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European Journal of Nuclear Medicine and Molecular Imaging

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01-05-2008 | Guidelines

EANM procedure guidelines for ¹³¹I-meta-iodobenzylguanidine (¹³¹I-mIBG) therapy

Authors: Francesco Giammarile, Arturo Chiti, Michael Lassmann, Boudewijn Brans, Glenn Flux

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 5/2008

Abstract

Meta-iodobenzylguanidine, or Iobenguane, is an aralkylguanidine resulting from the combination of the benzyl group of bretylium and the guanidine group of guanethidine (an adrenergic neurone blocker). It is a noradrenaline (norepinephrine) analogue and so-called “false” neurotransmitter. This radiopharmaceutical, labeled with ¹³¹I, could be used as a radiotherapeutic metabolic agent in neuroectodermal tumours, that are derived from the primitive neural crest which develops to form the sympathetic nervous system. The neuroendocrine system is derived from a family of cells originating in the neural crest, characterized by an ability to incorporate amine precursors with subsequent decarboxylation. The purpose of this guideline is to assist nuclear medicine practitioners to evaluate patients who might be candidates for ¹³¹I-meta-iodobenzylguanidine to treat neuro-ectodermal tumours, to provide information for performing this treatment and to understand and evaluate the consequences of therapy.

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Title: EANM procedure guidelines for 131I-meta-iodobenzylguanidine (131I-mIBG) therapy
Authors: Francesco Giammarile
Arturo Chiti
Michael Lassmann
Boudewijn Brans
Glenn Flux
Publication date: 01-05-2008
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 5/2008
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-008-0715-3

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EANM procedure guidelines for ¹³¹I-meta-iodobenzylguanidine (¹³¹I-mIBG) therapy

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