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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 12/2021

01-11-2021 | Lung Cancer | Review Article

Structural and functional radiomics for lung cancer

Authors: Guangyao Wu, Arthur Jochems, Turkey Refaee, Abdalla Ibrahim, Chenggong Yan, Sebastian Sanduleanu, Henry C. Woodruff, Philippe Lambin

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 12/2021

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Abstract

Introduction

Lung cancer ranks second in new cancer cases and first in cancer-related deaths worldwide. Precision medicine is working on altering treatment approaches and improving outcomes in this patient population. Radiological images are a powerful non-invasive tool in the screening and diagnosis of early-stage lung cancer, treatment strategy support, prognosis assessment, and follow-up for advanced-stage lung cancer. Recently, radiological features have evolved from solely semantic to include (handcrafted and deep) radiomic features. Radiomics entails the extraction and analysis of quantitative features from medical images using mathematical and machine learning methods to explore possible ties with biology and clinical outcomes.

Methods

Here, we outline the latest applications of both structural and functional radiomics in detection, diagnosis, and prediction of pathology, gene mutation, treatment strategy, follow-up, treatment response evaluation, and prognosis in the field of lung cancer.

Conclusion

The major drawbacks of radiomics are the lack of large datasets with high-quality data, standardization of methodology, the black-box nature of deep learning, and reproducibility. The prerequisite for the clinical implementation of radiomics is that these limitations are addressed. Future directions include a safer and more efficient model-training mode, merge multi-modality images, and combined multi-discipline or multi-omics to form “Medomics.”
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Metadata
Title
Structural and functional radiomics for lung cancer
Authors
Guangyao Wu
Arthur Jochems
Turkey Refaee
Abdalla Ibrahim
Chenggong Yan
Sebastian Sanduleanu
Henry C. Woodruff
Philippe Lambin
Publication date
01-11-2021
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 12/2021
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-021-05242-1

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