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Published in: Abdominal Radiology 10/2017

01-10-2017 | Pictorial Essay

Fertility-sparing for young patients with gynecologic cancer: How MRI can guide patient selection prior to conservative management

Authors: Sinead H. McEvoy, Stephanie Nougaret, Nadeem R. Abu-Rustum, Hebert Alberto Vargas, Elizabeth A. Sadowski, Christine O. Menias, Fuki Shitano, Shinya Fujii, Ramon E. Sosa, Joanna G. Escalon, Evis Sala, Yulia Lakhman

Published in: Abdominal Radiology | Issue 10/2017

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Abstract

Historically, cancer treatment has emphasized measures for the “cure” regardless of the long-term consequences. Advances in cancer detection and treatment have resulted in improved outcomes bringing to the fore various quality of life considerations including future fertility. For many young cancer patients, fertility preservation is now an integral component of clinical decision-making and treatment design. Optimal fertility-sparing options for young patients with gynecologic cancer are influenced by patient age, primary cancer, treatment regimens, and patient preferences. Possible approaches include embryo or oocyte cryopreservation, ovarian transposition, conservative surgery, and conservative medical treatment to delay radical surgery. These may be used alone or in combination to maximize fertility preservation. Awareness of the various fertility-sparing options, eligibility criteria, and the central role of magnetic resonance imaging in the proper selection of patients will enable radiologists to produce complete clinically relevant imaging reports and serve as effective consultants to referring clinicians. Knowledge of the potential imaging pitfalls is essential to avoid misinterpretation and guide appropriate management.
Literature
1.
3.
go back to reference Carter J, Rowland K, Chi D, et al. (2005) Gynecologic cancer treatment and the impact of cancer-related infertility. Gynecol Oncol 97(1):90–95PubMedCrossRef Carter J, Rowland K, Chi D, et al. (2005) Gynecologic cancer treatment and the impact of cancer-related infertility. Gynecol Oncol 97(1):90–95PubMedCrossRef
4.
go back to reference Loren AW, Mangu PB, Beck LN, et al. (2013) Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 31(19):2500–2510PubMedPubMedCentralCrossRef Loren AW, Mangu PB, Beck LN, et al. (2013) Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 31(19):2500–2510PubMedPubMedCentralCrossRef
6.
go back to reference Sala E, Rockall AG, Freeman SJ, Mitchell DG, Reinhold C (2013) The added role of MR imaging in treatment stratification of patients with gynecologic malignancies: what the radiologist needs to know. Radiology 266(3):717–740PubMedCrossRef Sala E, Rockall AG, Freeman SJ, Mitchell DG, Reinhold C (2013) The added role of MR imaging in treatment stratification of patients with gynecologic malignancies: what the radiologist needs to know. Radiology 266(3):717–740PubMedCrossRef
7.
go back to reference Kinkel K, Lu Y, Mehdizade A, Pelte MF, Hricak H (2005) Indeterminate ovarian mass at US: incremental value of second imaging test for characterization—meta-analysis and Bayesian analysis. Radiology 236(1):85–94PubMedCrossRef Kinkel K, Lu Y, Mehdizade A, Pelte MF, Hricak H (2005) Indeterminate ovarian mass at US: incremental value of second imaging test for characterization—meta-analysis and Bayesian analysis. Radiology 236(1):85–94PubMedCrossRef
8.
go back to reference Noyes N, Knopman JM, Long K, Coletta JM, Abu-Rustum NR (2011) Fertility considerations in the management of gynecologic malignancies. Gynecol Oncol 120(3):326–333PubMedCrossRef Noyes N, Knopman JM, Long K, Coletta JM, Abu-Rustum NR (2011) Fertility considerations in the management of gynecologic malignancies. Gynecol Oncol 120(3):326–333PubMedCrossRef
9.
go back to reference Practice Committee of the American Society for Reproductive Medicine (2014) Ovarian tissue cryopreservation: a committee opinion. Fertil Steril 101(5):1237–1243CrossRef Practice Committee of the American Society for Reproductive Medicine (2014) Ovarian tissue cryopreservation: a committee opinion. Fertil Steril 101(5):1237–1243CrossRef
10.
go back to reference Bastings L, Beerendonk CC, Westphal JR, et al. (2013) Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review. Hum Reprod Update 19(5):483–506PubMedCrossRef Bastings L, Beerendonk CC, Westphal JR, et al. (2013) Autotransplantation of cryopreserved ovarian tissue in cancer survivors and the risk of reintroducing malignancy: a systematic review. Hum Reprod Update 19(5):483–506PubMedCrossRef
11.
go back to reference Baron KT, Babagbemi KT, Arleo EK, Asrani AV, Troiano RN (2013) Emergent complications of assisted reproduction: expecting the unexpected. Radiographics 33(1):229–244PubMedCrossRef Baron KT, Babagbemi KT, Arleo EK, Asrani AV, Troiano RN (2013) Emergent complications of assisted reproduction: expecting the unexpected. Radiographics 33(1):229–244PubMedCrossRef
12.
go back to reference Zivi E, Simon A, Laufer N (2010) Ovarian hyperstimulation syndrome: definition, incidence, and classification. Semin Reprod Med 28(6):441–447PubMedCrossRef Zivi E, Simon A, Laufer N (2010) Ovarian hyperstimulation syndrome: definition, incidence, and classification. Semin Reprod Med 28(6):441–447PubMedCrossRef
13.
go back to reference Kim IY, Lee BH (1997) Ovarian hyperstimulation syndrome. US and CT appearances. Clin Imaging 21(4):284–286PubMedCrossRef Kim IY, Lee BH (1997) Ovarian hyperstimulation syndrome. US and CT appearances. Clin Imaging 21(4):284–286PubMedCrossRef
14.
go back to reference Jung SE, Byun JY, Lee JM, et al. (2001) MR imaging of maternal diseases in pregnancy. AJR Am J Roentgenol 177(6):1293–1300PubMedCrossRef Jung SE, Byun JY, Lee JM, et al. (2001) MR imaging of maternal diseases in pregnancy. AJR Am J Roentgenol 177(6):1293–1300PubMedCrossRef
15.
go back to reference Gelbaya TA (2010) Short and long-term risks to women who conceive through in vitro fertilization. Hum Fertil (Camb Engl) 13(1):19–27CrossRef Gelbaya TA (2010) Short and long-term risks to women who conceive through in vitro fertilization. Hum Fertil (Camb Engl) 13(1):19–27CrossRef
16.
go back to reference Zhang FL, Fu LL, Yang Y (2016) Both thromboembolic stroke and cerebral venous thrombosis resulting from Ovarian Hyperstimulation Syndrome (OHSS). J Obstet Gynaecol 36(2):267–268PubMedCrossRef Zhang FL, Fu LL, Yang Y (2016) Both thromboembolic stroke and cerebral venous thrombosis resulting from Ovarian Hyperstimulation Syndrome (OHSS). J Obstet Gynaecol 36(2):267–268PubMedCrossRef
17.
go back to reference Wallace WH, Thomson AB, Saran F, Kelsey TW (2005) Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys 62(3):738–744PubMedCrossRef Wallace WH, Thomson AB, Saran F, Kelsey TW (2005) Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys 62(3):738–744PubMedCrossRef
18.
go back to reference Wallace WH, Anderson RA, Irvine DS (2005) Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol 6(4):209–218PubMedCrossRef Wallace WH, Anderson RA, Irvine DS (2005) Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol 6(4):209–218PubMedCrossRef
19.
go back to reference Milgrom SA, Vargas HA, Sala E, et al. (2013) Acute effects of pelvic irradiation on the adult uterus revealed by dynamic contrast-enhanced MRI. Br J Radiol 86(1031):20130334PubMedPubMedCentralCrossRef Milgrom SA, Vargas HA, Sala E, et al. (2013) Acute effects of pelvic irradiation on the adult uterus revealed by dynamic contrast-enhanced MRI. Br J Radiol 86(1031):20130334PubMedPubMedCentralCrossRef
20.
go back to reference Green DM, Sklar CA, Boice JD Jr, et al. (2009) Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. J Clin Oncol 27(14):2374–2381PubMedPubMedCentralCrossRef Green DM, Sklar CA, Boice JD Jr, et al. (2009) Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. J Clin Oncol 27(14):2374–2381PubMedPubMedCentralCrossRef
21.
go back to reference Irtan S, Orbach D, Helfre S, Sarnacki S (2013) Ovarian transposition in prepubescent and adolescent girls with cancer. Lancet Oncol 14(13):e601–e608PubMedCrossRef Irtan S, Orbach D, Helfre S, Sarnacki S (2013) Ovarian transposition in prepubescent and adolescent girls with cancer. Lancet Oncol 14(13):e601–e608PubMedCrossRef
22.
go back to reference Oliver Perez MR, Magrina J, Garcia AT, Jimenez Lopez JS (2015) Prophylactic salpingectomy and prophylactic salpingoophorectomy for adnexal high-grade serous epithelial carcinoma: a reappraisal. Surg Oncol 24(4):335–344PubMedCrossRef Oliver Perez MR, Magrina J, Garcia AT, Jimenez Lopez JS (2015) Prophylactic salpingectomy and prophylactic salpingoophorectomy for adnexal high-grade serous epithelial carcinoma: a reappraisal. Surg Oncol 24(4):335–344PubMedCrossRef
23.
go back to reference Gubbala K, Laios A, Gallos I, et al. (2014) Outcomes of ovarian transposition in gynaecological cancers; a systematic review and meta-analysis. J Ovarian Res 7:69PubMedPubMedCentralCrossRef Gubbala K, Laios A, Gallos I, et al. (2014) Outcomes of ovarian transposition in gynaecological cancers; a systematic review and meta-analysis. J Ovarian Res 7:69PubMedPubMedCentralCrossRef
24.
go back to reference Yamamoto R, Okamoto K, Yukiharu T, et al. (2001) A study of risk factors for ovarian metastases in stage Ib-IIIb cervical carcinoma and analysis of ovarian function after a transposition. Gynecol Oncol 82(2):312–316PubMedCrossRef Yamamoto R, Okamoto K, Yukiharu T, et al. (2001) A study of risk factors for ovarian metastases in stage Ib-IIIb cervical carcinoma and analysis of ovarian function after a transposition. Gynecol Oncol 82(2):312–316PubMedCrossRef
25.
go back to reference Sella T, Mironov S, Hricak H (2005) Imaging of transposed ovaries in patients with cervical carcinoma. AJR Am J Roentgenol 184(5):1602–1610PubMedCrossRef Sella T, Mironov S, Hricak H (2005) Imaging of transposed ovaries in patients with cervical carcinoma. AJR Am J Roentgenol 184(5):1602–1610PubMedCrossRef
26.
go back to reference Ulaner GA, Lyall A (2013) Identifying and distinguishing treatment effects and complications from malignancy at FDG PET/CT. Radiographics 33(6):1817–1834PubMedCrossRef Ulaner GA, Lyall A (2013) Identifying and distinguishing treatment effects and complications from malignancy at FDG PET/CT. Radiographics 33(6):1817–1834PubMedCrossRef
27.
go back to reference Forstner R, Thomassin-Naggara I, Cunha TM, et al. (2016) ESUR recommendations for MR imaging of the sonographically indeterminate adnexal mass: an update. Eur Radiol 27:2248–2257PubMedPubMedCentralCrossRef Forstner R, Thomassin-Naggara I, Cunha TM, et al. (2016) ESUR recommendations for MR imaging of the sonographically indeterminate adnexal mass: an update. Eur Radiol 27:2248–2257PubMedPubMedCentralCrossRef
28.
go back to reference Spencer JA, Ghattamaneni S (2010) MR imaging of the sonographically indeterminate adnexal mass. Radiology 256(3):677–694PubMedCrossRef Spencer JA, Ghattamaneni S (2010) MR imaging of the sonographically indeterminate adnexal mass. Radiology 256(3):677–694PubMedCrossRef
29.
go back to reference de Souza NM, Dina R, McIndoe GA, Soutter WP (2006) Cervical cancer: value of an endovaginal coil magnetic resonance imaging technique in detecting small volume disease and assessing parametrial extension. Gynecol Oncol 102(1):80–85CrossRef de Souza NM, Dina R, McIndoe GA, Soutter WP (2006) Cervical cancer: value of an endovaginal coil magnetic resonance imaging technique in detecting small volume disease and assessing parametrial extension. Gynecol Oncol 102(1):80–85CrossRef
30.
go back to reference Downey K, Attygalle AD, Morgan VA, et al. (2016) Comparison of optimised endovaginal vs external array coil T2-weighted and diffusion-weighted imaging techniques for detecting suspected early-stage (IA/IB1) uterine cervical cancer. Eur Radiol 26(4):941–950PubMedCrossRef Downey K, Attygalle AD, Morgan VA, et al. (2016) Comparison of optimised endovaginal vs external array coil T2-weighted and diffusion-weighted imaging techniques for detecting suspected early-stage (IA/IB1) uterine cervical cancer. Eur Radiol 26(4):941–950PubMedCrossRef
31.
go back to reference Downey K, Jafar M, Attygalle AD, et al. (2013) Influencing surgical management in patients with carcinoma of the cervix using a T2- and ZOOM-diffusion-weighted endovaginal MRI technique. Br J Cancer 109(3):615–622PubMedPubMedCentralCrossRef Downey K, Jafar M, Attygalle AD, et al. (2013) Influencing surgical management in patients with carcinoma of the cervix using a T2- and ZOOM-diffusion-weighted endovaginal MRI technique. Br J Cancer 109(3):615–622PubMedPubMedCentralCrossRef
32.
go back to reference Downey K, Shepherd JH, Attygalle AD, et al. (2014) Preoperative imaging in patients undergoing trachelectomy for cervical cancer: validation of a combined T2- and diffusion-weighted endovaginal MRI technique at 3.0 T. Gynecol Oncol 133(2):326–332PubMedPubMedCentralCrossRef Downey K, Shepherd JH, Attygalle AD, et al. (2014) Preoperative imaging in patients undergoing trachelectomy for cervical cancer: validation of a combined T2- and diffusion-weighted endovaginal MRI technique at 3.0 T. Gynecol Oncol 133(2):326–332PubMedPubMedCentralCrossRef
33.
go back to reference Balleyguier C, Sala E, Da Cunha T, et al. (2011) Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology. Eur Radiol 21(5):1102–1110PubMedCrossRef Balleyguier C, Sala E, Da Cunha T, et al. (2011) Staging of uterine cervical cancer with MRI: guidelines of the European Society of Urogenital Radiology. Eur Radiol 21(5):1102–1110PubMedCrossRef
34.
go back to reference Kinkel K, Forstner R, Danza FM, et al. (2009) Staging of endometrial cancer with MRI: guidelines of the European Society of Urogenital Imaging. Eur Radiol 19(7):1565–1574PubMedCrossRef Kinkel K, Forstner R, Danza FM, et al. (2009) Staging of endometrial cancer with MRI: guidelines of the European Society of Urogenital Imaging. Eur Radiol 19(7):1565–1574PubMedCrossRef
35.
go back to reference Charles-Edwards EM, Messiou C, Morgan VA, et al. (2008) Diffusion-weighted imaging in cervical cancer with an endovaginal technique: potential value for improving tumor detection in stage Ia and Ib1 disease. Radiology 249(2):541–550PubMedCrossRef Charles-Edwards EM, Messiou C, Morgan VA, et al. (2008) Diffusion-weighted imaging in cervical cancer with an endovaginal technique: potential value for improving tumor detection in stage Ia and Ib1 disease. Radiology 249(2):541–550PubMedCrossRef
36.
go back to reference Nougaret S, Tirumani SH, Addley H, et al. (2013) Pearls and pitfalls in MRI of gynecologic malignancy with diffusion-weighted technique. AJR Am J Roentgenol 200(2):261–276PubMedCrossRef Nougaret S, Tirumani SH, Addley H, et al. (2013) Pearls and pitfalls in MRI of gynecologic malignancy with diffusion-weighted technique. AJR Am J Roentgenol 200(2):261–276PubMedCrossRef
37.
go back to reference Akita A, Shinmoto H, Hayashi S, et al. (2011) Comparison of T2-weighted and contrast-enhanced T1-weighted MR imaging at 1.5 T for assessing the local extent of cervical carcinoma. Eur Radiol 21(9):1850–1857PubMedCrossRef Akita A, Shinmoto H, Hayashi S, et al. (2011) Comparison of T2-weighted and contrast-enhanced T1-weighted MR imaging at 1.5 T for assessing the local extent of cervical carcinoma. Eur Radiol 21(9):1850–1857PubMedCrossRef
38.
go back to reference Sala E, Crawford R, Senior E, et al. (2009) Added value of dynamic contrast-enhanced magnetic resonance imaging in predicting advanced stage disease in patients with endometrial carcinoma. Int J Gynecol Cancer 19(1):141–146PubMedCrossRef Sala E, Crawford R, Senior E, et al. (2009) Added value of dynamic contrast-enhanced magnetic resonance imaging in predicting advanced stage disease in patients with endometrial carcinoma. Int J Gynecol Cancer 19(1):141–146PubMedCrossRef
39.
go back to reference Thomassin-Naggara I, Balvay D, Aubert E, et al. (2012) Quantitative dynamic contrast-enhanced MR imaging analysis of complex adnexal masses: a preliminary study. Eur Radiol 22(4):738–745PubMedCrossRef Thomassin-Naggara I, Balvay D, Aubert E, et al. (2012) Quantitative dynamic contrast-enhanced MR imaging analysis of complex adnexal masses: a preliminary study. Eur Radiol 22(4):738–745PubMedCrossRef
40.
go back to reference Thomassin-Naggara I, Aubert E, Rockall A, et al. (2013) Adnexal masses: development and preliminary validation of an MR imaging scoring system. Radiology 267(2):432–443PubMedCrossRef Thomassin-Naggara I, Aubert E, Rockall A, et al. (2013) Adnexal masses: development and preliminary validation of an MR imaging scoring system. Radiology 267(2):432–443PubMedCrossRef
41.
go back to reference Thomassin-Naggara I, Balvay D, Rockall A, et al. (2015) Added value of assessing adnexal masses with advanced MRI techniques. Biomed Res Int 2015:785206PubMedPubMedCentralCrossRef Thomassin-Naggara I, Balvay D, Rockall A, et al. (2015) Added value of assessing adnexal masses with advanced MRI techniques. Biomed Res Int 2015:785206PubMedPubMedCentralCrossRef
42.
go back to reference Thomassin-Naggara I, Toussaint I, Perrot N, et al. (2011) Characterization of complex adnexal masses: value of adding perfusion- and diffusion-weighted MR imaging to conventional MR imaging. Radiology 258(3):793–803PubMedCrossRef Thomassin-Naggara I, Toussaint I, Perrot N, et al. (2011) Characterization of complex adnexal masses: value of adding perfusion- and diffusion-weighted MR imaging to conventional MR imaging. Radiology 258(3):793–803PubMedCrossRef
43.
go back to reference American Cancer Society (2015) Global cancer facts & figures, 3rd edn. Atlanta: American Cancer Society American Cancer Society (2015) Global cancer facts & figures, 3rd edn. Atlanta: American Cancer Society
45.
go back to reference Covens A, Rosen B, Murphy J, et al. (2002) How important is removal of the parametrium at surgery for carcinoma of the cervix? Gynecol Oncol 84(1):145–149PubMedCrossRef Covens A, Rosen B, Murphy J, et al. (2002) How important is removal of the parametrium at surgery for carcinoma of the cervix? Gynecol Oncol 84(1):145–149PubMedCrossRef
46.
go back to reference Colombo N, Carinelli S, Colombo A, et al. (2012) Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii27–vii32PubMed Colombo N, Carinelli S, Colombo A, et al. (2012) Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii27–vii32PubMed
48.
go back to reference Bentivegna E, Gouy S, Maulard A, et al. (2016) Oncological outcomes after fertility-sparing surgery for cervical cancer: a systematic review. Lancet Oncol 17(6):e240–e253PubMedCrossRef Bentivegna E, Gouy S, Maulard A, et al. (2016) Oncological outcomes after fertility-sparing surgery for cervical cancer: a systematic review. Lancet Oncol 17(6):e240–e253PubMedCrossRef
49.
go back to reference Xu L, Sun FQ, Wang ZH (2011) Radical trachelectomy versus radical hysterectomy for the treatment of early cervical cancer: a systematic review. Acta Obstet Gynecol Scand 90(11):1200–1209PubMedCrossRef Xu L, Sun FQ, Wang ZH (2011) Radical trachelectomy versus radical hysterectomy for the treatment of early cervical cancer: a systematic review. Acta Obstet Gynecol Scand 90(11):1200–1209PubMedCrossRef
50.
go back to reference Pecorelli S, Zigliani L, Odicino F (2009) Revised FIGO staging for carcinoma of the cervix. Int J Gynaecol Obstet 105(2):107–108PubMedCrossRef Pecorelli S, Zigliani L, Odicino F (2009) Revised FIGO staging for carcinoma of the cervix. Int J Gynaecol Obstet 105(2):107–108PubMedCrossRef
51.
go back to reference Qin Y, Peng Z, Lou J, et al. (2009) Discrepancies between clinical staging and pathological findings of operable cervical carcinoma with stage IB-IIB: a retrospective analysis of 818 patients. Aust N Z J Obstet Gynaecol 49(5):542–544PubMedCrossRef Qin Y, Peng Z, Lou J, et al. (2009) Discrepancies between clinical staging and pathological findings of operable cervical carcinoma with stage IB-IIB: a retrospective analysis of 818 patients. Aust N Z J Obstet Gynaecol 49(5):542–544PubMedCrossRef
52.
go back to reference Mitchell DG, Snyder B, Coakley F, et al. (2009) Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study. Gynecol Oncol 112(1):95–103PubMedCrossRef Mitchell DG, Snyder B, Coakley F, et al. (2009) Early invasive cervical cancer: MRI and CT predictors of lymphatic metastases in the ACRIN 6651/GOG 183 intergroup study. Gynecol Oncol 112(1):95–103PubMedCrossRef
53.
go back to reference Hricak H, Gatsonis C, Coakley FV, et al. (2007) Early invasive cervical cancer: CT and MR imaging in preoperative evaluation—ACRIN/GOG comparative study of diagnostic performance and interobserver variability. Radiology 245(2):491–498PubMedCrossRef Hricak H, Gatsonis C, Coakley FV, et al. (2007) Early invasive cervical cancer: CT and MR imaging in preoperative evaluation—ACRIN/GOG comparative study of diagnostic performance and interobserver variability. Radiology 245(2):491–498PubMedCrossRef
54.
go back to reference Thomeer MG, Gerestein C, Spronk S, et al. (2013) Clinical examination versus magnetic resonance imaging in the pretreatment staging of cervical carcinoma: systematic review and meta-analysis. Eur Radiol 23(7):2005–2018PubMedCrossRef Thomeer MG, Gerestein C, Spronk S, et al. (2013) Clinical examination versus magnetic resonance imaging in the pretreatment staging of cervical carcinoma: systematic review and meta-analysis. Eur Radiol 23(7):2005–2018PubMedCrossRef
55.
go back to reference Mitchell DG, Snyder B, Coakley F, et al. (2006) Early invasive cervical cancer: tumor delineation by magnetic resonance imaging, computed tomography, and clinical examination, verified by pathologic results, in the ACRIN 6651/GOG 183 Intergroup Study. J Clin Oncol 24(36):5687–5694PubMedCrossRef Mitchell DG, Snyder B, Coakley F, et al. (2006) Early invasive cervical cancer: tumor delineation by magnetic resonance imaging, computed tomography, and clinical examination, verified by pathologic results, in the ACRIN 6651/GOG 183 Intergroup Study. J Clin Oncol 24(36):5687–5694PubMedCrossRef
56.
go back to reference Rob L, Skapa P, Robova H (2011) Fertility-sparing surgery in patients with cervical cancer. Lancet Oncol 12(2):192–200PubMedCrossRef Rob L, Skapa P, Robova H (2011) Fertility-sparing surgery in patients with cervical cancer. Lancet Oncol 12(2):192–200PubMedCrossRef
57.
go back to reference Rob L, Charvat M, Robova H, et al. (2007) Less radical fertility-sparing surgery than radical trachelectomy in early cervical cancer. Int J Gynecol Cancer 17(1):304–310PubMedCrossRef Rob L, Charvat M, Robova H, et al. (2007) Less radical fertility-sparing surgery than radical trachelectomy in early cervical cancer. Int J Gynecol Cancer 17(1):304–310PubMedCrossRef
58.
go back to reference Abu-Rustum NR, Sonoda Y (2010) Fertility-sparing surgery in early-stage cervical cancer: indications and applications. J Natl Compr Canc Netw 8(12):1435–1438PubMedCrossRef Abu-Rustum NR, Sonoda Y (2010) Fertility-sparing surgery in early-stage cervical cancer: indications and applications. J Natl Compr Canc Netw 8(12):1435–1438PubMedCrossRef
59.
go back to reference Plante M (2013) Evolution in fertility-preserving options for early-stage cervical cancer: radical trachelectomy, simple trachelectomy, neoadjuvant chemotherapy. Int J Gynecol Cancer 23(6):982–989PubMedCrossRef Plante M (2013) Evolution in fertility-preserving options for early-stage cervical cancer: radical trachelectomy, simple trachelectomy, neoadjuvant chemotherapy. Int J Gynecol Cancer 23(6):982–989PubMedCrossRef
60.
go back to reference Plante M (2015) Bulky early-stage cervical cancer (2-4 cm lesions): upfront radical trachelectomy or neoadjuvant chemotherapy followed by fertility-preserving surgery: which is the best option? Int J Gynecol Cancer 25(4):722–728PubMedCrossRef Plante M (2015) Bulky early-stage cervical cancer (2-4 cm lesions): upfront radical trachelectomy or neoadjuvant chemotherapy followed by fertility-preserving surgery: which is the best option? Int J Gynecol Cancer 25(4):722–728PubMedCrossRef
61.
go back to reference Noel P, Dube M, Plante M, St-Laurent G (2014) Early cervical carcinoma and fertility-sparing treatment options: MR imaging as a tool in patient selection and a follow-up modality. Radiographics 34(4):1099–1119PubMedCrossRef Noel P, Dube M, Plante M, St-Laurent G (2014) Early cervical carcinoma and fertility-sparing treatment options: MR imaging as a tool in patient selection and a follow-up modality. Radiographics 34(4):1099–1119PubMedCrossRef
62.
go back to reference Wakefield JC, Downey K, Kyriazi S, deSouza NM (2013) New MR techniques in gynecologic cancer. AJR Am J Roentgenol 200(2):249–260PubMedCrossRef Wakefield JC, Downey K, Kyriazi S, deSouza NM (2013) New MR techniques in gynecologic cancer. AJR Am J Roentgenol 200(2):249–260PubMedCrossRef
63.
go back to reference Seki H, Azumi R, Kimura M, Sakai K (1997) Stromal invasion by carcinoma of the cervix: assessment with dynamic MR imaging. AJR Am J Roentgenol 168(6):1579–1585PubMedCrossRef Seki H, Azumi R, Kimura M, Sakai K (1997) Stromal invasion by carcinoma of the cervix: assessment with dynamic MR imaging. AJR Am J Roentgenol 168(6):1579–1585PubMedCrossRef
64.
go back to reference Yamashita Y, Takahashi M, Sawada T, Miyazaki K, Okamura H (1992) Carcinoma of the cervix: dynamic MR imaging. Radiology 182(3):643–648PubMedCrossRef Yamashita Y, Takahashi M, Sawada T, Miyazaki K, Okamura H (1992) Carcinoma of the cervix: dynamic MR imaging. Radiology 182(3):643–648PubMedCrossRef
65.
go back to reference Sahdev A, Sohaib SA, Wenaden AE, Shepherd JH, Reznek RH (2007) The performance of magnetic resonance imaging in early cervical carcinoma: a long-term experience. Int J Gynecol Cancer 17(3):629–636PubMedCrossRef Sahdev A, Sohaib SA, Wenaden AE, Shepherd JH, Reznek RH (2007) The performance of magnetic resonance imaging in early cervical carcinoma: a long-term experience. Int J Gynecol Cancer 17(3):629–636PubMedCrossRef
66.
go back to reference Hricak H, Yu KK (1996) Radiology in invasive cervical cancer. AJR Am J Roentgenol 167(5):1101–1108PubMedCrossRef Hricak H, Yu KK (1996) Radiology in invasive cervical cancer. AJR Am J Roentgenol 167(5):1101–1108PubMedCrossRef
67.
go back to reference Hricak H, Lacey CG, Sandles LG, et al. (1988) Invasive cervical carcinoma: comparison of MR imaging and surgical findings. Radiology 166(3):623–631PubMedCrossRef Hricak H, Lacey CG, Sandles LG, et al. (1988) Invasive cervical carcinoma: comparison of MR imaging and surgical findings. Radiology 166(3):623–631PubMedCrossRef
68.
go back to reference Exner M, Kuhn A, Stumpp P, et al. (2016) Value of diffusion-weighted MRI in diagnosis of uterine cervical cancer: a prospective study evaluating the benefits of DWI compared to conventional MR sequences in a 3T environment. Acta Radiol 57(7):869–877PubMedCrossRef Exner M, Kuhn A, Stumpp P, et al. (2016) Value of diffusion-weighted MRI in diagnosis of uterine cervical cancer: a prospective study evaluating the benefits of DWI compared to conventional MR sequences in a 3T environment. Acta Radiol 57(7):869–877PubMedCrossRef
69.
go back to reference Lakhman Y, Akin O, Park KJ, et al. (2013) Stage IB1 cervical cancer: role of preoperative MR imaging in selection of patients for fertility-sparing radical trachelectomy. Radiology 269(1):149–158PubMedCrossRef Lakhman Y, Akin O, Park KJ, et al. (2013) Stage IB1 cervical cancer: role of preoperative MR imaging in selection of patients for fertility-sparing radical trachelectomy. Radiology 269(1):149–158PubMedCrossRef
70.
go back to reference Peppercorn PD, Jeyarajah AR, Woolas R, et al. (1999) Role of MR imaging in the selection of patients with early cervical carcinoma for fertility-preserving surgery: initial experience. Radiology 212(2):395–399PubMedCrossRef Peppercorn PD, Jeyarajah AR, Woolas R, et al. (1999) Role of MR imaging in the selection of patients with early cervical carcinoma for fertility-preserving surgery: initial experience. Radiology 212(2):395–399PubMedCrossRef
71.
go back to reference de Boer P, Adam JA, Buist MR, et al. (2013) Role of MRI in detecting involvement of the uterine internal os in uterine cervical cancer: systematic review of diagnostic test accuracy. Eur J Radiol 82(9):e422–e428PubMedCrossRef de Boer P, Adam JA, Buist MR, et al. (2013) Role of MRI in detecting involvement of the uterine internal os in uterine cervical cancer: systematic review of diagnostic test accuracy. Eur J Radiol 82(9):e422–e428PubMedCrossRef
72.
go back to reference Sonoda Y, Abu-Rustum NR, Gemignani ML, et al. (2004) A fertility-sparing alternative to radical hysterectomy: how many patients may be eligible? Gynecol Oncol 95(3):534–538PubMedCrossRef Sonoda Y, Abu-Rustum NR, Gemignani ML, et al. (2004) A fertility-sparing alternative to radical hysterectomy: how many patients may be eligible? Gynecol Oncol 95(3):534–538PubMedCrossRef
73.
go back to reference Delgado G, Bundy B, Zaino R, et al. (1990) Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 38(3):352–357PubMedCrossRef Delgado G, Bundy B, Zaino R, et al. (1990) Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 38(3):352–357PubMedCrossRef
74.
go back to reference Sedlis A, Bundy BN, Rotman MZ, et al. (1999) A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a Gynecologic Oncology Group Study. Gynecol Oncol 73(2):177–183PubMedCrossRef Sedlis A, Bundy BN, Rotman MZ, et al. (1999) A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a Gynecologic Oncology Group Study. Gynecol Oncol 73(2):177–183PubMedCrossRef
75.
go back to reference Hricak H, Yu KK, Powell CB, et al. (1996) Comparison of diagnostic studies in the pretreatment evaluation of stage Ib carcinoma of the cervix. Acad Radiol 3(Suppl 1):S44–S46PubMedCrossRef Hricak H, Yu KK, Powell CB, et al. (1996) Comparison of diagnostic studies in the pretreatment evaluation of stage Ib carcinoma of the cervix. Acad Radiol 3(Suppl 1):S44–S46PubMedCrossRef
76.
go back to reference Aoki Y, Sasaki M, Watanabe M, et al. (2000) High-risk group in node-positive patients with stage IB, IIA, and IIB cervical carcinoma after radical hysterectomy and postoperative pelvic irradiation. Gynecol Oncol 77(2):305–309PubMedCrossRef Aoki Y, Sasaki M, Watanabe M, et al. (2000) High-risk group in node-positive patients with stage IB, IIA, and IIB cervical carcinoma after radical hysterectomy and postoperative pelvic irradiation. Gynecol Oncol 77(2):305–309PubMedCrossRef
77.
go back to reference McMahon CJ, Rofsky NM, Pedrosa I (2010) Lymphatic metastases from pelvic tumors: anatomic classification, characterization, and staging. Radiology 254(1):31–46PubMedCrossRef McMahon CJ, Rofsky NM, Pedrosa I (2010) Lymphatic metastases from pelvic tumors: anatomic classification, characterization, and staging. Radiology 254(1):31–46PubMedCrossRef
78.
go back to reference Rockall AG, Sohaib SA, Harisinghani MG, et al. (2005) Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer. J Clin Oncol 23(12):2813–2821PubMedCrossRef Rockall AG, Sohaib SA, Harisinghani MG, et al. (2005) Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer. J Clin Oncol 23(12):2813–2821PubMedCrossRef
79.
go back to reference Shen G, Zhou H, Jia Z, Deng H (2015) Diagnostic performance of diffusion-weighted MRI for detection of pelvic metastatic lymph nodes in patients with cervical cancer: a systematic review and meta-analysis. Br J Radiol 88(1052):20150063PubMedPubMedCentralCrossRef Shen G, Zhou H, Jia Z, Deng H (2015) Diagnostic performance of diffusion-weighted MRI for detection of pelvic metastatic lymph nodes in patients with cervical cancer: a systematic review and meta-analysis. Br J Radiol 88(1052):20150063PubMedPubMedCentralCrossRef
80.
go back to reference Stecco A, Buemi F, Cassara A, et al. (2016) Comparison of retrospective PET and MRI-DWI (PET/MRI-DWI) image fusion with PET/CT and MRI-DWI in detection of cervical and endometrial cancer lymph node metastases. Radiol Med (Torino) 121(7):537–545CrossRef Stecco A, Buemi F, Cassara A, et al. (2016) Comparison of retrospective PET and MRI-DWI (PET/MRI-DWI) image fusion with PET/CT and MRI-DWI in detection of cervical and endometrial cancer lymph node metastases. Radiol Med (Torino) 121(7):537–545CrossRef
81.
go back to reference Queiroz MA, Kubik-Huch RA, Hauser N, et al. (2015) PET/MRI and PET/CT in advanced gynaecological tumours: initial experience and comparison. Eur Radiol 25(8):2222–2230PubMedCrossRef Queiroz MA, Kubik-Huch RA, Hauser N, et al. (2015) PET/MRI and PET/CT in advanced gynaecological tumours: initial experience and comparison. Eur Radiol 25(8):2222–2230PubMedCrossRef
82.
go back to reference Ferlay J, Soerjomataram I, Dikshit R, et al. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359–E386PubMedCrossRef Ferlay J, Soerjomataram I, Dikshit R, et al. (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359–E386PubMedCrossRef
84.
go back to reference Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E (2016) Endometrial cancer. Lancet 387(10023):1094–1108PubMedCrossRef Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E (2016) Endometrial cancer. Lancet 387(10023):1094–1108PubMedCrossRef
85.
go back to reference Haoula Z, Salman M, Atiomo W (2012) Evaluating the association between endometrial cancer and polycystic ovary syndrome. Hum Reprod (Oxf Engl) 27(5):1327–1331CrossRef Haoula Z, Salman M, Atiomo W (2012) Evaluating the association between endometrial cancer and polycystic ovary syndrome. Hum Reprod (Oxf Engl) 27(5):1327–1331CrossRef
86.
go back to reference Navaratnarajah R, Pillay OC, Hardiman P (2008) Polycystic ovary syndrome and endometrial cancer. Semin Reprod Med 26(1):62–71PubMedCrossRef Navaratnarajah R, Pillay OC, Hardiman P (2008) Polycystic ovary syndrome and endometrial cancer. Semin Reprod Med 26(1):62–71PubMedCrossRef
87.
go back to reference Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E (2016) Endometrial cancer. Lancet 387(10023):1094–1108PubMedCrossRef Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E (2016) Endometrial cancer. Lancet 387(10023):1094–1108PubMedCrossRef
89.
go back to reference Colombo N, Creutzberg C, Amant F, et al. (2016) ESMO-ESGO-ESTRO Consensus conference on endometrial cancer: diagnosis, treatment and follow-up. Int J Gynecol Cancer 26(1):2–30PubMedCrossRef Colombo N, Creutzberg C, Amant F, et al. (2016) ESMO-ESGO-ESTRO Consensus conference on endometrial cancer: diagnosis, treatment and follow-up. Int J Gynecol Cancer 26(1):2–30PubMedCrossRef
90.
go back to reference Kinkel K, Kaji Y, Yu KK, et al. (1999) Radiologic staging in patients with endometrial cancer: a meta-analysis. Radiology 212(3):711–718PubMedCrossRef Kinkel K, Kaji Y, Yu KK, et al. (1999) Radiologic staging in patients with endometrial cancer: a meta-analysis. Radiology 212(3):711–718PubMedCrossRef
91.
go back to reference Rodolakis A, Biliatis I, Morice P, et al. (2015) European Society of Gynecological Oncology Task Force for Fertility Preservation: clinical recommendations for fertility-sparing management in young endometrial cancer patients. Int J Gynecol Cancer 25(7):1258–1265PubMedCrossRef Rodolakis A, Biliatis I, Morice P, et al. (2015) European Society of Gynecological Oncology Task Force for Fertility Preservation: clinical recommendations for fertility-sparing management in young endometrial cancer patients. Int J Gynecol Cancer 25(7):1258–1265PubMedCrossRef
92.
go back to reference Minig L, Franchi D, Boveri S, et al. (2011) Progestin intrauterine device and GnRH analogue for uterus-sparing treatment of endometrial precancers and well-differentiated early endometrial carcinoma in young women. Ann Oncol 22(3):643–649PubMedCrossRef Minig L, Franchi D, Boveri S, et al. (2011) Progestin intrauterine device and GnRH analogue for uterus-sparing treatment of endometrial precancers and well-differentiated early endometrial carcinoma in young women. Ann Oncol 22(3):643–649PubMedCrossRef
93.
go back to reference Kim MK, Seong SJ, Song T, et al. (2013) Comparison of dilatation & curettage and endometrial aspiration biopsy accuracy in patients treated with high-dose oral progestin plus levonorgestrel intrauterine system for early-stage endometrial cancer. Gynecol Oncol 130(3):470–473PubMedCrossRef Kim MK, Seong SJ, Song T, et al. (2013) Comparison of dilatation & curettage and endometrial aspiration biopsy accuracy in patients treated with high-dose oral progestin plus levonorgestrel intrauterine system for early-stage endometrial cancer. Gynecol Oncol 130(3):470–473PubMedCrossRef
94.
go back to reference Gallos ID, Yap J, Rajkhowa M, et al. (2012) Regression, relapse, and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and metaanalysis. Am J Obstet Gynecol. 207(4):266.e1–266.e12CrossRef Gallos ID, Yap J, Rajkhowa M, et al. (2012) Regression, relapse, and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and metaanalysis. Am J Obstet Gynecol. 207(4):266.e1–266.e12CrossRef
95.
go back to reference Park JY, Kim DY, Kim JH, et al. (2013) Long-term oncologic outcomes after fertility-sparing management using oral progestin for young women with endometrial cancer (KGOG 2002). Eur J Cancer (Oxf Engl). 49(4):868–874CrossRef Park JY, Kim DY, Kim JH, et al. (2013) Long-term oncologic outcomes after fertility-sparing management using oral progestin for young women with endometrial cancer (KGOG 2002). Eur J Cancer (Oxf Engl). 49(4):868–874CrossRef
96.
go back to reference Tangjitgamol S, Manusirivithaya S, Hanprasertpong J (2009) Fertility-sparing in endometrial cancer. Gynecol Obstet Invest 67(4):250–268PubMedCrossRef Tangjitgamol S, Manusirivithaya S, Hanprasertpong J (2009) Fertility-sparing in endometrial cancer. Gynecol Obstet Invest 67(4):250–268PubMedCrossRef
97.
go back to reference Erkanli S, Ayhan A (2010) Fertility-sparing therapy in young women with endometrial cancer: 2010 update. Int J Gynecol Cancer 20(7):1170–1187PubMedCrossRef Erkanli S, Ayhan A (2010) Fertility-sparing therapy in young women with endometrial cancer: 2010 update. Int J Gynecol Cancer 20(7):1170–1187PubMedCrossRef
98.
go back to reference Leitao MM Jr, Kehoe S, Barakat RR, et al. (2009) Comparison of D&C and office endometrial biopsy accuracy in patients with FIGO grade 1 endometrial adenocarcinoma. Gynecol Oncol 113(1):105–108PubMedCrossRef Leitao MM Jr, Kehoe S, Barakat RR, et al. (2009) Comparison of D&C and office endometrial biopsy accuracy in patients with FIGO grade 1 endometrial adenocarcinoma. Gynecol Oncol 113(1):105–108PubMedCrossRef
99.
go back to reference Beddy P, O’Neill AC, Yamamoto AK, et al. (2012) FIGO staging system for endometrial cancer: added benefits of MR imaging. Radiographics 32(1):241–254PubMedCrossRef Beddy P, O’Neill AC, Yamamoto AK, et al. (2012) FIGO staging system for endometrial cancer: added benefits of MR imaging. Radiographics 32(1):241–254PubMedCrossRef
100.
go back to reference Manfredi R, Mirk P, Maresca G, et al. (2004) Local-regional staging of endometrial carcinoma: role of MR imaging in surgical planning. Radiology 231(2):372–378PubMedCrossRef Manfredi R, Mirk P, Maresca G, et al. (2004) Local-regional staging of endometrial carcinoma: role of MR imaging in surgical planning. Radiology 231(2):372–378PubMedCrossRef
101.
go back to reference Yamashita Y, Harada M, Sawada T, et al. (1993) Normal uterus and FIGO stage I endometrial carcinoma: dynamic gadolinium-enhanced MR imaging. Radiology 186(2):495–501PubMedCrossRef Yamashita Y, Harada M, Sawada T, et al. (1993) Normal uterus and FIGO stage I endometrial carcinoma: dynamic gadolinium-enhanced MR imaging. Radiology 186(2):495–501PubMedCrossRef
102.
go back to reference Park SB, Moon MH, Sung CK, Oh S, Lee YH (2014) Dynamic contrast-enhanced MR imaging of endometrial cancer: optimizing the imaging delay for tumour-myometrium contrast. Eur Radiol 24(11):2795–2799PubMedCrossRef Park SB, Moon MH, Sung CK, Oh S, Lee YH (2014) Dynamic contrast-enhanced MR imaging of endometrial cancer: optimizing the imaging delay for tumour-myometrium contrast. Eur Radiol 24(11):2795–2799PubMedCrossRef
103.
go back to reference Tamai K, Koyama T, Saga T, et al. (2007) Diffusion-weighted MR imaging of uterine endometrial cancer. J Magn Reson Imaging 26(3):682–687PubMedCrossRef Tamai K, Koyama T, Saga T, et al. (2007) Diffusion-weighted MR imaging of uterine endometrial cancer. J Magn Reson Imaging 26(3):682–687PubMedCrossRef
104.
go back to reference Fujii S, Matsusue E, Kigawa J, et al. (2008) Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol 18(2):384–389PubMedCrossRef Fujii S, Matsusue E, Kigawa J, et al. (2008) Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol 18(2):384–389PubMedCrossRef
105.
go back to reference Lin G, Ng KK, Chang CJ, et al. (2009) Myometrial invasion in endometrial cancer: diagnostic accuracy of diffusion-weighted 3.0-T MR imaging–initial experience. Radiology 250(3):784–792PubMedCrossRef Lin G, Ng KK, Chang CJ, et al. (2009) Myometrial invasion in endometrial cancer: diagnostic accuracy of diffusion-weighted 3.0-T MR imaging–initial experience. Radiology 250(3):784–792PubMedCrossRef
106.
go back to reference Shen SH, Chiou YY, Wang JH, et al. (2008) Diffusion-weighted single-shot echo-planar imaging with parallel technique in assessment of endometrial cancer. AJR Am J Roentgenol 190(2):481–488PubMedCrossRef Shen SH, Chiou YY, Wang JH, et al. (2008) Diffusion-weighted single-shot echo-planar imaging with parallel technique in assessment of endometrial cancer. AJR Am J Roentgenol 190(2):481–488PubMedCrossRef
107.
go back to reference Fujii S, Kido A, Baba T, et al. (2015) Subendometrial enhancement and peritumoral enhancement for assessing endometrial cancer on dynamic contrast enhanced MR imaging. Eur J Radiol 84(4):581–589PubMedCrossRef Fujii S, Kido A, Baba T, et al. (2015) Subendometrial enhancement and peritumoral enhancement for assessing endometrial cancer on dynamic contrast enhanced MR imaging. Eur J Radiol 84(4):581–589PubMedCrossRef
108.
go back to reference Beddy P, Moyle P, Kataoka M, et al. (2012) Evaluation of depth of myometrial invasion and overall staging in endometrial cancer: comparison of diffusion-weighted and dynamic contrast-enhanced MR imaging. Radiology 262(2):530–537PubMedCrossRef Beddy P, Moyle P, Kataoka M, et al. (2012) Evaluation of depth of myometrial invasion and overall staging in endometrial cancer: comparison of diffusion-weighted and dynamic contrast-enhanced MR imaging. Radiology 262(2):530–537PubMedCrossRef
109.
go back to reference Rechichi G, Galimberti S, Signorelli M, et al. (2011) Endometrial cancer: correlation of apparent diffusion coefficient with tumor grade, depth of myometrial invasion, and presence of lymph node metastases. AJR Am J Roentgenol 197(1):256–262PubMedCrossRef Rechichi G, Galimberti S, Signorelli M, et al. (2011) Endometrial cancer: correlation of apparent diffusion coefficient with tumor grade, depth of myometrial invasion, and presence of lymph node metastases. AJR Am J Roentgenol 197(1):256–262PubMedCrossRef
110.
go back to reference Utsunomiya D, Notsute S, Hayashida Y, et al. (2004) Endometrial carcinoma in adenomyosis: assessment of myometrial invasion on T2-weighted spin-echo and gadolinium-enhanced T1-weighted images. AJR Am J Roentgenol 182(2):399–404PubMedCrossRef Utsunomiya D, Notsute S, Hayashida Y, et al. (2004) Endometrial carcinoma in adenomyosis: assessment of myometrial invasion on T2-weighted spin-echo and gadolinium-enhanced T1-weighted images. AJR Am J Roentgenol 182(2):399–404PubMedCrossRef
111.
go back to reference Turan T, Hizli D, Yilmaz SS, et al. (2012) What is the impact of cervical invasion on lymph node metastasis in patients with stage IIIC endometrial cancer? Arch Gynecol Obstet 285(4):1119–1124PubMedCrossRef Turan T, Hizli D, Yilmaz SS, et al. (2012) What is the impact of cervical invasion on lymph node metastasis in patients with stage IIIC endometrial cancer? Arch Gynecol Obstet 285(4):1119–1124PubMedCrossRef
112.
go back to reference Tewari KS, Filiaci VL, Spirtos NM, et al. (2012) Association of number of positive nodes and cervical stroma invasion with outcome of advanced endometrial cancer treated with chemotherapy or whole abdominal irradiation: a Gynecologic Oncology Group study. Gynecol Oncol 125(1):87–93PubMedCrossRef Tewari KS, Filiaci VL, Spirtos NM, et al. (2012) Association of number of positive nodes and cervical stroma invasion with outcome of advanced endometrial cancer treated with chemotherapy or whole abdominal irradiation: a Gynecologic Oncology Group study. Gynecol Oncol 125(1):87–93PubMedCrossRef
113.
go back to reference Seki H, Takano T, Sakai K (2000) Value of dynamic MR imaging in assessing endometrial carcinoma involvement of the cervix. AJR Am J Roentgenol 175(1):171–176PubMedCrossRef Seki H, Takano T, Sakai K (2000) Value of dynamic MR imaging in assessing endometrial carcinoma involvement of the cervix. AJR Am J Roentgenol 175(1):171–176PubMedCrossRef
114.
go back to reference Lin G, Huang YT, Chao A, et al. (2016) Endometrial cancer with cervical stromal invasion: diagnostic accuracy of diffusion-weighted and dynamic contrast enhanced MR imaging at 3T. Eur Radiol 27(5):1867–1876PubMedCrossRef Lin G, Huang YT, Chao A, et al. (2016) Endometrial cancer with cervical stromal invasion: diagnostic accuracy of diffusion-weighted and dynamic contrast enhanced MR imaging at 3T. Eur Radiol 27(5):1867–1876PubMedCrossRef
115.
go back to reference Castro IM, Connell PP, Waggoner S, Rotmensch J, Mundt AJ (2000) Synchronous ovarian and endometrial malignancies. Am J Clin Oncol 23(5):521–525PubMedCrossRef Castro IM, Connell PP, Waggoner S, Rotmensch J, Mundt AJ (2000) Synchronous ovarian and endometrial malignancies. Am J Clin Oncol 23(5):521–525PubMedCrossRef
116.
go back to reference Gemer O, Bergman M, Segal S (2004) Ovarian metastasis in women with clinical stage I endometrial carcinoma. Acta Obstet Gynecol Scand 83(2):208–210PubMedCrossRef Gemer O, Bergman M, Segal S (2004) Ovarian metastasis in women with clinical stage I endometrial carcinoma. Acta Obstet Gynecol Scand 83(2):208–210PubMedCrossRef
117.
go back to reference Bese T, Sal V, Kahramanoglu I, et al. (2016) Synchronous primary cancers of the endometrium and ovary with the same histopathologic type versus endometrial cancer With ovarian metastasis: a single institution review of 72 cases. Int J Gynecol Cancer 26(2):394–406PubMedCrossRef Bese T, Sal V, Kahramanoglu I, et al. (2016) Synchronous primary cancers of the endometrium and ovary with the same histopathologic type versus endometrial cancer With ovarian metastasis: a single institution review of 72 cases. Int J Gynecol Cancer 26(2):394–406PubMedCrossRef
118.
go back to reference Walsh C, Holschneider C, Hoang Y, et al. (2005) Coexisting ovarian malignancy in young women with endometrial cancer. Obstet Gynecol 106(4):693–699PubMedCrossRef Walsh C, Holschneider C, Hoang Y, et al. (2005) Coexisting ovarian malignancy in young women with endometrial cancer. Obstet Gynecol 106(4):693–699PubMedCrossRef
119.
go back to reference Anglesio MS, Wang YK, Maassen M, et al. (2016) Synchronous endometrial and ovarian carcinomas: evidence of clonality. J Natl Cancer Inst 108(6):djv428PubMedCrossRef Anglesio MS, Wang YK, Maassen M, et al. (2016) Synchronous endometrial and ovarian carcinomas: evidence of clonality. J Natl Cancer Inst 108(6):djv428PubMedCrossRef
120.
go back to reference Schultheis AM, Ng CK, De Filippo MR, et al. (2016) Massively parallel sequencing-based clonality analysis of synchronous endometrioid endometrial and ovarian carcinomas. J Natl Cancer Inst 108(6):djv427PubMedPubMedCentralCrossRef Schultheis AM, Ng CK, De Filippo MR, et al. (2016) Massively parallel sequencing-based clonality analysis of synchronous endometrioid endometrial and ovarian carcinomas. J Natl Cancer Inst 108(6):djv427PubMedPubMedCentralCrossRef
121.
go back to reference Willmott F, Allouni KA, Rockall A (2012) Radiological manifestations of metastasis to the ovary. J Clin Pathol 65(7):585–590PubMedCrossRef Willmott F, Allouni KA, Rockall A (2012) Radiological manifestations of metastasis to the ovary. J Clin Pathol 65(7):585–590PubMedCrossRef
122.
go back to reference Benedetti Panici P, Basile S, Maneschi F, et al. (2008) Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst 100(23):1707–1716PubMedCrossRef Benedetti Panici P, Basile S, Maneschi F, et al. (2008) Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst 100(23):1707–1716PubMedCrossRef
123.
go back to reference Kitchener H, Swart AM, Qian Q, Amos C, Parmar MK (2009) Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 373(9658):125–136PubMedCrossRef Kitchener H, Swart AM, Qian Q, Amos C, Parmar MK (2009) Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 373(9658):125–136PubMedCrossRef
124.
go back to reference Luomaranta A, Leminen A, Loukovaara M (2015) Magnetic resonance imaging in the assessment of high-risk features of endometrial carcinoma: a meta-analysis. Int J Gynecol Cancer 25(5):837–842PubMedCrossRef Luomaranta A, Leminen A, Loukovaara M (2015) Magnetic resonance imaging in the assessment of high-risk features of endometrial carcinoma: a meta-analysis. Int J Gynecol Cancer 25(5):837–842PubMedCrossRef
125.
go back to reference Howlader N, Noone AM, Krapcho M et al (eds) SEER cancer statistics review, 1975–2013. National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/, based on November 2015 SEER data submission, posted to the SEER web site, April 2016. Accessed 7 November 2016. Howlader N, Noone AM, Krapcho M et al (eds) SEER cancer statistics review, 1975–2013. National Cancer Institute. Bethesda, MD, http://​seer.​cancer.​gov/​csr/​1975_​2013/​, based on November 2015 SEER data submission, posted to the SEER web site, April 2016. Accessed 7 November 2016.
126.
go back to reference Hermans AJ, Kluivers KB, Janssen LM, et al. (2016) Adnexal masses in children, adolescents and women of reproductive age in the Netherlands: a nationwide population-based cohort study. Gynecol Oncol 143(1):93–97PubMedCrossRef Hermans AJ, Kluivers KB, Janssen LM, et al. (2016) Adnexal masses in children, adolescents and women of reproductive age in the Netherlands: a nationwide population-based cohort study. Gynecol Oncol 143(1):93–97PubMedCrossRef
127.
go back to reference Quirk JT, Natarajan N, Mettlin CJ (2005) Age-specific ovarian cancer incidence rate patterns in the United States. Gynecol Oncol 99(1):248–250PubMedCrossRef Quirk JT, Natarajan N, Mettlin CJ (2005) Age-specific ovarian cancer incidence rate patterns in the United States. Gynecol Oncol 99(1):248–250PubMedCrossRef
128.
129.
go back to reference Colombo N, Peiretti M, Garbi A, et al. (2012) Non-epithelial ovarian cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii20–vii26PubMed Colombo N, Peiretti M, Garbi A, et al. (2012) Non-epithelial ovarian cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii20–vii26PubMed
131.
go back to reference Ledermann JA, Raja FA, Fotopoulou C, et al. (2013) Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24(Suppl 6):vi24–vi32PubMedCrossRef Ledermann JA, Raja FA, Fotopoulou C, et al. (2013) Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24(Suppl 6):vi24–vi32PubMedCrossRef
132.
go back to reference Colombo N, Parma G, Zanagnolo V, Insinga A (2007) Management of ovarian stromal cell tumors. J Clin Oncol 25(20):2944–2951PubMedCrossRef Colombo N, Parma G, Zanagnolo V, Insinga A (2007) Management of ovarian stromal cell tumors. J Clin Oncol 25(20):2944–2951PubMedCrossRef
133.
go back to reference Satoh T, Hatae M, Watanabe Y, et al. (2010) Outcomes of fertility-sparing surgery for stage I epithelial ovarian cancer: a proposal for patient selection. J Clin Oncol 28(10):1727–1732PubMedCrossRef Satoh T, Hatae M, Watanabe Y, et al. (2010) Outcomes of fertility-sparing surgery for stage I epithelial ovarian cancer: a proposal for patient selection. J Clin Oncol 28(10):1727–1732PubMedCrossRef
134.
go back to reference Shaaban AM, Rezvani M, Elsayes KM, et al. (2014) Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features. Radiographics 34(3):777–801PubMedCrossRef Shaaban AM, Rezvani M, Elsayes KM, et al. (2014) Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features. Radiographics 34(3):777–801PubMedCrossRef
135.
go back to reference Mangili G, Sigismondi C, Gadducci A, et al. (2011) Outcome and risk factors for recurrence in malignant ovarian germ cell tumors: a MITO-9 retrospective study. Int J Gynecol Cancer 21(8):1414–1421PubMedCrossRef Mangili G, Sigismondi C, Gadducci A, et al. (2011) Outcome and risk factors for recurrence in malignant ovarian germ cell tumors: a MITO-9 retrospective study. Int J Gynecol Cancer 21(8):1414–1421PubMedCrossRef
136.
go back to reference Heo SH, Kim JW, Shin SS, et al. (2014) Review of ovarian tumors in children and adolescents: radiologic-pathologic correlation. Radiographics 34(7):2039–2055PubMedCrossRef Heo SH, Kim JW, Shin SS, et al. (2014) Review of ovarian tumors in children and adolescents: radiologic-pathologic correlation. Radiographics 34(7):2039–2055PubMedCrossRef
137.
go back to reference Brown J, Sood AK, Deavers MT, Milojevic L, Gershenson DM (2009) Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? Gynecol Oncol 113(1):86–90PubMedCrossRef Brown J, Sood AK, Deavers MT, Milojevic L, Gershenson DM (2009) Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? Gynecol Oncol 113(1):86–90PubMedCrossRef
138.
go back to reference Kennedy AW, Hart WR (1996) Ovarian papillary serous tumors of low malignant potential (serous borderline tumors). A long-term follow-up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma. Cancer 78(2):278–286PubMedCrossRef Kennedy AW, Hart WR (1996) Ovarian papillary serous tumors of low malignant potential (serous borderline tumors). A long-term follow-up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma. Cancer 78(2):278–286PubMedCrossRef
139.
go back to reference Morice P, Uzan C, Fauvet R, et al. (2012) Borderline ovarian tumour: pathological diagnostic dilemma and risk factors for invasive or lethal recurrence. Lancet Oncol 13(3):e103–e115PubMedCrossRef Morice P, Uzan C, Fauvet R, et al. (2012) Borderline ovarian tumour: pathological diagnostic dilemma and risk factors for invasive or lethal recurrence. Lancet Oncol 13(3):e103–e115PubMedCrossRef
140.
go back to reference Vasconcelos I, de SousaMendes M (2015) Conservative surgery in ovarian borderline tumours: a meta-analysis with emphasis on recurrence risk. Eur J Cancer (Oxf Engl). 51(5):620–631CrossRef Vasconcelos I, de SousaMendes M (2015) Conservative surgery in ovarian borderline tumours: a meta-analysis with emphasis on recurrence risk. Eur J Cancer (Oxf Engl). 51(5):620–631CrossRef
141.
go back to reference Darai E, Fauvet R, Uzan C, et al. (2013) Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options. Hum Reprod Update 19(2):151–166PubMedCrossRef Darai E, Fauvet R, Uzan C, et al. (2013) Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options. Hum Reprod Update 19(2):151–166PubMedCrossRef
142.
go back to reference Uzan C, Muller E, Kane A, et al. (2014) Prognostic factors for recurrence after conservative treatment in a series of 119 patients with stage I serous borderline tumors of the ovary. Ann Oncol 25(1):166–171PubMedCrossRef Uzan C, Muller E, Kane A, et al. (2014) Prognostic factors for recurrence after conservative treatment in a series of 119 patients with stage I serous borderline tumors of the ovary. Ann Oncol 25(1):166–171PubMedCrossRef
143.
go back to reference Palomba S, Falbo A, Del Negro S, et al. (2010) Ultra-conservative fertility-sparing strategy for bilateral borderline ovarian tumours: an 11-year follow-up. Hum Reprod (Oxf Engl) 25(8):1966–1972CrossRef Palomba S, Falbo A, Del Negro S, et al. (2010) Ultra-conservative fertility-sparing strategy for bilateral borderline ovarian tumours: an 11-year follow-up. Hum Reprod (Oxf Engl) 25(8):1966–1972CrossRef
144.
go back to reference Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S (2011) Mucinous tumor of low malignant potential (“borderline” or “atypical proliferative” tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion. Int J Gynecol Pathol 30(3):218–230PubMedCrossRef Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S (2011) Mucinous tumor of low malignant potential (“borderline” or “atypical proliferative” tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion. Int J Gynecol Pathol 30(3):218–230PubMedCrossRef
145.
go back to reference Kinkel K, Hricak H, Lu Y, Tsuda K, Filly RA (2000) US characterization of ovarian masses: a meta-analysis. Radiology 217(3):803–811PubMedCrossRef Kinkel K, Hricak H, Lu Y, Tsuda K, Filly RA (2000) US characterization of ovarian masses: a meta-analysis. Radiology 217(3):803–811PubMedCrossRef
146.
go back to reference Timmerman D, Ameye L, Fischerova D, et al. (2010) Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group. BMJ 341:c6839PubMedPubMedCentralCrossRef Timmerman D, Ameye L, Fischerova D, et al. (2010) Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group. BMJ 341:c6839PubMedPubMedCentralCrossRef
147.
go back to reference Van Calster B, Timmerman D, Valentin L, et al. (2012) Triaging women with ovarian masses for surgery: observational diagnostic study to compare RCOG guidelines with an International Ovarian Tumour Analysis (IOTA) group protocol. BJOG 119(6):662–671PubMedCrossRef Van Calster B, Timmerman D, Valentin L, et al. (2012) Triaging women with ovarian masses for surgery: observational diagnostic study to compare RCOG guidelines with an International Ovarian Tumour Analysis (IOTA) group protocol. BJOG 119(6):662–671PubMedCrossRef
148.
go back to reference Van Calster B, Van Hoorde K, Froyman W, et al. (2015) Practical guidance for applying the ADNEX model from the IOTA group to discriminate between different subtypes of adnexal tumors. Facts Views Vis Obgyn 7(1):32–41PubMedPubMedCentral Van Calster B, Van Hoorde K, Froyman W, et al. (2015) Practical guidance for applying the ADNEX model from the IOTA group to discriminate between different subtypes of adnexal tumors. Facts Views Vis Obgyn 7(1):32–41PubMedPubMedCentral
149.
go back to reference Sohaib SA, Mills TD, Sahdev A, et al. (2005) The role of magnetic resonance imaging and ultrasound in patients with adnexal masses. Clin Radiol 60(3):340–348PubMedCrossRef Sohaib SA, Mills TD, Sahdev A, et al. (2005) The role of magnetic resonance imaging and ultrasound in patients with adnexal masses. Clin Radiol 60(3):340–348PubMedCrossRef
150.
go back to reference Sohaib SA, Sahdev A, Van Trappen P, Jacobs IJ, Reznek RH (2003) Characterization of adnexal mass lesions on MR imaging. AJR Am J Roentgenol 180(5):1297–1304PubMedCrossRef Sohaib SA, Sahdev A, Van Trappen P, Jacobs IJ, Reznek RH (2003) Characterization of adnexal mass lesions on MR imaging. AJR Am J Roentgenol 180(5):1297–1304PubMedCrossRef
151.
go back to reference Hricak H, Chen M, Coakley FV, et al. (2000) Complex adnexal masses: detection and characterization with MR imaging—multivariate analysis. Radiology 214(1):39–46PubMedCrossRef Hricak H, Chen M, Coakley FV, et al. (2000) Complex adnexal masses: detection and characterization with MR imaging—multivariate analysis. Radiology 214(1):39–46PubMedCrossRef
152.
go back to reference Zhao SH, Qiang JW, Zhang GF, et al. (2014) MRI appearances of ovarian serous borderline tumor: pathological correlation. J Magn Reson Imaging 40(1):151–156PubMedCrossRef Zhao SH, Qiang JW, Zhang GF, et al. (2014) MRI appearances of ovarian serous borderline tumor: pathological correlation. J Magn Reson Imaging 40(1):151–156PubMedCrossRef
153.
go back to reference Zhao SH, Qiang JW, Zhang GF, et al. (2014) Diffusion-weighted MR imaging for differentiating borderline from malignant epithelial tumours of the ovary: pathological correlation. Eur Radiol 24(9):2292–2299PubMedCrossRef Zhao SH, Qiang JW, Zhang GF, et al. (2014) Diffusion-weighted MR imaging for differentiating borderline from malignant epithelial tumours of the ovary: pathological correlation. Eur Radiol 24(9):2292–2299PubMedCrossRef
Metadata
Title
Fertility-sparing for young patients with gynecologic cancer: How MRI can guide patient selection prior to conservative management
Authors
Sinead H. McEvoy
Stephanie Nougaret
Nadeem R. Abu-Rustum
Hebert Alberto Vargas
Elizabeth A. Sadowski
Christine O. Menias
Fuki Shitano
Shinya Fujii
Ramon E. Sosa
Joanna G. Escalon
Evis Sala
Yulia Lakhman
Publication date
01-10-2017
Publisher
Springer US
Published in
Abdominal Radiology / Issue 10/2017
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-017-1179-3

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