Published in:
23-12-2021 | Hepatocellular Carcinoma | Original Article
A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization
Authors:
Yang Zhang, Hongwei Cheng, Hu Chen, Peiyao Xu, En Ren, Yonghe Jiang, Dengfeng Li, Xing Gao, Yating Zheng, Pan He, Huirong Lin, Biaoqi Chen, Gan Lin, Aizheng Chen, Chengchao Chu, Jingsong Mao, Gang Liu
Published in:
European Journal of Nuclear Medicine and Molecular Imaging
|
Issue 8/2022
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Abstract
Purpose
To surmount the critical issues of indocyanine green (ICG), and thus achieving a precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization.
Methods
In this study, a facile and green pure-nanomedicine formulation technology is developed to construct carrier-free indocyanine green nanoparticles (nanoICG), and which subsequently dispersed into lipiodol via a super-stable homogeneous lipiodol formulation technology (SHIFT nanoICG) for transcatheter arterial embolization combined near-infrared fluorescence-guided precise hepatectomy.
Results
SHIFT nanoICG integrates excellent anti-photobleaching capacity, great optical imaging property, and specific tumoral deposition to recognize tumor regions, featuring entire-process enduring fluorescent-guided precise hepatectomy, especially in resection of the indiscoverable satellite lesions (0.6 mm × 0.4 mm) in rabbit bearing VX2 orthotopic hepatocellular carcinoma models.
Conclusion
Such a simple and effective strategy provides a promising avenue to address the clinical issue of clinical hepatectomy and has excellent potential for a translational pipeline.