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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-02-2012 | Review Article

¹¹¹In-DTPA⁰-octreotide (Octreoscan), ¹³¹I-MIBG and other agents for radionuclide therapy of NETs

Authors: Jamshed B. Bomanji, Nikolaos D. Papathanasiou

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2012

Abstract

This paper is a critical review of the literature on NET radionuclide therapy with ¹¹¹In-DTPA⁰-octreotide (Octreoscan) and ¹³¹I-MIBG, focusing on efficacy and toxicity. Some potential future applications and new candidate therapeutic agents are also mentioned. Octreoscan has been a pioneering agent for somatostatin receptor radionuclide therapy. It has achieved symptomatic responses and disease stabilization, but it is now outperformed by the corresponding β-emitter agents ¹⁷⁷Lu-DOTATATE and ⁹⁰Y-DOTATOC. ¹³¹I-MIBG is the radionuclide therapy of choice for inoperable or metastatic phaeochromocytomas/paragangliomas, which avidly concentrate this tracer via the noradrenaline transporter. Symptomatic, biochemical and tumour morphological response rates of 50–89%, 45–74% and 27–47%, respectively, have been reported. ¹³¹I-MIBG is a second-line radiopharmaceutical for treatment of enterochromaffin carcinoids, mainly offering the benefit of amelioration of hormone-induced symptoms. High specific activity, non-carrier-added ¹³¹I-MIBG and meta-astato(²¹¹At)-benzylguanidine (MABG) are tracers with potential for enhanced therapeutic efficacy, yet their integration into clinical practice awaits further exploration. Amongst other promising agents, radiolabelled exendin analogues show potential for imaging and possibly therapy of insulinomas, while preclinical studies are currently evaluating DOTA peptides targeting the CCK-2/gastrin receptors that are overexpressed by medullary thyroid carcinoma cells.

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Title: 111In-DTPA0-octreotide (Octreoscan), 131I-MIBG and other agents for radionuclide therapy of NETs
Authors: Jamshed B. Bomanji
Nikolaos D. Papathanasiou
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2012
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-2013-8

At a glance: The STEP trials

Springer Medicine

¹¹¹In-DTPA⁰-octreotide (Octreoscan), ¹³¹I-MIBG and other agents for radionuclide therapy of NETs

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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