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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 01-02-2012 | Review Article

Lutetium-labelled peptides for therapy of neuroendocrine tumours

Authors: B. L. R. Kam, J. J. M. Teunissen, E. P. Krenning, W. W. de Herder, S. Khan, E. I. van Vliet, D. J. Kwekkeboom

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2012

Abstract

Treatment with radiolabelled somatostatin analogues is a promising new tool in the management of patients with inoperable or metastasized neuroendocrine tumours. Symptomatic improvement may occur with ¹⁷⁷Lu-labelled somatostatin analogues that have been used for peptide receptor radionuclide therapy (PRRT). The results obtained with ¹⁷⁷Lu-[DOTA⁰,Tyr³]octreotate (DOTATATE) are very encouraging in terms of tumour regression. Dosimetry studies with ¹⁷⁷Lu-DOTATATE as well as the limited side effects with additional cycles of ¹⁷⁷Lu-DOTATATE suggest that more cycles of ¹⁷⁷Lu-DOTATATE can be safely given. Also, if kidney-protective agents are used, the side effects of this therapy are few and mild and less than those from the use of ⁹⁰Y-[DOTA⁰,Tyr³]octreotide (DOTATOC). Besides objective tumour responses, the median progression-free survival is more than 40 months. The patients' self-assessed quality of life increases significantly after treatment with ¹⁷⁷Lu-DOTATATE. Lastly, compared to historical controls, there is a benefit in overall survival of several years from the time of diagnosis in patients treated with ¹⁷⁷Lu-DOTATATE. These findings compare favourably with the limited number of alternative therapeutic approaches. If more widespread use of PRRT can be guaranteed, such therapy may well become the therapy of first choice in patients with metastasized or inoperable neuroendocrine tumours.

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Title: Lutetium-labelled peptides for therapy of neuroendocrine tumours
Authors: B. L. R. Kam
J. J. M. Teunissen
E. P. Krenning
W. W. de Herder
S. Khan
E. I. van Vliet
D. J. Kwekkeboom
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2012
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-2039-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Lutetium-labelled peptides for therapy of neuroendocrine tumours

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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