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European Journal of Nuclear Medicine and Molecular Imaging

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01-11-2021 | Editorial

First clinical experience of 106 cm, long axial field-of-view (LAFOV) PET/CT: an elegant balance between standard axial (23 cm) and total-body (194 cm) systems

Authors: Xiaoli Lan, Muhsin H. Younis, Ke Li, Weibo Cai

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2021

Excerpt

Conventional PET/CT scanners with standard axial field-of-view (SAFOV) usually cover around 23–26 cm [1, 2]. Over the last decade, however, there has been tremendous effort in the development of long axial field-of-view (LAFOV) PET/CT scanners, and several of them have entered the clinical arena [3‐5]. It is well recognized that, with LAFOV PET/CT scanners, one could image better (e.g. reconstruct at higher resolution and detect smaller lesions), image faster, image longer after tracer injection, and image gently (e.g., at a much lower radiopharmaceutical dose than usual, which will enable more PET scans in the children population, as well as more repeated scans in the adult population) [1]. …

Cherry SR, Badawi RD, Karp JS, Moses WW, Price P, Jones T. Total-body imaging: transforming the role of positron emission tomography. Sci Transl Med. 2017;9:eaaf6169. https://doi.org/10.1126/scitranslmed.aaf6169.CrossRefPubMedPubMedCentral

Cherry SR, Jones T, Karp JS, Qi J, Moses WW, Badawi RD. Total-body PET: maximizing sensitivity to create new opportunities for clinical research and patient care. J Nucl Med. 2018;59:3–12. https://doi.org/10.2967/jnumed.116.184028.CrossRefPubMedPubMedCentral

Vandenberghe S, Moskal P, Karp JS. State of the art in total body PET. EJNMMI Phys. 2020;7:35. https://doi.org/10.1186/s40658-020-00290-2.CrossRefPubMedPubMedCentral

Badawi RD, Shi H, Hu P, Chen S, Xu T, Price PM, et al. First human imaging studies with the EXPLORER total-body PET scanner. J Nucl Med. 2019;60:299–303. https://doi.org/10.2967/jnumed.119.226498.CrossRefPubMedPubMedCentral

Alberts I, Hünermund JN, Prenosil G, Mingels C, Bohn KP, Viscione M, et al. Clinical performance of long axial field of view PET/CT: a head-to-head intra-individual comparison of the biograph vision quadra with the biograph vision PET/CT. Eur J Nucl Med Mol Imaging. 2021;48:2395–404. https://doi.org/10.1007/s00259-021-05282-7.CrossRefPubMedPubMedCentral

Casey ME, Osborne DR. Siemens Biograph Vision 600. In: Zhang J, Knopp MV, editors. Advances in PET: the latest in instrumentation, technology, and clinical practice. Chambridge: Springer International Publishing; 2020. p. 71–91.CrossRef

Zhang X, Zhou J, Cherry SR, Badawi RD, Qi J. Quantitative image reconstruction for total-body PET imaging using the 2-meter long EXPLORER scanner. Phys Med Biol. 2017;62:2465–85. https://doi.org/10.1088/1361-6560/aa5e46.CrossRefPubMedPubMedCentral

Spencer BA, Berg E, Schmall JP, Omidvari N, Leung EK, Abdelhafez YG, et al. Performance evaluation of the uEXPLORER total-body PET/CT scanner based on NEMA NU 2–2018 with additional tests to characterize long axial field-of-view PET scanners. J Nucl Med. 2021;62:861–70. https://doi.org/10.2967/jnumed.120.250597.CrossRefPubMed

Feng T, Zhao Y, Shi H, Zhang X, Wang G, Badawi RD, et al. Total-body quantitative parametric imaging of early kinetics of FDG. J Nucl Med. 2021;62:738–44. https://doi.org/10.2967/jnumed.119.238113.CrossRefPubMed

10.

Sui X, Liu G, Hu P, Chen S, Yu H, Wang Y, et al. Total-body PET/computed tomography highlights in clinical practice: experiences from Zhongshan Hospital Fudan University. PET Clin. 2021;16:9–14. https://doi.org/10.1016/j.cpet.2020.09.007.CrossRefPubMed

11.

Tan H, Gu Y, Yu H, Hu P, Zhang Y, Mao W, et al. Total-body PET/CT: current applications and future perspectives. AJR Am J Roentgenol. 2020;215:325–37. https://doi.org/10.2214/ajr.19.22705.CrossRefPubMed

12.

Zhang X, Cherry SR, Xie Z, Shi H, Badawi RD, Qi J. Subsecond total-body imaging using ultrasensitive positron emission tomography. Proc Natl Acad Sci USA. 2020;117:2265–7. https://doi.org/10.1073/pnas.1917379117.CrossRefPubMedPubMedCentral

13.

Zhang X, Xie Z, Berg E, Judenhofer MS, Liu W, Xu T, et al. Total-body dynamic reconstruction and parametric imaging on the uEXPLORER. J Nucl Med. 2020;61:285–91. https://doi.org/10.2967/jnumed.119.230565.CrossRefPubMed

14.

Zhang YQ, Hu PC, Wu RZ, Gu YS, Chen SG, Yu HJ, et al. The image quality, lesion detectability, and acquisition time of (18)F-FDG total-body PET/CT in oncological patients. Eur J Nucl Med Mol Imaging. 2020;47:2507–15. https://doi.org/10.1007/s00259-020-04823-w.CrossRefPubMed

15.

Nardo L, Abdelhafez YG, Spencer BA, Badawi RD. Clinical Implementation of total-body PET/CT at University of California. Davis PET Clin. 2021;16:1–7. https://doi.org/10.1016/j.cpet.2020.09.006.CrossRefPubMed

16.

Zhao YM, Li YH, Chen T, Zhang WG, Wang LH, Feng J, et al. Image quality and lesion detectability in low-dose pediatric (18)F-FDG scans using total-body PET/CT. Eur J Nucl Med Mol Imaging. 2021. https://doi.org/10.1007/s00259-021-05304-4.CrossRefPubMed

17.

Hu P, Lin X, Zhuo W, Tan H, Xie T, Liu G, et al. Internal dosimetry in F-18 FDG PET examinations based on long-time-measured organ activities using total-body PET/CT: does it make any difference from a short-time measurement? EJNMMI Phys. 2021;8:51. https://doi.org/10.1186/s40658-021-00395-2.CrossRefPubMed

18.

Spencer BA, Berg E, Schmall JP, Omidvari N, Leung EK, Abdelhafez YG, et al. Performance evaluation of the uEXPLORER total-body PET/CT scanner based on NEMA NU 2–2018 with additional tests to characterize PET scanners with a long axial field of view. J Nucl Med. 2021;62:861–70. https://doi.org/10.2967/jnumed.120.250597.CrossRefPubMed

19.

Hu P, Zhang Y, Yu H, Chen S, Tan H, Qi C, et al. Total-body (18)F-FDG PET/CT scan in oncology patients: how fast could it be? Eur J Nucl Med Mol Imaging. 2021;48:2384–94. https://doi.org/10.1007/s00259-021-05357-5.CrossRefPubMed

20.

Tan H, Sui X, Yin H, Yu H, Gu Y, Chen S, et al. Total-body PET/CT using half-dose FDG and compared with conventional PET/CT using full-dose FDG in lung cancer. Eur J Nucl Med Mol Imaging. 2021;48:1966–75. https://doi.org/10.1007/s00259-020-05091-4.CrossRefPubMed

21.

Martí-Climent JM, Prieto E, Morán V, Sancho L, Rodríguez-Fraile M, Arbizu J, et al. Effective dose estimation for oncological and neurological PET/CT procedures. EJNMMI Res. 2017;7:37. https://doi.org/10.1186/s13550-017-0272-5.CrossRefPubMedPubMedCentral

22.

Hemke R, Yang K, Husseini J, Bredella MA, Simeone FJ. Organ dose and total effective dose of whole-body CT in multiple myeloma patients. Skeletal Radiol. 2020;49:549–54. https://doi.org/10.1007/s00256-019-03292-z.CrossRefPubMed

23.

McCollough CH, Bushberg JT, Fletcher JG, Eckel LJ. Answers to common questions about the use and safety of CT scans. Mayo Clin Proc. 2015;90:1380–92. https://doi.org/10.1016/j.mayocp.2015.07.011.CrossRefPubMed

24.

McCollough CH, Chen GH, Kalender W, Leng S, Samei E, Taguchi K, et al. Achieving routine submillisievert CT scanning: report from the summit on management of radiation dose in CT. Radiology. 2012;264:567–80. https://doi.org/10.1148/radiol.12112265.CrossRefPubMedPubMedCentral

25.

Greffier J, Hamard A, Pereira F, Barrau C, Pasquier H, Beregi JP, et al. Image quality and dose reduction opportunity of deep learning image reconstruction algorithm for CT: a phantom study. Eur Radiol. 2020;30:3951–9. https://doi.org/10.1007/s00330-020-06724-w.CrossRefPubMed

26.

Park C, Choo KS, Jung Y, Jeong HS, Hwang JY, Yun MS. CT iterative vs deep learning reconstruction: comparison of noise and sharpness. Eur Radiol. 2021;31:3156–64. https://doi.org/10.1007/s00330-020-07358-8.CrossRefPubMed

27.

Naganawa S, Nakamichi R, Ichikawa K, Kawamura M, Kawai H, Yoshida T, et al. MR imaging of endolymphatic hydrops: utility of iHYDROPS-Mi2 combined with deep learning reconstruction denoising. Magn Reson Med Sci. 2020. https://doi.org/10.2463/mrms.mp.2020-0082.CrossRefPubMedPubMedCentral

28.

Singh R, Digumarthy SR, Muse VV, Kambadakone AR, Blake MA, Tabari A, et al. Image quality and lesion detection on deep learning reconstruction and iterative reconstruction of submillisievert chest and abdominal CT. AJR Am J Roentgenol. 2020;214:566–73. https://doi.org/10.2214/ajr.19.21809.CrossRefPubMed

29.

Ueda T, Ohno Y, Yamamoto K, Iwase A, Fukuba T, Hanamatsu S, et al. Compressed sensing and deep learning reconstruction for women’s pelvic MRI denoising: utility for improving image quality and examination time in routine clinical practice. Eur J Radiol. 2020;134: 109430. https://doi.org/10.1016/j.ejrad.2020.109430.CrossRefPubMed

30.

Paul DM, Ghiuzeli CM, Rini J, Palestro CJ, Fung EK, Ghali M, et al. A pilot study treatment of malignant tumors using low-dose (18)F-fluorodeoxyglucose ((18)F-FDG). Am J Nucl Med Mol Imaging. 2020;10:334–41.PubMedPubMedCentral

31.

Borra A, Morbelli S, Zwarthoed C, Bianchi A, Bergesio F, Chauvie S, et al. Dual-point FDG-PET/CT for treatment response assessment in Hodgkin lymphoma, when an FDG-avid lesion persists after treatment. Am J Nucl Med Mol Imaging. 2019;9:176–84.PubMedPubMedCentral

32.

Bois F, Noirot C, Dietemann S, Mainta IC, Zilli T, Garibotto V, et al. [(68)Ga]Ga-PSMA-11 in prostate cancer: a comprehensive review. Am J Nucl Med Mol Imaging. 2020;10:349–74.PubMedPubMedCentral

33.

Asadollahi S, Rojulpote C, Bhattaru A, Patil S, Gonuguntla K, Karambelkar P, et al. Comparison of atherosclerotic burden in non-lower extremity arteries in patients with and without peripheral artery disease using (18)F-NaF-PET/CT imaging. Am J Nucl Med Mol Imaging. 2020;10:272–8.PubMedPubMedCentral

34.

Brandão SCS, Ramos JOX, de Arruda GFA, Godoi E, Carreira L, Lopes RW, et al. Mapping COVID-19 functional sequelae: the perspective of nuclear medicine. Am J Nucl Med Mol Imaging. 2020;10:319–33.PubMedPubMedCentral

35.

Zadeh MZ, Seraj SM, Østergaard B, Mimms S, Raynor WY, Aly M, et al. Prognostic significance of (18)F-sodium fluoride in newly diagnosed multiple myeloma patients. Am J Nucl Med Mol Imaging. 2020;10:151–60.PubMedPubMedCentral

36.

Zhang V, Borja AJ, Rojulpote C, Padmanabhan S, Patil S, Gonuguntla K, et al. Global quantification of pulmonary artery atherosclerosis using (18)F-sodium fluoride PET/CT in at-risk subjects. Am J Nucl Med Mol Imaging. 2020;10:119–26.PubMedPubMedCentral

37.

Masselli G, De Angelis C, Sollaku S, Casciani E, Gualdi G. PET/CT in pediatric oncology. Am J Nucl Med Mol Imaging. 2020;10:83–94.PubMedPubMedCentral

38.

Alberts I, Prenosil G, Mingels C, Bohn KP, Viscione M, Sari H, et al. Feasibility of late acquisition [68Ga]Ga-PSMA-11 PET/CT using a long axial field-of-view PET/CT scanner for the diagnosis of recurrent prostate cancer-first clinical experiences. Eur J Nucl Med Mol Imaging. 2021. https://doi.org/10.1007/s00259-021-05438-5.CrossRefPubMed

39.

Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM. Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med. 1975;16:210–24.PubMed

40.

Ter-Pogossian MM, Phelps ME, Hoffman EJ, Mullani NA. A positron-emission transaxial tomograph for nuclear imaging (PETT). Radiology. 1975;114:89–98. https://doi.org/10.1148/114.1.89.CrossRefPubMed

41.

Beyer T, Townsend DW, Czernin J, Freudenberg LS. The future of hybrid imaging-part 2: PET/CT. Insights Imaging. 2011;2:225–34. https://doi.org/10.1007/s13244-011-0069-4.CrossRefPubMedPubMedCentral

42.

Townsend D, Beyer T, Czernin J. 20 years of PET/CT: a conversation with David Townsend and Thomas Beyer. J Nucl Med. 2020;61:1541–3. https://doi.org/10.2967/jnumed.120.257725.CrossRefPubMed

43.

Kung BT, Seraj SM, Zadeh MZ, Rojulpote C, Kothekar E, Ayubcha C, et al. An update on the role of (18)F-FDG-PET/CT in major infectious and inflammatory diseases. Am J Nucl Med Mol Imaging. 2019;9:255–73.PubMedPubMedCentral

44.

Wei W, Ehlerding EB, Lan X, Luo QY, Cai W. Molecular imaging of β-cells: diabetes and beyond. Adv Drug Deliv Rev. 2019;139:16–31. https://doi.org/10.1016/j.addr.2018.06.022.CrossRefPubMed

45.

Wei W, Rosenkrans ZT, Liu J, Huang G, Luo QY, Cai W. ImmunoPET: concept, design, and applications. Chem Rev. 2020;120:3787–851. https://doi.org/10.1021/acs.chemrev.9b00738.CrossRefPubMedPubMedCentral

46.

Saboury B, Morris MA, Nikpanah M, Werner TJ, Jones EC, Alavi A. Reinventing molecular imaging with total-body PET, part II: clinical applications. PET Clin. 2020;15:463–75. https://doi.org/10.1016/j.cpet.2020.06.013.CrossRefPubMedPubMedCentral

Title: First clinical experience of 106 cm, long axial field-of-view (LAFOV) PET/CT: an elegant balance between standard axial (23 cm) and total-body (194 cm) systems
Authors: Xiaoli Lan
Muhsin H. Younis
Ke Li
Weibo Cai
Publication date: 01-11-2021
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2021
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05505-x

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