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Open Access 01-01-2020 | Cystic Fibrosis | Review

Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?

Authors: Karen Maes, Jef Serré, Carolien Mathyssen, Wim Janssens, Ghislaine Gayan-Ramirez

Published in: Calcified Tissue International | Issue 1/2020

Abstract

Patients with respiratory diseases such as cystic fibrosis, chronic obstructive pulmonary disease, or asthma often experience an acute worsening of respiratory symptoms, termed exacerbations. Although the course of exacerbations is disease specific, they are mostly triggered by a respiratory infection. Exacerbations often require hospitalization and are an important cause of mortality. Treatments of exacerbations aim to minimize the negative impact and to prevent subsequent events. Despite many existing therapy options, many patients do not benefit from therapy and suffer from recurrent events. Vitamin D deficiency is a worldwide problem and is extremely prevalent in these patients. Vitamin D, known for its calcemic effects, also has immunomodulatory and anti-infectious actions and can therefore be a possible agent to treat or prevent exacerbations. This review will focus on vitamin D as a potential candidate to treat or prevent exacerbations in CF, COPD, and asthma.

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Title: Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?
Authors: Karen Maes
Jef Serré
Carolien Mathyssen
Wim Janssens
Ghislaine Gayan-Ramirez
Publication date: 01-01-2020
Publisher: Springer US
Keywords: Cystic Fibrosis
Bronchial Asthma
Vitamin D Deficiency
Cystic Fibrosis
Chronic Obstructive Lung Disease
Published in: Calcified Tissue International / Issue 1/2020
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-019-00591-4

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Targeting Vitamin D Deficiency to Limit Exacerbations in Respiratory Diseases: Utopia or Strategy With Potential?

Abstract

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