Ultrasound
Published in: Abdominal Radiology / Issue 6/2021
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-020-02871-2

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