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Neuroradiology

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Open Access 01-07-2018 | Functional Neuroradiology

Diagnostic accuracy of diffusion weighted imaging for differentiation of supratentorial pilocytic astrocytoma and pleomorphic xanthoastrocytoma

Authors: Dejun She, Jianyi Liu, Z. Zeng, Z. Xing, Dairong Cao

Published in: Neuroradiology | Issue 7/2018

Abstract

Purpose

Supratentorial pilocytic astrocytoma (PA) may mimic pleomorphic xanthoastrocytoma (PXA) on conventional MR imaging, and a differentiation is clinically important because of distinct recurrence rate and anaplastic transformation rate. The purpose of this study was to investigate the diagnostic potential of diffusion-weighted imaging (DWI) in differentiating supratentorial PA from PXA.

Methods

We retrospectively reviewed DWI and conventional MR imaging of 16 patients with supratentorial PA and 8 patients with PXA. Variables of mean ADC values (ADC_mean) and minimum ADC values (ADC_min) were calculated from the ROIs containing the contrast-enhancing lesion on DWI. ADC_mean values and ADC_min values were compared among all supratentorial PA and PXA as well as between the subgroup of lobar PA and PXA by using an unpaired Student’s t test. The optimum threshold, sensitivity, specificity, accuracy, and the area under the receiver operating characteristic curve (AUC) were determined.

Results

Both ADC_mean values (1542 ± 186 vs 1084 ± 201 × 10⁻⁶ mm²/s; P < 0.001) and ADC_min values (1355 ± 183 vs 988 ± 180 × 10⁻⁶ mm²/s; P < 0.001) were significantly higher in supratentorial PA compared with PXA. The ADC_mean values and ADC_min values were also significantly higher in lobar PA than those in PXA. The ADC_mean values were useful for differentiating supratentorial PA from PXA, with a threshold value of > 1189.8 × 10⁻⁶ mm²/s (sensitivity, 93.8%; specificity, 100%). The optimal threshold values of > 1189.8 × 10⁻⁶ mm²/s for ADC_mean values provide sensitivity and specificity of 85.7 and 100%, respectively, for discriminating lobar PA from PXA. The optimum threshold value for ADC_min was > 1063.5 × 10⁻⁶ mm²/s.

Conclusion

DWI is helpful in characterization and differentiation of supratentorial PA from PXA.

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Title: Diagnostic accuracy of diffusion weighted imaging for differentiation of supratentorial pilocytic astrocytoma and pleomorphic xanthoastrocytoma
Authors: Dejun She
Jianyi Liu
Z. Zeng
Z. Xing
Dairong Cao
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 7/2018
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-2036-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Diagnostic accuracy of diffusion weighted imaging for differentiation of supratentorial pilocytic astrocytoma and pleomorphic xanthoastrocytoma

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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