Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Neuroradiology
Published in: Neuroradiology 9/2004

01-09-2004 | Diagnostic Neuroradiology

A quantitative measure of myelination development in infants, using MR images

Authors: Dennis P. Carmody, Stanley M. Dunn, Akiza S. Boddie-Willis, J. Kevin DeMarco, Michael Lewis

Published in: Neuroradiology | Issue 9/2004

Login to get access

Abstract

The objective of this study was to measure myelination of frontal lobe changes in infants and young children. Twenty-four cases of infants and children (age range 12–121 months) were evaluated by a quantitative assessment of T2-weighted MR image features. Reliable quantitative changes between white and gray matter correlated with developmental age in a group of children with no neurological findings. Myelination appears to be an increasing exponential function with the greatest rate of change occurring over the first 3 years of life. The quantitative changes observed were in accordance with previous qualitative judgments of myelination development. Children with periventricular leukomalacia (PVL) showed delays in achieving levels of myelination when compared to normal children and adjusted for chronological age. The quantitative measure of myelination development may prove to be useful in assessing the stages of development and helpful in the quantitative descriptions of white matter disorders such as PVL.
Literature
1.
Casey BJ, Giedd JN, Thomas KM (2000) Structural and functional brain development and its relation to cognitive development. Biol Psychol 54:241–257CrossRefPubMed
2.
de Hann M, Thomas KM (2002) Applications of ERP and fMRI techniques to developmental science. Developmental Science 5:335–343CrossRef
3.
Yakovlev PI, Lecours A (1967) The myelogenetic cycles of regional maturation of the brain. In: Minkowski A (ed) Regional development of the brain in early life. Blackwell, Oxford, pp 3–70
4.
Kinney HC, Brody BA, Kloman AS, Gilles F (1988) Sequence of central nervous system myelination in human infancy. J Neuropathol Exp Neurol 47:217–234PubMed
5.
Dambska M, Laure-Kamionowska M (1990) Myelination as a parameter of normal and retarded brain maturation. Brain Dev 12:214–220PubMed
6.
Barkovich AJ (2000) Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol 21:1099–1109PubMed
7.
Barkovich AJ (2000) Pediatric neuroimaging, 3rd edn. Lippincott, Philadelphia
8.
Barkovich AJ (2002) Magnetic resonance imaging: role in the understanding of cerebral malformations. Brain Dev 24:2–12CrossRefPubMed
9.
Barkovich AJ, Kjos BO, Jackson DE Jr, Norman D (1988) Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology 166:173–180PubMed
10.
Bird CR, Hedberg M, Drayer BP et al (1989) MR assessment of myelination in infants and children: usefulness of marker sites. AJNR Am J Neuroradiol 10:731–740PubMed
11.
Dietrich RB, Bradley WG, Zaragoza EJ 4th et al (1988) MR evaluation of early myelination patterns in normal and developmentally delayed infants. AJR Am J Roentgenol 150:889–896PubMed
12.
Holland BA, Haas DK, Norman D et al (1986) MRI of normal brain maturation. AJNR Am J Neuroradiol 7:201–208PubMed
13.
Konishi Y, Hayakawa K, Kuriyama M et al (1993) Developmental features of the brain in preterm and fullterm infants on MR imaging. Early Hum Dev 34:155–162CrossRefPubMed
14.
Martin E, Kikinis R, Zuerrer M et al (1988) Developmental stages of human brain: an MR study. J Comput Assist Tomogr 12:917–922PubMed
15.
McArdle CB, Richardson CJ, Nicholas DA et al (1987) Developmental features of the neonatal brain: MR imaging. Part 1. Gray-white matter differentiation and myelination. Radiology 162:223–229PubMed
16.
van der Knaap MS, Valk J, Bakker CJ et al (1991) Myelination as an expression of the functional maturity of the brain. Dev Med Child Neurol 33:849–857PubMed
17.
Parazzini C, Baldoli C, Scotti G, Triulzi F (2002) Terminal zones of myelination: MR evaluation of children aged 20–40 months. AJNR Am J Neuroradiol 23:1669–1673PubMed
18.
Yamada H, Sadato N, Konishi Y et al (2000) A milestone for normal development of the infantile brain detected by functional MRI. Neurology 55:218–223PubMed
19.
Çoskun A, Lequin M, Segal M, Vigneron DB, Ferriero DM, Barkovich AJ (2001) Quantitative analysis of MR images in asphyxiated neonates: correlation with neurodevelopmental outcome. AJNR Am J Neuroradiol 22:400–405
20.
World Medical Organization (1996) Declaration of Helsinki. BMJ 313(7070):1448–1449
21.
Counsell SJ, Rutherford MA (2002) Magnetic resonance imaging of the newborn brain. Current Paediatrics 12:401–413CrossRef
22.
Boddie-Willis AS (2001) Myelination of the frontal lobe in children with and without brain pathologies. Thesis, Rutgers University, New Brunswick, NJ, USA
23.
Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Thieme, New York
24.
Hershkowitz N (2000) Neurological basis of behavioral development in infancy. Brain Dev 22:411–416CrossRefPubMed
25.
Fuerst KB, Rourke BP (1995) White matter physiology and pathology. In: Rourke BP (ed) Syndrome of nonverbal learning disabilities: Neurodevelopmental manifestations. Guilford Press, New York, pp 27–44
26.
Baierl P, Forster CH, Fendel H et al (1988) Magnetic resonance imaging of normal and pathological white matter maturation. Pediatr Radiol 18:183–189PubMed
27.
Lewis M, Ramsey D (1999) Intentions, consciousness, and pretend play. In: Zelazo PD, Astington JW, Olson DR (eds) Developing theories of intention: Social understanding and self-control. Erlbaum, Mahwah, NJ, USA, pp 77–94
Metadata
Title
A quantitative measure of myelination development in infants, using MR images
Authors
Dennis P. Carmody
Stanley M. Dunn
Akiza S. Boddie-Willis
J. Kevin DeMarco
Michael Lewis
Publication date
01-09-2004
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 9/2004
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-004-1241-z

Other articles of this Issue 9/2004

Neuroradiology 9/2004 Go to the issue

Book Review

Recent Literature

Diagnostic Neuroradiology

Perfusion CT and angio CT in the assessment of acute stroke

Diagnostic Neuroradiology

Choroid plexus carcinomas in children: MRI features and patient outcomes

Diagnostic Neuroradiology

Intrathecal gadolinium (gadopentetate dimeglumine)—enhanced MR cisternography used to determine potential communication between the cerebrospinal fluid pathways and intracranial arachnoid cysts

Diagnostic Neuroradiology

Extracranial–intracranial arterial bypass surgery improves total brain blood supply in selected symptomatic patients with unilateral internal carotid artery occlusion and insufficient collateralization

Diagnostic Neuroradiology

Cerebral perfusion impairment correlates with the decrease of CT density in acute ischaemic stroke