Published in:
Open Access
01-08-2019 | Crohn's Disease | Hollow Organ GI
Evaluating the inflammatory activity in Crohn’s disease using magnetic resonance diffusion kurtosis imaging
Authors:
Jingyun Cheng, Ke Wang, Xiaoyuan Leng, Yan Wang, Guobin Xu, Guangyao Wu
Published in:
Abdominal Radiology
|
Issue 8/2019
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Abstract
Objectives
To explore the feasibility of diffusion kurtosis imaging (DKI) for evaluating inflammatory activity in Crohn’s disease (CD).
Materials and methods
In all, 51 CD patients were included, who were performed with consecutive enteroscopy, MR and DKI (b values = 0–2000 mm2/s). The lesions of bowel segments were graded as inactive (0–2), mild (3–6), and moderate–severe group (> 6) based on simplified endoscopic activity score for Crohn’s disease (SES-CD), The abilities of the parameters of DKI and DWI in grading different activity lesions were compared.
Results
One hundred and twenty-seven bowel segments including inactive (15), mild (45) and moderate–severe (67) were analyzed. ADC (r = − 0.627, p < 0.001), Dapp (r = − 0.381, p < 0.001) and Kapp (r = 0.641, p < 0.001) were correlated with SES-CD. These parameters were significantly different among the three groups (all p < 0.001). ROC analysis found ADC had the highest accuracy (AUC = 0.884, p < 0.001) to differentiate inactive from active group with the threshold at 0.865 × 10−3 mm2/s, which was slightly higher than Kapp (AUC = 0.867, p < 0.001) with the threshold at 0.645, and was obviously higher than Dapp (AUC = 0.726, p = 0.005). Similarly, ADC also had the highest accuracy (AUC = 0.846, p < 0.001) to differentiate inactive–mild from moderate–severe group with the threshold at 0.825 × 10−3 mm2/s, and minimally higher than Kapp (AUC = 0.843, p < 0.001) with the threshold at 0.695, and obviously higher than Dapp (AUC = 0.690, p < 0.001).
Conclusion
DKI is feasible and comparable to conventional DWI for the evaluation of inflammatory activity in CD.