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Open Access 01-05-2019 | Magnetic Resonance Imaging | Functional Neuroradiology

Grey matter activation by caloric stimulation in patients with unilateral peripheral vestibular hypofunction

Authors: Aleksandra Wypych, Zbigniew Serafin, Maria Marzec, Stanisław Osiński, Łukasz Sielski, Henryk Kaźmierczak, Katarzyna Pawlak-Osińska

Published in: Neuroradiology | Issue 5/2019

Abstract

Purpose

A combination of the caloric test with functional magnetic resonance imaging (fMRI) is a promising method for a comprehensive diagnostics of pathologies of the vestibular system. The aim of this study was to investigate the potential pattern of grey matter local activation in fMRI using cold and hot caloric stimulation in patients presenting unilateral peripheral vestibular injury.

Methods

Forty right-handed participants aged 27 to 56 with the diagnosis of right-sided peripheral vestibular hypofunction were included. Stimulation was performed separately for the right and the left ear with cold (C, 14–15 °C) stimulus and hot (H, 48–49 °C) stimulus. Grey matter activation was assessed in BOLD technique using a 3T scanner.

Results

We observed activity within the parieto-insular vestibular cortex (PIVC), thalamus, insula and retroinsular area, hippocampus, and cerebellum, as well as oculomotor centers located in the precentral gyrus, superior temporal gyrus, and intraparietal sulcus. Cold stimulus resulted in more areas of activation in response to the right ear activation rather than to the left ear. The ipsilateral activity was noted for insular cortex and intraparietal sulcus. The differences between hot and cold stimuli were noted for the right ear.

Conclusions

In this preliminary study, the combination of the caloric test and fMRI allowed to present specific pattern of grey matter activation in patients with unilateral peripheral vestibular injury. Further studies are necessary to develop patterns or cortical maps differentiating various balance disorders and to analyze the dynamics of cortical plasticity after the injury.

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Title: Grey matter activation by caloric stimulation in patients with unilateral peripheral vestibular hypofunction
Authors: Aleksandra Wypych
Zbigniew Serafin
Maria Marzec
Stanisław Osiński
Łukasz Sielski
Henryk Kaźmierczak
Katarzyna Pawlak-Osińska
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Nystagmus
Published in: Neuroradiology / Issue 5/2019
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-019-02194-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Grey matter activation by caloric stimulation in patients with unilateral peripheral vestibular hypofunction

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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