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Clinical Neuroradiology
Published in: Clinical Neuroradiology 1/2012

01-03-2012 | Original Article

TrueFISP of the Pediatric Pineal Gland

Volumetric and Microstructural Analysis

Authors: J. M. Bumb, M. A. Brockmann, C. Groden, M. Al-Zghloul, I. Nölte

Published in: Clinical Neuroradiology | Issue 1/2012

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Abstract

Purpose

Although high-resolution 3D-imaging has markedly improved the imaging of the pediatric pineal gland, the prevalences of typical and atypical cysts as well as in vivo volumes are unknown.
The purpose of this study was to compare the frequency of typical and atypical cysts using high-resolution 3D-sequence true fast imaging with steady state precession (trueFISP) and standard sequences and to directly measure the pineal volume in a large pediatric population.

Methods

In 54 consecutively examined children (age 0–17 years, mean age 5.4 ± 5.6 years, 44% female, 56% male) the prevalence of typical and atypical cysts (thickened rim, trabeculations, asymmetry) was determined using trueFISP (isotropic, 0.8 mm) and standard sequences, 1.5-T, T1-weighted spin echo (T1-SE), T2-weighted turbo spin echo (T2-TSE) and fluid attenuated inversion recovery (FLAIR). Indistinct findings were noted separately. Volumetry was based on the trueFISP datasets. Solid and cystic compartments were approached separately. The pineal volume was correlated to gender and age.

Results

The detected frequency of pineal cysts was higher in trueFISP (57.4%) than in standard sequences (T1-SE 7.4%, T2-TSE 14.8%, and FLAIR 13.0%). In trueFISP 66.3% of the detected cysts were classified as atypical (standard sequences 0%). Indistinct findings were lowest in trueFISP. The mean pineal volume was 94.3 ± 159.1 mm³ and no gender related differences were found. Age and volume showed a moderate correlation (r = 0.382) which was remarkably higher in completely solid glands (r = 0.659).

Conclusions

TrueFISP imaging improves the detection of pineal cysts in children. A typical cysts are frequently detected as an incidental finding. Volumetric analysis of the pediatric pineal gland is feasible and reveals enormous variation. Whereas gender effects are negligible, the pineal volume in children is dependant on age.
Literature
1.
Hasegawa A, Mori W. Morphometry of the human pineal gland: relationship to the adrenal cortex. Acta Pathol Jpn. 1980;30(3):407–10.PubMed
2.
3.
Tapp E, Huxley M. The weight and degree of calcification of the pineal gland. J Pathol. 1971;105(1):31–9.PubMedCrossRef
4.
Tapp E, Huxley M. The histological appearance of the human pineal gland from puberty to old age. J Pathol. 1972;108(2):137–44.PubMedCrossRef
5.
Schmitz SA, Platzek I, Kunz D, Mahlberg R, Wolf KJ, Heidenreich JO. Computed tomography of the human pineal gland for study of the sleep-wake rhythm: reproducibility of a semi-quantitative approach. Acta Radiol. 2006;47(8):865–71.PubMedCrossRef
6.
Sener RN. The pineal gland: a comparative MR imaging study in children and adults with respect to normal anatomical variations and pineal cysts. Pediatr Radiol. 1995;25(4):245–8.PubMedCrossRef
7.
Sumida M, Barkovich AJ, Newton TH. Development of the pineal gland: measurement with MR. AJNR Am J Neuroradiol. 1996;17(2):233–6.PubMed
8.
Nolte I, Brockmann MA, Gerigk L, Groden C, Scharf J. TrueFISP imaging of the pineal gland: more cysts and more abnormalities. Clin Neurol Neurosurg. 2010;112(3):204–8. doi:s0303-8467(09)00307-2 [pii] 10.1016/j.clineuro.2009.11.010.PubMedCrossRef
9.
Nölte I, Lütkhoff AT, Stuck BA, Lemmer B, Schredl M, Findeisen P, et al. Pineal volume and circadian melatonin profile in healthy volunteers: an interdisciplinary approach. J Magn Reson Imaging. 2009;30(3):499–505. doi:10.1002/jmri.21872.PubMedCrossRef
10.
Pu Y, Mahankali S, Hou J, Li J, Lancaster JL, Gao JH, et al. High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, noncontrast brain MR imaging. AJNR Am J Neuroradiol. 2007;28(9):1706–9.PubMedCrossRef
11.
Sun B, Wang D, Tang Y, Fan L, Lin X, Yu T, et al. The pineal volume: a three-dimensional volumetric study in healthy young adults using 3.0 T MR data. Int J Dev Neurosci. 2009;27(7):655–60. doi:s0736-5748(09)00117-8 [pii] 10.1016/j.ijdevneu.2009.08.002.PubMedCrossRef
12.
Hasegawa A, Ohtsubo K, Mori W. Pineal gland in old age; quantitative and qualitative morphological study of 168 human autopsy cases. Brain Res. 1987;409(2):343–9.PubMedCrossRef
13.
Golan J, Torres K, Staskiewicz GJ, Opielak G, Maciejewski R. Morphometric parameters of the human pineal gland in relation to age, body weight and height. Folia Morphol (Warsz). 2002;61(2):111–3.
14.
Rodin AE, Overall J. Statistical relationships of weight of the human pineal to age and malignancy. Cancer. 1967;20(8):1203–14.PubMedCrossRef
15.
Lee DH, Norman D, Newton TH. MR imaging of pineal cysts. J Comput Assist Tomogr. 1987;11(4):586–90.PubMedCrossRef
16.
Mandera M, Marcol W, Bierzynska-Macyszyn G, Kluczewska E. Pineal cysts in childhood. Childs Nerv Syst. 2003;19(10–11):750–5.PubMedCrossRef
17.
Schmidt F, Penka B, Trauner M, Reinsperger L, Ranner G, Ebner F, et al. Lack of pineal growth during childhood. J Clin Endocrinol Metab. 1995;80(4):1221–5.PubMedCrossRef
18.
Mamourian AC, Towfighi J. Pineal cysts: MR imaging. AJNR Am J Neuroradiol. 1986;7(6):1081–6.PubMed
19.
Golzarian J, Baleriaux D, Bank WO, Matos C, Flament-Durand J. Pineal cyst: normal or pathological? Neuroradiology. 1993;35(4):251–3.PubMedCrossRef
20.
Inoue Y, Saiwai S, Miyamoto T, Katsuyama J. Enhanced high-resolution sagittal MRI of normal pineal glands. J Comput Assist Tomogr. 1994;18(2):182–6.PubMedCrossRef
21.
Pastel DA, Mamourian AC, Duhaime AC. Internal structure in pineal cysts on high-resolution magnetic resonance imaging: not a sign of malignancy. J Neurosurg Pediatr. 2009;4(1):81–4. doi:10.3171/2008.5.17681 [pii] 10.3171/2008.5.17681.PubMedCrossRef
22.
Barboriak DP, Lee L, Provenzale JM. Serial MR imaging of pineal cysts: implications for natural history and follow-up. AJR Am J Roentgenol. 2001;176(3):737–43.PubMed
23.
Cooper E. The human pineal gland and pineal cysts. J Anatom. 1932;67:28–46.
24.
Engel U, Gottschalk S, Niehaus L, Lehmann R, May C, Vogel S et al. Cystic lesions of the pineal region—MRI and pathology. Neuroradiology. 2000;42(6):399–402.PubMedCrossRef
25.
Hajdu SI, Porro RS, Lieberman PH, Foote FW Jr. Degeneration of the pineal gland of patients with cancer. Cancer. 1972;29(3):706–9.PubMedCrossRef
26.
Megyeri L. Cystic changes in the pineal body. Frankf Z Pathol. 1960;70:699–704.PubMed
27.
Caldas JG, Doyon D, Lederman H, Carlier R. Magnetic resonance study of the pineal region. Normal pineal gland and simple cysts. Arq Neuropsiquiatr. 1998;56(2):237–44.PubMedCrossRef
28.
Katzman GL, Dagher AP, Patronas NJ. Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers. JAMA. 1999;282(1):36–9.PubMedCrossRef
29.
Lum GB, Williams JP, Machen BC, Akkaraju V. Benign cystic pineal lesions by magnetic resonance imaging. J Comput Tomogr. 1987;11(3):228–35.PubMedCrossRef
30.
Mamourian A, Towfighi J. MR of pineal cysts. AJNR Am J Neuroradiol. 1994;15(9):1796–7.PubMed
31.
Petitcolin V, Garcier JM, Mohammedi R, Ravel A, Mofid R, Viallet JF, et al. Prevalence and morphology of pineal cysts discovered at pituitary MRI: review of 1844 examinations. J Radiol. 2002;83(2 Pt 1):141–5.PubMed
32.
Warmuth-Metz M, Bison B, Leykamm S. Neuroradiologic review in pediatric brain tumor studies. Klin Neuroradiol. 2009;19(4):263–73. doi:1007/s00062-009-9029-5.PubMedCrossRef
33.
Hattingen E, Blasel S, Nichtweiss M, Zanella FE, Weidauer S. MR imaging of midbrain pathologies. Clin Neuroradiol. 2010;20(2):81–97. doi:1007/s00062-010-0009-6.PubMedCrossRef
34.
Briellmann RS, Syngeniotis A, Jackson GD. Comparison of hippocampal volumetry at 1.5 T and at 3 T. Epilepsia. 2001;42(8):1021–4. doi:epi02201 [pii].PubMedCrossRef
35.
Horinek D, Brezova V, Nimsky C, Belsan T, Martinkovic L, Masopust V, et al. The MRI volumetry of the posterior fossa and its substructures in trigeminal neuralgia: a validated study. Acta Neurochir (Wien). 2009;151(6):669–75.CrossRef
36.
Hentschel F, von Kummer R. Response of the German Society of Neuroradiology to the guideline: “Ethically Appropriate Reaction to Incidental Imaging Findings in Brain Research”, suggested by Thomas Heinemann, Institut fur Wissenschaft und Ethik, and Christian Hoppe, Klinik fur Epileptologie, Universitat Bonn, Germany, on January 9, 2009. Klin Neuroradiol. 2009;19(2):108–10.PubMedCrossRef
37.
Heinemann T, Hoppe C, Weber B, Elger CE. Ethically appropriate handling of incidental findings in human neuroimaging research: letter to the guest editorial of Frank Hentschel and Rudiger von Kummer [2]. Klin Neuroradiol. 2009;19(3):242–3; author reply 4.PubMedCrossRef
38.
Waldhauser F, Kovacs J, Reiter E. Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders. Exp Gerontol. 1998;33(7–8):759–72.PubMedCrossRef
Metadata
Title
TrueFISP of the Pediatric Pineal Gland
Volumetric and Microstructural Analysis
Authors
J. M. Bumb
M. A. Brockmann
C. Groden
M. Al-Zghloul
I. Nölte
Publication date
01-03-2012
Publisher
Springer-Verlag
Published in
Clinical Neuroradiology / Issue 1/2012
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-011-0110-5

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