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Published in: Neuroradiology 9/2021

Open Access 01-09-2021 | Magnetic Resonance Imaging | Short Report

Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging

Authors: Max Scheffler, Rares Salomir, Enrique Maturana, Marie-Louise Montandon, Enikö V. Kövari, Sven Haller

Published in: Neuroradiology | Issue 9/2021

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Abstract

Cortical microinfarcts (CMI) are increasingly recognized in the neurological community as a biomarker related to cognitive impairment and dementia. If their radiological depiction has been largely described in experimental settings using ultra-high-field magnetic resonance imaging (MRI), less is known about their visibility on routinely used 3-T MRI. In this radiologic-pathologic correlation study, using 3-T post-mortem MRI, we searched for hippocampal CMI, in a double-blinded fashion, and found that only 4/36, or 11%, were clearly demonstrated on both radiological and histopathological exams.
Literature
1.
go back to reference Damasceno BP (2012) Relationship between cortical microinfarcts and cognitive impairment in Alzheimer’s disease. Dement Neuropsychol 6(3):131–136CrossRef Damasceno BP (2012) Relationship between cortical microinfarcts and cognitive impairment in Alzheimer’s disease. Dement Neuropsychol 6(3):131–136CrossRef
2.
go back to reference Van den Brink H, Zwiers A, Switzer AR, Charlton A, McCreary CR, Goodyear BG, Frayne R, Biessels GJ, Smith EE (2018) Cortical microinfarcts on 3T magnetic resonance imaging in cerebral amyloid angiopathy. Stroke 49(8):1899–1905CrossRef Van den Brink H, Zwiers A, Switzer AR, Charlton A, McCreary CR, Goodyear BG, Frayne R, Biessels GJ, Smith EE (2018) Cortical microinfarcts on 3T magnetic resonance imaging in cerebral amyloid angiopathy. Stroke 49(8):1899–1905CrossRef
3.
go back to reference Kövari E, Gold G, Herrmann FR, Canuto A, Hof PR, Michel JP, Bouras C, Giannakopoulos P (2004) Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke 35(2):410–414CrossRef Kövari E, Gold G, Herrmann FR, Canuto A, Hof PR, Michel JP, Bouras C, Giannakopoulos P (2004) Cortical microinfarcts and demyelination significantly affect cognition in brain aging. Stroke 35(2):410–414CrossRef
4.
go back to reference Gold G, Kövari E, Herrmann FR, Canuto A, Hof PR, Michel JP, Bouras C, Giannakopoulos P (2005) Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke 36(6):1184–1188CrossRef Gold G, Kövari E, Herrmann FR, Canuto A, Hof PR, Michel JP, Bouras C, Giannakopoulos P (2005) Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke 36(6):1184–1188CrossRef
5.
go back to reference Brundel M, de Bresser J, van Dillen JJ, Kappelle LJ, Biessels GJ (2012) Cerebral microinfarcts: a systematic review of neuropathological studies. J Cereb Blood Flow Metab 32(3):425–436CrossRef Brundel M, de Bresser J, van Dillen JJ, Kappelle LJ, Biessels GJ (2012) Cerebral microinfarcts: a systematic review of neuropathological studies. J Cereb Blood Flow Metab 32(3):425–436CrossRef
6.
go back to reference Ferro DA, van Veluw SJ, Koek HL, Exalto LG, Biessels GJ (2017) Cortical cerebral microinfarcts on 3 Tesla MRI in patients with vascular cognitive impairment. J Alzheimers Dis 60(4):1443–1450CrossRef Ferro DA, van Veluw SJ, Koek HL, Exalto LG, Biessels GJ (2017) Cortical cerebral microinfarcts on 3 Tesla MRI in patients with vascular cognitive impairment. J Alzheimers Dis 60(4):1443–1450CrossRef
7.
go back to reference Van Veluw SJ, Hilal S, Kuijf HJ, Ikram MK, Xin X, Yeow TB, Venketasubramanian N, Biessels GJ, Chen C (2015) Cortical microinfarcts on 3T MRI: clinical correlates in memory-clinic patients. Alzheimers Dement 11(12):1500–1509CrossRef Van Veluw SJ, Hilal S, Kuijf HJ, Ikram MK, Xin X, Yeow TB, Venketasubramanian N, Biessels GJ, Chen C (2015) Cortical microinfarcts on 3T MRI: clinical correlates in memory-clinic patients. Alzheimers Dement 11(12):1500–1509CrossRef
8.
go back to reference Del Ser T, Hachinski V, Merskey H, Munoz DG (2005) Alzheimer’s disease with and without cerebral infarcts. J Neurol Sci 231(1–2):3–11PubMed Del Ser T, Hachinski V, Merskey H, Munoz DG (2005) Alzheimer’s disease with and without cerebral infarcts. J Neurol Sci 231(1–2):3–11PubMed
9.
go back to reference Vinters HV, Ellis WG, Zarow C, Zaias BW, Jagust WJ, Mack WJ, Chui HC (2000) Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exp Neurol 59(11):931–945CrossRef Vinters HV, Ellis WG, Zarow C, Zaias BW, Jagust WJ, Mack WJ, Chui HC (2000) Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exp Neurol 59(11):931–945CrossRef
10.
go back to reference Suter OC, Sunthorn T, Kraftsik R, Straubel J, Darekar P, Khalili K, Miklossy J (2002) Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease. Stroke 33(8):1986–1992CrossRef Suter OC, Sunthorn T, Kraftsik R, Straubel J, Darekar P, Khalili K, Miklossy J (2002) Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease. Stroke 33(8):1986–1992CrossRef
11.
go back to reference Van Veluw SJ, Zwanenburg JJ, Engelen-Lee J, Spliet WG, Hendrikse J, Luijten PR, Biessels GJ (2013) In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI. J Cereb Blood Flow Metab 33(3):322–329CrossRef Van Veluw SJ, Zwanenburg JJ, Engelen-Lee J, Spliet WG, Hendrikse J, Luijten PR, Biessels GJ (2013) In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI. J Cereb Blood Flow Metab 33(3):322–329CrossRef
12.
go back to reference Scheffler M, Maturana E, Salomir R, Haller S, Kovari E (2018) Air bubble artifact reduction in post-mortem whole-brain MRI: the influence of receiver bandwidth. Neuroradiology 60(10):1089–1092CrossRef Scheffler M, Maturana E, Salomir R, Haller S, Kovari E (2018) Air bubble artifact reduction in post-mortem whole-brain MRI: the influence of receiver bandwidth. Neuroradiology 60(10):1089–1092CrossRef
13.
go back to reference Miyata M, Kakeda S, Yoneda T, Ide S, Watanabe K, Moriya J, Korogi Y (2018) Signal change of acute cortical and juxtacortical microinfarction on follow-up MRI. AJNR Am J Neuroradiol 39(5):834–840CrossRef Miyata M, Kakeda S, Yoneda T, Ide S, Watanabe K, Moriya J, Korogi Y (2018) Signal change of acute cortical and juxtacortical microinfarction on follow-up MRI. AJNR Am J Neuroradiol 39(5):834–840CrossRef
Metadata
Title
Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging
Authors
Max Scheffler
Rares Salomir
Enrique Maturana
Marie-Louise Montandon
Enikö V. Kövari
Sven Haller
Publication date
01-09-2021
Publisher
Springer Berlin Heidelberg
Published in
Neuroradiology / Issue 9/2021
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-021-02717-8

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