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Neuroradiology

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01-12-2018 | Paediatric Neuroradiology

Assessment of myelination progression in subcortical white matter of children aged 6–48 months using T2-weighted imaging

Authors: Congcong Liu, Chao Jin, Zhijie Jian, Miaomiao Wang, Xianjun Li, Heng Liu, Qinli Sun, Lingxia Zeng, Jian Yang

Published in: Neuroradiology | Issue 12/2018

Abstract

Purpose

This study aims to provide a screening scoring method by assessing the age-related change of subcortical white matter (WM) myelination via T2-weighted imaging (T2WI).

Methods

This study retrospectively recruited 109 children aged 6–48 months without abnormalities on MRI. Based on Parazzini’s study, we developed a modified T2WI-based method to assess subcortical WM myelination (frontal, temporal, parietal, occipital lobes, and insula) by scoring WM’s signal changes. Inter- and intra-observer agreements were evaluated by Bland-Altman plot. Age-related changes of myelination score were explored by locally weighted scatterplot smoothing (LOESS), linear regression, and Spearman correlation coefficients (r). Relationships between diffusion tensor imaging (DTI) metrics and total myelination score were investigated to further validate practicability of the scoring method by tract-based spatial statistics (TBSS).

Results

This method showed good intra-observer (mean difference = 0.18, SD = 0.95) and inter-observer agreements (mean difference = − 0.06, SD = 1.01). The LOESS and linear regression results indicated that myelination proceeded in two phases: a period of rapid growth (6–20 months; slope = 0.561) and one of slower growth (21–48 months; slope = 0.097). Significant correlations between myelination score and age were observed in whole subcortical WM (r = 0.945; P < 0.001) and all regional subcortical WM (r_{_mean} = 0.819, range, 0.664–0.928; P < 0.001). TBSS found significant correlations of WM-DTI metrics with myelination score during the range of 6–20 months, while no significant correlation was observed in 21–48 months.

Conclusion

The modified T2WI-based screening scoring method is easily feasible to assess myelination progression of subcortical WM, especially suitable for children aged 6–20 months. It may show potential in identifying individual developmental abnormalities by scoring assessment in the future clinical practice.

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Title: Assessment of myelination progression in subcortical white matter of children aged 6–48 months using T2-weighted imaging
Authors: Congcong Liu
Chao Jin
Zhijie Jian
Miaomiao Wang
Xianjun Li
Heng Liu
Qinli Sun
Lingxia Zeng
Jian Yang
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 12/2018
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-2108-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Assessment of myelination progression in subcortical white matter of children aged 6–48 months using T2-weighted imaging

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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