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European Journal of Nuclear Medicine and Molecular Imaging

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28-05-2022 | Magnetic Resonance Imaging | Review Article

Spatial normalization and quantification approaches of PET imaging for neurological disorders

Authors: Teng Zhang, Shuang Wu, Xiaohui Zhang, Yiwu Dai, Anxin Wang, Hong Zhang, Mei Tian

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 11/2022

Abstract

Quantification approaches of positron emission tomography (PET) imaging provide user-independent evaluation of pathophysiological processes in living brains, which have been strongly recommended in clinical diagnosis of neurological disorders. Most PET quantification approaches depend on spatial normalization of PET images to brain template; however, the spatial normalization and quantification approaches have not been comprehensively reviewed. In this review, we introduced and compared PET template-based and magnetic resonance imaging (MRI)-aided spatial normalization approaches. Tracer-specific and age-specific PET brain templates were surveyed between 1999 and 2021 for ¹⁸F-FDG, ¹¹C-PIB, ¹⁸F-Florbetapir, ¹⁸F-THK5317, and etc., as well as adaptive PET template methods. Spatial normalization-based PET quantification approaches were reviewed, including region-of-interest (ROI)-based and voxel-wise quantitative methods. Spatial normalization-based ROI segmentation approaches were introduced, including manual delineation on template, atlas-based segmentation, and multi-atlas approach. Voxel-wise quantification approaches were reviewed, including voxel-wise statistics and principal component analysis. Certain concerns and representative examples of clinical applications were provided for both ROI-based and voxel-wise quantification approaches. At last, a recipe for PET spatial normalization and quantification approaches was concluded to improve diagnosis accuracy of neurological disorders in clinical practice.

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Title: Spatial normalization and quantification approaches of PET imaging for neurological disorders
Authors: Teng Zhang
Shuang Wu
Xiaohui Zhang
Yiwu Dai
Anxin Wang
Hong Zhang
Mei Tian
Publication date: 28-05-2022
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Alzheimer's Disease
Positron Emission Tomography
Alzheimer's Disease
Mild Cognitive Impairment
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 11/2022
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-022-05809-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Spatial normalization and quantification approaches of PET imaging for neurological disorders

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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