Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Skeletal Radiology
Published in: Skeletal Radiology 6/2007

01-06-2007 | Case Report

Solitary intramuscular myxoma with monostotic fibrous dysplasia as a rare variant of Mazabraud’s syndrome

Authors: Makoto Endo, Akira Kawai, Eisuke Kobayashi, Yuki Morimoto, Umio Yamaguchi, Fumihiko Nakatani, Hirokazu Chuman, Kunihiko Seki, Yasuo Beppu

Published in: Skeletal Radiology | Issue 6/2007

Login to get access

Abstract

The rare coexistence of intramuscular myxoma (IM) and fibrous dysplasia (FD) is known as Mazabraud’s syndrome. IM tends to occur multifocally and is associated most frequently with polyostotic FD in Mazabraud’s syndrome. We present an extremely rare combination of a solitary IM and monostotic FD as a variant of Mazabraud’s syndrome, and discuss the importance of recognizing this rare coexistence for appropriate management of the patient.
Literature
1.
Henschen F. Fall von ostitis Fibrosa mit multiplen Tumoren in der umgebenden Muskulatur. Verh Dtsch Ges Pathol 1926;21:93–7.
2.
Mazabraud A, Semat P, Roze R. A propos de I’association de fibromyxomes des tissus molle a la dysplasie fibreuse des os. Presse Med 1967;75:2223–8.PubMed
3.
Wirth WA, Leavitt D, Enzinger FM. Multiple intramuscular myxomas. Another extraskeletal manifestation of fibrous dysplasia. Cancer 1971;27:1167–73.CrossRef
4.
Segev Z, Reiner S. Intramuscular myxoma associated with fibrous dysplasia of adjacent bone. Harefuah 1985;108:493–4.PubMed
5.
Sundaram M, McDonald DJ, Merenda G. Intramuscular myxoma: a rare but important association with fibrous dysplasia of bone. Am J Roentgenol 1989;153:107–8.CrossRef
6.
Gober GA, Nicholas RW. Case report 800: skeletal fibrous dysplasia associated with intramuscular myxoma (Mazabraud’s syndrome). Skelet Radiol 1993;22:452–5.CrossRef
7.
Prayson MA, Leeson MC. Soft-tissue myxomas and fibrous dysplasia of bone. A case report and review of the literature. Clin Orthop Relat Res 1993;222–8.
8.
Aoki T, Kouho H, Hisaoka M, Hashimoto H, Nakata H, Sakai A. Intramuscular myxoma with fibrous dysplasia: a report of two cases with a review of the literature. Pathol Int 1995;45:165–71.CrossRef
9.
Fujii K, Inoue M, Araki Y, Ishida O. Multiple intramuscular myxomas associated with polyostotic fibrous dysplasia. Eur J Radiol 1996;22:152–4.CrossRef
10.
Court-Payen M, Ingemann Jensen L, Bjerregaard B, Schwarz Lausten G, Skjoldbye B. Intramuscular myxoma and fibrous dysplasia of bone-Mazabraud’s syndrome. A case report. Acta Radiol 1997;38:368–71.PubMed
11.
Szendroi M, Rahoty P, Antal I, Kiss J. Fibrous dysplasia associated with intramuscular myxoma (Mazabraud’s syndrome): a long-term follow-up of three cases. J Cancer Res Clin Oncol 1998;124:401–6.CrossRef
12.
Cabral CE, Guedes P, Fonseca T, Rezende JF, Cruz LC Jr, Smith J. Polyostotic fibrous dysplasia associated with intramuscular myxomas: Mazabraud’s syndrome. Skelet Radiol 1998;27:278–82.CrossRef
13.
Walker RE, Schwartz RK, Gale DR. Musculoskeletal case of the day. Mazabraud’s syndrome (intramuscular myxomas associated with fibrous dysplasia of bone). Am J Roentgenol 1999;173:797, 800–2.CrossRef
14.
Lopez-Ben R, Pitt MJ, Jaffe KA, Siegal GP. Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud’s syndrome. Skelet Radiol 1999;28:522–6.CrossRef
15.
Okamoto S, Hisaoka M, Ushijima M, Nakahara S, Toyoshima S, Hashimoto H. Activating Gs(alpha) mutation in intramuscular myxomas with and without fibrous dysplasia of bone. Virchows Arch 2000;437:133–7.CrossRef
16.
Faivre L, Nivelon-Chevallier A, Kottler ML, Robinet C, Khau Van Kien P, Lorcerie B, Munnich A, Maroteaux P, Cormier-Daire V, LeMerrer M. Mazabraud syndrome in two patients: clinical overlap with McCune-Albright syndrome. Am J Med Genet 2001;99:132–6.CrossRef
17.
Iwasko N, Steinbach LS, Disler D, Pathria M, Hottya GA, Kattapuram S, et al. Imaging findings in Mazabraud’s syndrome: seven new cases. Skelet Radiol 2002;31:81–7.CrossRef
18.
Nguyen BD, Ram PC. Mazabraud’s syndrome with sarcomatous transformation: scintigraphic and radiologic imaging. Clin Nucl Med 2005;30:829–30.CrossRef
19.
Silver WP, Harrelson JM, Scully SP. Intramuscular myxoma: a clinicopathologic study of 17 patients. Clin Orthop Relat Res 2002;191–7.CrossRef
20.
Nielsen G, Stenman G. Intramuscular myxoma. In: Fletcher CDM, Unni KK, Mertens F (eds) World Health Organization classification of tumours pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 186–7.
21.
Siegal G, Cin PD, Araujo ES. Fibrous dysplasia. In: Fletcher CDM, Unni KK, Mertens F (eds) World Health Organization classification of tumours pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 341–2.
22.
Harris WH, Dudley HR, Barry RJ. The natural history of fibrous dysplasia. J Bone Jt Surg Am 1962;44:207–33.CrossRef
23.
Cohen MM Jr. Fibrous dysplasia is a neoplasm. Am J Med Genet 2001;98:290–3.CrossRef
24.
Dal Cin P, Sciot R, Brys P, de Wever I, Dorfman H, Fletchera CD, et al. Recurrent chromosome aberrations in fibrous dysplasia of the bone: a report of the CHAMP study group. CHromosomes And MorPhology. Cancer Genet Cytogenet 2000;122:30–2.CrossRef
25.
Bancroft LW, Kransdorf MJ, Menke DM, O’Connor MI, Foster WC. Intramuscular myxoma: characteristic MR imaging features. Am J Roentgenol 2002;178:1255–9.CrossRef
26.
Jhala DN, Eltoum I, Carroll AJ, Lopez-Ben R, Lopez-Terrada D, Rao PH, et al. Osteosarcoma in a patient with McCune-Albright syndrome and Mazabraud’s syndrome: a case report emphasizing the cytological and cytogenetic findings. Hum Pathol 2003;34:1354–7.CrossRef
Metadata
Title
Solitary intramuscular myxoma with monostotic fibrous dysplasia as a rare variant of Mazabraud’s syndrome
Authors
Makoto Endo
Akira Kawai
Eisuke Kobayashi
Yuki Morimoto
Umio Yamaguchi
Fumihiko Nakatani
Hirokazu Chuman
Kunihiko Seki
Yasuo Beppu
Publication date
01-06-2007
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 6/2007
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-006-0234-x

Other articles of this Issue 6/2007

Skeletal Radiology 6/2007 Go to the issue

Case Report

MRI of rupture of the spring ligament complex with talo-cuboid impaction

Perspective

Nerves in bone: the silent partners

Announcements

Announcements

Browser's Notes

Browser’s Notes

Case Report

Bizarre parosteal osteochondromatous proliferation of the proximal humerus: case report

Abstracts

European Society of Musculoskeletal Radiology (ESSR) - 14th Annual Meeting, 1–2 June 2007, Izmir, Turkey