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Published in: Neuroradiology 12/2017

01-12-2017 | Paediatric Neuroradiology

Follow-up of pineal cysts in children: is it necessary?

Authors: Miro-Pekka Jussila, Päivi Olsén, Niina Salokorpi, Maria Suo-Palosaari

Published in: Neuroradiology | Issue 12/2017

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Abstract

Purpose

Pineal cysts are common incidental findings in children undergoing magnetic resonance imaging (MRI). Several studies have suggested MRI follow-up if the cyst is larger than 10 mm. However, cysts do not usually change during follow-up. Prevalence, growth, and structure of the pineal cysts were analyzed to decide if follow-up MRI is necessary.

Methods

A retrospective review between 2010 and 2015 was performed using 3851 MRI examinations of children aged 0–16 years to detect pineal cysts having a maximum diameter ≥ 10 mm. Eighty-one children with pineal cysts were identified and 79 of them had been controlled by MRI. Cysts were analyzed for the size, growth, and structure.

Results

A total of 1.8% of the children had a pineal cyst with a diameter ≥ 10 mm. Cysts were present in 48 girls (59.3%) and 33 boys (40.7%). Most pineal cysts (70/79) did not significantly grow during the follow-up (median 10 months, range 3–145 months). A total of 11.4% (9/79) of the cysts grew with the biggest change measured from the outer cyst wall sagittal anteroposterior dimension (mean 3.4 mm ± 1.7 mm). Only one cyst grew more than 5 mm. We found no factors correlating with the cyst growth among 9 cysts that grew > 2 mm.

Conclusions

A majority of pineal cysts remained unchanged during the MRI follow-up. Results of this study suggest that routine MRI follow-up of pineal cysts is not necessary in the absence of unusual radiological characteristics or related clinical symptoms.
Literature
1.
go back to reference Al-Holou WN, Garton HJ, Muraszko KM, Ibrahim M, Maher CO (2009) Prevalence of pineal cysts in children and young adults. J Neurosurg Pediatr 4:230–236CrossRefPubMed Al-Holou WN, Garton HJ, Muraszko KM, Ibrahim M, Maher CO (2009) Prevalence of pineal cysts in children and young adults. J Neurosurg Pediatr 4:230–236CrossRefPubMed
2.
go back to reference Al-Holou WN, Maher CO, Muraszko KM, Garton HJ (2010) The natural history of pineal cysts in children and young adults. J Neurosurg Pediatr 5:162–166CrossRefPubMed Al-Holou WN, Maher CO, Muraszko KM, Garton HJ (2010) The natural history of pineal cysts in children and young adults. J Neurosurg Pediatr 5:162–166CrossRefPubMed
3.
go back to reference Kahilogullari G, Massimi L, Di Rocco C (2013) Pineal cysts in children: case-based update. Childs Nerv Syst 29:753–760CrossRefPubMed Kahilogullari G, Massimi L, Di Rocco C (2013) Pineal cysts in children: case-based update. Childs Nerv Syst 29:753–760CrossRefPubMed
4.
go back to reference Pu Y, Mahankali S, Hou J, Li J, Lancaster JL, Gao JH, Appelbaum DE, Fox PT (2007) High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, noncontrast brain MR imaging. AJNR Am J Neuroradiol 28:1706–1709CrossRefPubMed Pu Y, Mahankali S, Hou J, Li J, Lancaster JL, Gao JH, Appelbaum DE, Fox PT (2007) High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, noncontrast brain MR imaging. AJNR Am J Neuroradiol 28:1706–1709CrossRefPubMed
5.
go back to reference Whitehead MT, Oh CC, Choudhri AF (2013) Incidental pineal cysts in children who undergo 3-T MRI. Pediatr Radiol 43:1577–1583CrossRefPubMed Whitehead MT, Oh CC, Choudhri AF (2013) Incidental pineal cysts in children who undergo 3-T MRI. Pediatr Radiol 43:1577–1583CrossRefPubMed
6.
go back to reference Bumb JM, Brockmann MA, Groden C, Al-Zghloul M, Nolte I (2012) TrueFISP of the pediatric pineal gland: volumetric and microstructural analysis. Clin Neuroradiol 22:69–77CrossRefPubMed Bumb JM, Brockmann MA, Groden C, Al-Zghloul M, Nolte I (2012) TrueFISP of the pediatric pineal gland: volumetric and microstructural analysis. Clin Neuroradiol 22:69–77CrossRefPubMed
7.
go back to reference Gur RE, Kaltman D, Melhem ER, Ruparel K, Prabhakaran K, Riley M, Yodh E, Hakonarson H, Satterthwaite T, Gur RC (2013) Incidental findings in youths volunteering for brain MRI research. AJNR Am J Neuroradiol 34:2021–2025CrossRefPubMed Gur RE, Kaltman D, Melhem ER, Ruparel K, Prabhakaran K, Riley M, Yodh E, Hakonarson H, Satterthwaite T, Gur RC (2013) Incidental findings in youths volunteering for brain MRI research. AJNR Am J Neuroradiol 34:2021–2025CrossRefPubMed
8.
go back to reference Nevins EJ, Das K, Bhojak M, Pinto RS, Hoque MN, Jenkinson MD, Chavredakis E (2016) Incidental pineal cysts: is surveillance necessary? World Neurosurg 90:96–102CrossRefPubMed Nevins EJ, Das K, Bhojak M, Pinto RS, Hoque MN, Jenkinson MD, Chavredakis E (2016) Incidental pineal cysts: is surveillance necessary? World Neurosurg 90:96–102CrossRefPubMed
9.
go back to reference Sener RN (1995) The pineal gland: a comparative MR imaging study in children and adults with respect to normal anatomical variations and pineal cysts. Pediatr Radiol 25:245–248CrossRefPubMed Sener RN (1995) The pineal gland: a comparative MR imaging study in children and adults with respect to normal anatomical variations and pineal cysts. Pediatr Radiol 25:245–248CrossRefPubMed
10.
go back to reference Nolte I, Brockmann MA, Gerigk L, Groden C, Scharf J (2010) TrueFISP imaging of the pineal gland: more cysts and more abnormalities. Clin Neurol Neurosurg 112:204–208CrossRefPubMed Nolte I, Brockmann MA, Gerigk L, Groden C, Scharf J (2010) TrueFISP imaging of the pineal gland: more cysts and more abnormalities. Clin Neurol Neurosurg 112:204–208CrossRefPubMed
11.
go back to reference Pastel DA, Mamourian AC, Duhaime AC (2009) Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy. J Neurosurg Pediatrics 4:81–84CrossRef Pastel DA, Mamourian AC, Duhaime AC (2009) Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy. J Neurosurg Pediatrics 4:81–84CrossRef
12.
go back to reference Mandera M, Marcol W, Bierzynska-Macyszyn G, Kluczewska E (2003) Pineal cysts in childhood. Childs Nerv Syst 19:750–755CrossRefPubMed Mandera M, Marcol W, Bierzynska-Macyszyn G, Kluczewska E (2003) Pineal cysts in childhood. Childs Nerv Syst 19:750–755CrossRefPubMed
13.
go back to reference Maher CO, Piatt JH Jr, Section on Neurologic Surgery, American Academy of Pediatrics (2015) Incidental findings on brain and spine imaging in children. Pediatrics 135:e1084–e1096CrossRefPubMed Maher CO, Piatt JH Jr, Section on Neurologic Surgery, American Academy of Pediatrics (2015) Incidental findings on brain and spine imaging in children. Pediatrics 135:e1084–e1096CrossRefPubMed
14.
go back to reference Hayashida Y, Hirai T, Korogi Y, Kochi M, Maruyama N, Yamura M, Yamashita Y (2004) Pineal cystic germinoma with syncytiotrophoblastic giant cells mimicking MR imaging findings of a pineal cyst. AJNR Am J Neuroradiol 25:1538–1540PubMed Hayashida Y, Hirai T, Korogi Y, Kochi M, Maruyama N, Yamura M, Yamashita Y (2004) Pineal cystic germinoma with syncytiotrophoblastic giant cells mimicking MR imaging findings of a pineal cyst. AJNR Am J Neuroradiol 25:1538–1540PubMed
15.
go back to reference Sirin S, de Jong MC, Galluzzi P, Maeder P, Brisse HJ, Castelijns JA, de Graaf P, Goericke SL, European Retinoblastoma Imaging Collaboration (ERIC) (2016) MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland. Neuroradiology 58:713–721CrossRefPubMedPubMedCentral Sirin S, de Jong MC, Galluzzi P, Maeder P, Brisse HJ, Castelijns JA, de Graaf P, Goericke SL, European Retinoblastoma Imaging Collaboration (ERIC) (2016) MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland. Neuroradiology 58:713–721CrossRefPubMedPubMedCentral
16.
go back to reference de Jong MC, Kors WA, de Graaf P, Castelijns JA, Kivela T, Moll AC (2014) Trilateral retinoblastoma: a systematic review and meta-analysis. Lancet Oncol 15(10):1157–1167CrossRefPubMed de Jong MC, Kors WA, de Graaf P, Castelijns JA, Kivela T, Moll AC (2014) Trilateral retinoblastoma: a systematic review and meta-analysis. Lancet Oncol 15(10):1157–1167CrossRefPubMed
17.
go back to reference de Jong MC, Kors WA, de Graaf P, Castelijns JA, Moll AC, Kivela T (2015) The incidence of trilateral retinoblastoma: a systematic review and meta-analysis. Am J Ophthalmol 160(6):1116–1126.e5CrossRefPubMed de Jong MC, Kors WA, de Graaf P, Castelijns JA, Moll AC, Kivela T (2015) The incidence of trilateral retinoblastoma: a systematic review and meta-analysis. Am J Ophthalmol 160(6):1116–1126.e5CrossRefPubMed
18.
go back to reference Gupta AK, Jones M, Prelog K, Bui J, Zhu J, Ng A, Dalla-Pozza L (2016) Pineal cysts-a benign association with familial retinoblastoma. Pediatr Hematol Oncol 33(6):408–414CrossRefPubMed Gupta AK, Jones M, Prelog K, Bui J, Zhu J, Ng A, Dalla-Pozza L (2016) Pineal cysts-a benign association with familial retinoblastoma. Pediatr Hematol Oncol 33(6):408–414CrossRefPubMed
19.
go back to reference Fakhran S, Escott EJ (2008) Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging? AJNR Am J Neuroradiol 29:159–163CrossRefPubMed Fakhran S, Escott EJ (2008) Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging? AJNR Am J Neuroradiol 29:159–163CrossRefPubMed
20.
go back to reference Barboriak DP, Lee L, Provenzale JM (2001) Serial MR imaging of pineal cysts: implications for natural history and follow-up. AJR Am J Roentgenol 176:737–743CrossRefPubMed Barboriak DP, Lee L, Provenzale JM (2001) Serial MR imaging of pineal cysts: implications for natural history and follow-up. AJR Am J Roentgenol 176:737–743CrossRefPubMed
21.
go back to reference Al-Holou WN, Terman SW, Kilburg C, Garton HJ, Muraszko KM, Chandler WF, Ibrahim M, Maher CO (2011) Prevalence and natural history of pineal cysts in adults. J Neurosurg 115:1106–1114CrossRefPubMed Al-Holou WN, Terman SW, Kilburg C, Garton HJ, Muraszko KM, Chandler WF, Ibrahim M, Maher CO (2011) Prevalence and natural history of pineal cysts in adults. J Neurosurg 115:1106–1114CrossRefPubMed
22.
go back to reference Cauley KA, Linnell GJ, Braff SP, Filippi CG (2009) Serial follow-up MRI of indeterminate cystic lesions of the pineal region: experience at a rural tertiary care referral center. AJR Am J Roentgenol 193:533–537CrossRefPubMed Cauley KA, Linnell GJ, Braff SP, Filippi CG (2009) Serial follow-up MRI of indeterminate cystic lesions of the pineal region: experience at a rural tertiary care referral center. AJR Am J Roentgenol 193:533–537CrossRefPubMed
23.
go back to reference Fetell MR, Bruce JN, Burke AM, Cross DT, Torres RA, Powers JM, Stein BM (1991) Non-neoplastic pineal cysts. Neurology 41:1034–1040CrossRefPubMed Fetell MR, Bruce JN, Burke AM, Cross DT, Torres RA, Powers JM, Stein BM (1991) Non-neoplastic pineal cysts. Neurology 41:1034–1040CrossRefPubMed
24.
go back to reference Michielsen G, Benoit Y, Baert E, Meire F, Caemaert J (2002) Symptomatic pineal cysts: clinical manifestations and management. Acta Neurochir 144:233–242CrossRefPubMed Michielsen G, Benoit Y, Baert E, Meire F, Caemaert J (2002) Symptomatic pineal cysts: clinical manifestations and management. Acta Neurochir 144:233–242CrossRefPubMed
26.
go back to reference Seifert CL, Woeller A, Valet M, Zimmer C, Berthele A, Tolle T, Sprenger T (2008) Headaches and pineal cyst: a case-control study. Headache 48:448–452CrossRefPubMed Seifert CL, Woeller A, Valet M, Zimmer C, Berthele A, Tolle T, Sprenger T (2008) Headaches and pineal cyst: a case-control study. Headache 48:448–452CrossRefPubMed
27.
go back to reference Osborn AG, Preece MT (2006) Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology 239:650–664CrossRefPubMed Osborn AG, Preece MT (2006) Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology 239:650–664CrossRefPubMed
28.
go back to reference Di Chirico A, Di Rocco F, Velardi F (2001) Spontaneous regression of a symptomatic pineal cyst after endoscopic third-ventriculostomy. Childs Nerv Syst 17:42–46CrossRefPubMed Di Chirico A, Di Rocco F, Velardi F (2001) Spontaneous regression of a symptomatic pineal cyst after endoscopic third-ventriculostomy. Childs Nerv Syst 17:42–46CrossRefPubMed
29.
go back to reference Gaillard F, Jones J (2010) Masses of the pineal region: clinical presentation and radiographic features. Postgrad Med J 86:597–607CrossRefPubMed Gaillard F, Jones J (2010) Masses of the pineal region: clinical presentation and radiographic features. Postgrad Med J 86:597–607CrossRefPubMed
30.
go back to reference Golzarian J, Balériaux D, Bank WO, Matos C, Flament-Durand J (1993) Pineal cyst: normal or pathological? Neuroradiology 35:251–253CrossRefPubMed Golzarian J, Balériaux D, Bank WO, Matos C, Flament-Durand J (1993) Pineal cyst: normal or pathological? Neuroradiology 35:251–253CrossRefPubMed
31.
go back to reference Mamourian AC, Yarnell T (1991) Enhancement of pineal cysts on MR images. AJNR Am J Neuroradiol 12:773–774PubMed Mamourian AC, Yarnell T (1991) Enhancement of pineal cysts on MR images. AJNR Am J Neuroradiol 12:773–774PubMed
32.
go back to reference Smith AB, Rushing EJ, Smirniotopoulos JG (2010) From the archives of the AFIP: lesions of the pineal region: radiologic-pathologic correlation. Radiographics 30:2001–2020CrossRefPubMed Smith AB, Rushing EJ, Smirniotopoulos JG (2010) From the archives of the AFIP: lesions of the pineal region: radiologic-pathologic correlation. Radiographics 30:2001–2020CrossRefPubMed
33.
go back to reference Fleege MA, Miller GM, Fletcher GP, Fain JS, Scheithauer BW (1994) Benign glial cysts of the pineal gland: unusual imaging characteristics with histologic correlation. AJNR Am J Neuroradiol 15:161–166PubMed Fleege MA, Miller GM, Fletcher GP, Fain JS, Scheithauer BW (1994) Benign glial cysts of the pineal gland: unusual imaging characteristics with histologic correlation. AJNR Am J Neuroradiol 15:161–166PubMed
34.
go back to reference Steven DA, McGinn GJ, McClarty BM (1995) A choroid plexus papilloma arising from an incidental pineal cyst. AJNR 17:939–942 Steven DA, McGinn GJ, McClarty BM (1995) A choroid plexus papilloma arising from an incidental pineal cyst. AJNR 17:939–942
35.
36.
go back to reference Hao D, Ai T, Goerner F, Hu X, Runge VM, Tweedle M (2012) MRI contrast agents: basic chemistry and safety. J Magn Reson Imaging 36:1060–1071CrossRefPubMed Hao D, Ai T, Goerner F, Hu X, Runge VM, Tweedle M (2012) MRI contrast agents: basic chemistry and safety. J Magn Reson Imaging 36:1060–1071CrossRefPubMed
Metadata
Title
Follow-up of pineal cysts in children: is it necessary?
Authors
Miro-Pekka Jussila
Päivi Olsén
Niina Salokorpi
Maria Suo-Palosaari
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Neuroradiology / Issue 12/2017
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-017-1926-8

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