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Neuroradiology

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01-01-2020 | Parkinson's Disease | Functional Neuroradiology

Altered Granger causality connectivity within motor-related regions of patients with Parkinson’s disease: a resting-state fMRI study

Authors: Li Hao, Zhao Sheng, Wang Ruijun, He Zhi Kun, Zhang Peng, Hong Yu

Published in: Neuroradiology | Issue 1/2020

Abstract

Purpose

Although numerous clinical neuroimaging studies have demonstrated that there are functional abnormalities of motor-related regions in patients with Parkinson’s disease (PD) by resting-state functional magnetic resonance imaging (fMRI), little studies have explored the causal interactions within these motor-related regions. The present study aimed to examine Granger causality connectivity patterns within motor-related regions in PD patients.

Methods

Resting-state fMRI was conducted to investigate the causal connectivity differences within motor-related regions between 17 PD patients and 17 matched healthy controls. Subsequently, the relationship between the Unified Parkinson’s Disease Rating Scale scores and causal connectivity values within motor-related regions was examined in PD patients.

Results

An increased causal connectivity from the left premotor cortex (PMC) to right primary motor cortex (M1) was found in PD patients compared with that of healthy controls. Also, increased causal flow from the PMC to M1 was negatively correlated with motor scores.

Conclusion

PD patients have abnormal causal connectivity in specific motor-related regions, which may reflect a compensatory role of motor deficits in PD patients.

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Title: Altered Granger causality connectivity within motor-related regions of patients with Parkinson’s disease: a resting-state fMRI study
Authors: Li Hao
Zhao Sheng
Wang Ruijun
He Zhi Kun
Zhang Peng
Hong Yu
Publication date: 01-01-2020
Publisher: Springer Berlin Heidelberg
Keyword: Parkinson's Disease
Published in: Neuroradiology / Issue 1/2020
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-019-02311-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Altered Granger causality connectivity within motor-related regions of patients with Parkinson’s disease: a resting-state fMRI study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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