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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 24-02-2022 | Magnetic Resonance Imaging | Original Article

Processing speed dysfunction is associated with functional corticostriatal circuit alterations in childhood epilepsy with centrotemporal spikes: a PET and fMRI study

Authors: Yuting Li, Teng Zhang, Jianhua Feng, Shufang Qian, Shuang Wu, Rui Zhou, Jing Wang, Guo Sa, Xiawan Wang, Lina Li, Feng Chen, Hong Yang, Hong Zhang, Mei Tian

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 9/2022

Abstract

Purpose

Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children and usually presents with cognitive dysfunctions. However, little is known about the processing speed dysfunction and the associated neuroimaging mechanism in ECTS. This study aims to investigate the brain functional abnormality of processing speed dysfunction in ECTS patients by using the ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI).

Methods

This prospective study recruited twenty-eight ECTS patients who underwent the ¹⁸F-FDG PET, rs-fMRI, and neuropsychological examinations. Twenty children with extracranial tumors were included as PET controls, and 20 healthy children were recruited as MRI controls. The PET image analysis investigated glucose metabolism by determining standardized uptake value ratio (SUVR). The MRI image analysis explored abnormal functional connectivity (FC) within the cortical–striatal circuit through network-based statistical (NBS) analysis. Correlation analysis was performed to explore the relationship between SUVR, FC, and processing speed index (PSI).

Results

Compared with healthy controls, ECTS patients showed normal intelligence quotient but significantly decreased PSI (P = 0.04). PET analysis showed significantly decreased SUVRs within bilateral caudate, putamen, pallidum, left NAc, right rostral middle frontal gyrus, and frontal pole of ECTS patients (P < 0.05). Rs-fMRI analysis showed absolute values of 20 FCs were significantly decreased in ECTS patients compared with MRI controls, which connected 16 distinct ROIs. The average SUVR of right caudate and the average of 20 FCs were positively correlated with PSI in ECTS patients (P = 0.034 and P = 0.005, respectively).

Conclusion

This study indicated that ECTS patients presented significantly reduced PSI, which is closely associated with decreased SUVR and FC of cortical–striatal circuit. Caudate played an important role in processing speed dysfunction.

Clinical trial registration

NCT04954729; registered on July 8, 2021, public site, https://clinicaltrials.gov/ct2/show/NCT04954729

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Title: Processing speed dysfunction is associated with functional corticostriatal circuit alterations in childhood epilepsy with centrotemporal spikes: a PET and fMRI study
Authors: Yuting Li
Teng Zhang
Jianhua Feng
Shufang Qian
Shuang Wu
Rui Zhou
Jing Wang
Guo Sa
Xiawan Wang
Lina Li
Feng Chen
Hong Yang
Hong Zhang
Mei Tian
Publication date: 24-02-2022
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Epilepsy
Positron Emission Tomography
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 9/2022
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-022-05740-w

ACC 2024 Congress

Springer Medicine

Processing speed dysfunction is associated with functional corticostriatal circuit alterations in childhood epilepsy with centrotemporal spikes: a PET and fMRI study

Abstract

Purpose

Methods

Results

Conclusion

Clinical trial registration

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Clinical trial registration

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