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01-01-2020 | Magnetic Resonance Imaging | Spinal Neuroradiology

Evaluation of intervertebral disc using T2 mapping sequences in patients undergoing O₂–O₃ chemiodiscolysis: an instrumental study with clinical correlation

Authors: Federico Bruno, Pierpaolo Palumbo, Emanuele Tommasino, Giampaolo Bianchi, Marco Varrassi, Francesco Arrigoni, Antonio Barile, Ernesto Di Cesare, Carlo Masciocchi, Alessandra Splendiani

Published in: Neuroradiology | Issue 1/2020

Abstract

Purpose

To assess the MRI modifications of the intervertebral disc (IVD) treated by chemiodiscolysis using T2 mapping sequences.

Methods

Thirty sciatica patients (17 males, 13 females, mean age 47.52 years) were enrolled for percutaneous CT-guided O₂–O₃ chemiodiscolysis treatment. As a control group, we enrolled 30 patients who were treated by CT-guided periradicular injections. All patients were submitted to clinical (using VAS and Oswestry Disability index (ODI)) and imaging studies to evaluate the intervertebral disc area (IDA) and T2 mapping values of the IVD before and at 1-month follow-up.

Results

In the study group, pre-treatment IDA mean values were 20.47 ± 1.62 cm², with significant reduction at the follow-up (P < 0.05). Mean pre-treatment T2 relaxation time values were 38.80 ± 4.51 ms, 44.05 ± 0.91 ms, and 45.45 ± 14.11 ms for anterior annulus fibrosus, nucleus pulposus (NP), and posterior annulus fibrosus, respectively, with significant increase at the level of the NP (P < 0.05) at the follow-up. Mean pre-treatment ODI and VAS scores were 21.5 ± 10.6 and 8.5 ± 0.57, with significant improvement at the post-treatment follow-up (P < 0.05). In the control group, despite clinical improvement, we did not find significant IVA reduction nor significant T2 values change after treatment. Correlation analysis of T2 mapping relaxation time values showed significant correlation of NP T2 mapping value with both the reduction of IDA (0.81, P < 0.001) and the improvement of VAS and ODI scores (0.86, P < 0.001) at 1 month. In the control group, we did not find any statistically significant correlation.

Conclusions

T2 mapping may be a useful indicator to predict disc shrinkage and the clinical response to CT-guided O₂–O₃ injection.

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Title: Evaluation of intervertebral disc using T2 mapping sequences in patients undergoing O2–O3 chemiodiscolysis: an instrumental study with clinical correlation
Authors: Federico Bruno
Pierpaolo Palumbo
Emanuele Tommasino
Giampaolo Bianchi
Marco Varrassi
Francesco Arrigoni
Antonio Barile
Ernesto Di Cesare
Carlo Masciocchi
Alessandra Splendiani
Publication date: 01-01-2020
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Disc Herniation
Published in: Neuroradiology / Issue 1/2020
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-019-02308-8

At a glance: The STEP trials

Springer Medicine

Evaluation of intervertebral disc using T2 mapping sequences in patients undergoing O₂–O₃ chemiodiscolysis: an instrumental study with clinical correlation

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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