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Neuroradiology

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01-05-2019 | Glioma | Diagnostic Neuroradiology

Amide proton transfer-weighted MRI in distinguishing high- and low-grade gliomas: a systematic review and meta-analysis

Authors: Chong Hyun Suh, Ji Eun Park, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim, Ho Sung Kim

Published in: Neuroradiology | Issue 5/2019

Abstract

Purpose

Grading of brain gliomas is of clinical importance, and noninvasive molecular imaging may help differentiate low- and high-grade gliomas. We aimed to evaluate the diagnostic performance of amide proton transfer-weighted (APTw) MRI for differentiating low- and high-grade gliomas on 3-T scanners.

Methods

A systematic literature search of Ovid-MEDLINE and EMBASE was performed up to March 28, 2018. Original articles evaluating the diagnostic performance of APTw MRI for differentiating low- and high-grade gliomas were selected. The pooled sensitivity and specificity were calculated using a bivariate random-effects model. A coupled forest plot and a hierarchical summary receiver operating characteristic curve were obtained. Heterogeneity was investigated using Higgins inconsistency index (I²) test. Meta-regression was performed.

Results

Ten original articles with a total of 353 patients were included. High-grade gliomas showed significantly higher APT signal intensity than low-grade gliomas. The pooled sensitivity and specificity for the diagnostic performance of APTw MRI for differentiating low-grade and high-grade gliomas were 88% (95% CI, 77–94%) and 91% (95% CI, 82–96%), respectively. Higgins I² statistic demonstrated heterogeneity in the sensitivity (I² = 68.17%), whereas no heterogeneity was noted in the specificity (I² = 44.84%). In meta-regression, RF saturation power was associated with study heterogeneity. Correlation coefficients between APT signal intensity and Ki-67 cellular proliferation index ranged from 0.430 to 0.597, indicating moderate correlation. All studies showed excellent interobserver agreement.

Conclusions

Although heterogeneous protocols were used, APTw MRI demonstrated excellent diagnostic performance for differentiating low- and high-grade gliomas. APTw MRI could be a reliable technique for glioma grading in clinical practice.

Available only for authorised users

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Title: Amide proton transfer-weighted MRI in distinguishing high- and low-grade gliomas: a systematic review and meta-analysis
Authors: Chong Hyun Suh
Ji Eun Park
Seung Chai Jung
Choong Gon Choi
Sang Joon Kim
Ho Sung Kim
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: Glioma
Glioma
Glioma
Published in: Neuroradiology / Issue 5/2019
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-02152-2

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Amide proton transfer-weighted MRI in distinguishing high- and low-grade gliomas: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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