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01-07-2018 | Diagnostic Neuroradiology

Noninvasively evaluating the grading and IDH1 mutation status of diffuse gliomas by three-dimensional pseudo-continuous arterial spin labeling and diffusion-weighted imaging

Authors: Tingting Liu, Guang Cheng, Xiaowei Kang, Yibin Xi, Yuanqiang Zhu, Kai Wang, Chao Sun, Jing Ye, Ping Li, Hong Yin

Published in: Neuroradiology | Issue 7/2018

Abstract

Purpose

To noninvasively evaluate the value of three-dimensional pseudo-continuous arterial spin labeling (3D pCASL) and diffusion-weighted imaging (DWI) in diffuse gliomas grading as well as isocitrate dehydrogenase (IDH) 1 mutation status.

Methods

Fifty-six patients with pathologically confirmed diffuse gliomas with preoperative 3D pCASL and DWI were enrolled in this study. The Student’s t test and Mann-Whitney U test were used to evaluate differences in parameters of DWI and 3D pCASL between low and high grade as well as between mutant and wild-type IDH1 diffuse gliomas; receiver operator characteristic (ROC) analysis was used to assess the diagnostic performance. Subsequently, a multivariate stepwise logistic regression analysis was used to identify the independent parameters. Besides, Kruskal-Wallis H test was used to examine the differences among grades II, III, and IV diffuse gliomas.

Results

All parameters but CBF_mean showed significant differences between low- and high-grade diffuse gliomas. In ROC analysis, the AUC of CBF_max, rCBF_mean, rCBF_max, ADC_mean, and ADC_min were 0.701, 0.730, 0.746, 0.810, and 0.856 respectively. Only the value of ADC_min was identified as the independent parameter in the differentiation of low- from high-grade diffuse gliomas. All parameters but CBF_mean showed significant differences among the three grades. And the values of CBF_mean, CBF_max, rCBF_mean, and ADC_mean showed significant differences between mutant and wild-type IDH1 in grade II–III astrocytoma.

Conclusion

Both 3D pCASL and DWI could be useful tools for distinguishing low- from high-grade diffuse gliomas and have the potential to differentiate different IDH1 mutation statuses of astrocytoma.

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Title: Noninvasively evaluating the grading and IDH1 mutation status of diffuse gliomas by three-dimensional pseudo-continuous arterial spin labeling and diffusion-weighted imaging
Authors: Tingting Liu
Guang Cheng
Xiaowei Kang
Yibin Xi
Yuanqiang Zhu
Kai Wang
Chao Sun
Jing Ye
Ping Li
Hong Yin
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 7/2018
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-2021-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Noninvasively evaluating the grading and IDH1 mutation status of diffuse gliomas by three-dimensional pseudo-continuous arterial spin labeling and diffusion-weighted imaging

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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