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01-12-2020 | Thrombosis | Review Article

Evaluating the Longevity of the Fontan Pathway

Authors: John M. Kelly, Gabriel J. M. Mirhaidari, Yu-Chun Chang, Toshiharu Shinoka, Christopher K. Breuer, Andrew R. Yates, Kan N. Hor

Published in: Pediatric Cardiology | Issue 8/2020

Abstract

Children born with single ventricle physiology who undergo Fontan palliation face a diverse set of long-term complications. However, patient follow-up has in large part been limited to single institutional experiences without uniform application of diagnostic modalities to screen for relevant outcomes. Additionally, the use of different graft materials and variable surgical technique as part of the Fontan procedure has further complicated the evaluation of single ventricle patients. The purpose of this review is to define the changes in the Fontan pathway specific to the graft material used and its relationship to patient outcomes. As a means of introduction, we briefly review the historical evolution of the Fontan procedure with a focus on the intent behind design changes and incorporation of different biomaterials. We further delineate changes to the Fontan pathway which include the development of stenosis, differential growth, thrombosis, and calcification. Ultimately, the recognition of the changes noted within the Fontan pathway need to be assessed relative to their impact on patient hemodynamics, functional capacity, and Fontan-associated comorbidities.

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Title: Evaluating the Longevity of the Fontan Pathway
Authors: John M. Kelly
Gabriel J. M. Mirhaidari
Yu-Chun Chang
Toshiharu Shinoka
Christopher K. Breuer
Andrew R. Yates
Kan N. Hor
Publication date: 01-12-2020
Publisher: Springer US
Keyword: Thrombosis
Published in: Pediatric Cardiology / Issue 8/2020
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-020-02452-6

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