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Pediatric Cardiology
Published in: Pediatric Cardiology 7/2013

01-10-2013 | Case Report

Response to a Single Dose of Sildenafil in Single-Ventricle Patients: An Echocardiographic Evaluation

Authors: Kimberly W. Jackson, Ryan J. Butts, Amy J. Svenson, Tim C. McQuinn, Andrew M. Atz

Published in: Pediatric Cardiology | Issue 7/2013

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Abstract

New evidence of increased phosphodiesterase-5 (PDE-5) in hypertrophied human myocardium suggests that sildenafil, a selective PDE-5 inhibitor, may improve muscle contraction and therefore improve ventricular function. The purpose of this study was to compare ventricular function as assessed by echocardiography in 10 surgically palliated single-ventricle patients at baseline and again after a single dose of sildenafil. The velocity time integral of the ventricular outflow tract was increased 2 h after sildenafil administration (p = 0.01), thus suggesting an improvement in cardiac output.
Literature
1.
Botha P, Parry G, Dark JH, Macgowan GA (2009) Acute hemodynamic effects of intravenous sildenafil citrate in congestive heart failure: comparison of phosphodiesterase type-3 and -5 inhibition. J Heart Lung Transplant 28(7):676–682CrossRefPubMed
2.
Giardini A, Balducci A, Specchia S, Gargiulo G, Bonvicini M, Picchio FM (2008) Effect of sildenafil on haemodynamic response to exercise and exercise capacity in Fontan patients. Eur Heart J 29(13):1681–1687CrossRefPubMed
3.
Goldberg DJ, French B, McBride MG, Marino BS, Mirarchi N, Hanna BD et al (2011) Impact of oral sildenafil on exercise performance in children and young adults after the Fontan operation: a randomized, double-blind, placebo-controlled, crossover trial. Circulation 123(11):1185–1193PubMedCentralCrossRefPubMed
4.
Jung SY, Seo YG, Kim GK, Woo JS, Yong CS, Choi HG (2011) Comparison of the solubility and pharmacokinetics of sildenafil salts. Arch Pharm Res 34(3):451–454CrossRefPubMed
5.
Khairy P, Ionescu-Ittu R, Mackie AS, Abrahamowicz M, Pilote L, Marelli AJ (2010) Changing mortality in congenital heart disease. J Am Coll Cardiol 56(14):1149–1157CrossRefPubMed
6.
Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A et al (2007) Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 116(3):238–248CrossRefPubMed
7.
Raja SG, Danton MD, MacArthur KJ, Pollock JC (2006) Treatment of pulmonary arterial hypertension with sildenafil: from pathophysiology to clinical evidence. J Cardiothorac Vasc Anesth 20(5):722–735CrossRefPubMed
8.
Reinhardt Z, Uzun O, Bhole V, Ofoe V, Wilson D, Onuzo O et al (2010) Sildenafil in the management of the failing Fontan circulation. Cardiol Young 20(5):522–525CrossRefPubMed
9.
Sundareswaran KS, Pekkan K, Dasi LP, Whitehead K, Sharma S, Kanter KR et al (2008) The total cavopulmonary connection resistance: a significant impact on single ventricle hemodynamics at rest and exercise. Am J Physiol Heart Circ Physiol 295(6):H2427–H2435PubMedCentralCrossRefPubMed
Metadata
Title
Response to a Single Dose of Sildenafil in Single-Ventricle Patients: An Echocardiographic Evaluation
Authors
Kimberly W. Jackson
Ryan J. Butts
Amy J. Svenson
Tim C. McQuinn
Andrew M. Atz
Publication date
01-10-2013
Publisher
Springer US
Published in
Pediatric Cardiology / Issue 7/2013
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-012-0415-4

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