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01-11-2018 | Original Research

Effects of Vitamin D3 Supplementation on Muscle Strength, Mass, and Physical Performance in Women with Vitamin D Insufficiency: A Randomized Placebo-Controlled Trial

Authors: Lise Sofie Bislev, Lene Langagergaard Rødbro, Lars Rolighed, Tanja Sikjaer, Lars Rejnmark

Published in: Calcified Tissue International | Issue 5/2018

Abstract

Vitamin D insufficiency and hyperparathyroidism have been associated with reduced muscle strength, physical performance, postural stability, well-being, and quality of life. In a double-blinded, randomized placebo-controlled trial, we aimed to investigate effects of vitamin D3 supplementation on above-mentioned outcomes in healthy community-dwelling postmenopausal women with plasma levels of 25-hydroxyvitamin D (25(OH)D) below < 50 nmol/l and high parathyroid hormone (PTH) levels. Participants (N = 81) were 1:1 treated with vitamin D3, 70 µg (2800 IU)/day or identical placebo for three months during wintertime (56°N). Vitamin D3 supplementation increased levels of 25(OH)D and 1,25(OH)₂D by 230% (95% CI 189 to 272)%, p < 0.001 and 58% (190 to 271%), p < 0.001, respectively, and reduced PTH by 17% (− 23 to − 11%), p < 0.001. Compared with placebo, vitamin D3 significantly reduced maximal handgrip strength by 9% (− 15 to − 3%; p < 0.01) and knee flexion strength by 13% (− 24 to − 2%; p = 0.02) and increased the time spent on performing the Timed Up and Go test by 4.4%; (0.1–8.6%; p < 0.05). Levels of physical activity, total lean body mass, appendicular lean mass index, postural stability, well-being, and quality of life did not change in response to treatment. Compared with placebo, a daily supplement with a relatively high dose of vitamin D3 had no beneficial effects on any outcomes. In some measures of muscle strength and physical performance, we even saw a small unfavorable effect. Our data call for caution on use of relatively high daily doses of vitamin D3 in the treatment of vitamin D insufficiency.

Rejnmark L, Bislev LS, Cashman KD, Eiríksdottir G, Gaksch M, Grü Bler M et al (2017) Non-skeletal health effects of vitamin D supplementation: a systematic review on findings from meta-analyses summarizing trial data. PLoS ONE 12:1–39. https://doi.org/10.1371/journal.pone.0180512 CrossRef

Autier P, Mullie P, Macacu A, Dragomir M, Boniol M, Coppens K et al (2017) Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol 5:986–1004. https://doi.org/10.1016/S2213-8587(17)30357-1 CrossRefPubMed

Beaudart C, Buckinx F, Rabenda V, Gillain S, Cavalier E, Slomian J et al (2014) The effects of vitamin d on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials. J Clin Endocrinol Metab 99:4336–4345. https://doi.org/10.1210/jc.2014-1742 CrossRefPubMed

Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O (2009) Vitamin D-related changes in physical performance: a systematic review. J Nutr Heal Aging 13:893–898. https://doi.org/10.1007/s12603-009-0248-x CrossRef

Muir SW, Montero-Odasso M (2011) Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc 59:2291–2300. https://doi.org/10.1111/j.1532-5415.2011.03733.x CrossRefPubMed

Raftery TC, Healy M, Cox G, McNamara D, O’Sullivan M (2013) Vitamin D supplementation improves muscle strength, fatigue and quality of life in patients with crohn’s disease in remission: Results of a randomized double-blind placebo-controlled study. Gastroenterology 144:S227. https://doi.org/10.1016/S0016-5085(13)60804-5 CrossRef

Stein M, Wark J, Scherer S, Waltson L, Chick P, Carlantonio M et al (1999) Falls relate to vitamin D and parathyroid hormone in an Australian nursing home hostel. J Am Geriatr Soc 47:1195–1201CrossRefPubMed

de Souza Genaro P, de Medeiros Pinheiro M, Szejnfeld VL, Martini LA (2015) Secondary hyperparathyroidism and its relationship with sarcopenia in elderly women. Arch Gerontol Geriatr 60:349–353. https://doi.org/10.1016/j.archger.2015.01.005 CrossRefPubMed

Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C (2000) Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res 15:1113–1118. https://doi.org/10.1359/jbmr.2000.15.6.1113 CrossRefPubMed

10.

Bird ML, El Haber N, Batchelor F, Hill K, Wark JD (2018) Vitamin D and parathyroid hormone are associated with gait instability and poor balance performance in mid-age to older aged women. Gait Posture 59:71–75. https://doi.org/10.1016/j.gaitpost.2017.09.036 CrossRefPubMed

11.

Sambrook PN, Chen JS, March LM, Cameron ID, Cumming RG, Lord SR et al (2004) Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. J Clin Endocrinol Metab 89:1572–1576. https://doi.org/10.1210/jc.2003-031782 CrossRefPubMed

12.

Rolighed L, Rejnmark L, Sikjaer T, Heickendorff L, Vestergaard P, Mosekilde L et al (2015) No beneficial effects of vitamin D supplementation on muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial. Eur J Endocrinol 172:609–617. https://doi.org/10.1530/EJE-14-0940 CrossRefPubMed

13.

Rejnmark L (2011) Effects of vitamin D on muscle function and performance: a review of evidence from randomized controlled trials. Ther Adv Chronic Dis 2:25–37. https://doi.org/10.1177/2040622310381934 CrossRefPubMedPubMedCentral

14.

Latham NK, Anderson CS, Reid IR (2003) Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review. J Am Geriatr Soc 51:1219–1226. https://doi.org/10.1046/j.1532-5415.2003.51405.x CrossRefPubMed

15.

Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL (2011) Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int 22:859–871. https://doi.org/10.1007/s00198-010-1407-y CrossRefPubMed

16.

Rosendahl-Riise H, Spielau U, Ranhoff AH, Gudbrandsen OA, Dierkes J (2017) Vitamin D supplementation and its influence on muscle strength and mobility in community-dwelling older persons: a systematic review and meta-analysis. J Hum Nutr Diet 30:3–15. https://doi.org/10.1111/jhn.12394 CrossRefPubMed

17.

Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R et al (2009) Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 339:843. https://doi.org/10.1136/bmj.b3692 CrossRef

18.

Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM et al (2011) The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab 96:2997–3006. https://doi.org/10.1210/jc.2011-1193 CrossRefPubMed

19.

Bouillon R (2017) Comparative analysis of nutritional guidelines for vitamin D. Nat Rev Endocrinol 13:466–479. https://doi.org/10.1038/nrendo.2017.31 CrossRefPubMed

20.

Bislev LS, Langagergaard Rødbro L, Nørgaard Bech J, Bjerregaard Pedersen E, Rolighed L, Sikjaer T et al (2018) Effects of treatment with an angiotensin 2 receptor blocker and/or vitamin D3 on parathyroid hormone and aldosterone: a randomized, placebo-controlled trial. Clin Endocrinol (Oxf). https://doi.org/10.1111/cen.13734 CrossRef

21.

Hermann AP, Thomsen J, Vestergaard P, Mosekilde LCP (1999) Assessment of calcium intake. A quick method comparerd to a 7 days food diary. Calcif Tissue Int 64:82

22.

Curb JD, Ceria-Ulep CD, Rodriguez BL, Grove J, Guralnik J, Willcox BJ et al (2006) Performance-based measures of physical function for high-function populations. J Am Geriatr Soc 54:737–742. https://doi.org/10.1111/j.1532-5415.2006.00700.x CrossRefPubMed

23.

Podsiadlo D, Richardson S (1991) The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39:142–148CrossRefPubMed

24.

Annuzzi-Sucich M, Prestwood KM, Kenny AM (2002) Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol 57:M772–M777CrossRef

25.

Aadahl M, Jørgensen T (2003) Validation of a new self-report instrument for measuring physical activity. Med Sci Sports Exerc 35:1196–1202. https://doi.org/10.1249/01.MSS.0000074446.02192.14 CrossRefPubMed

26.

Bjorner JB, Thunedborg K, Kristensen TS, Modvig J, Bech P (1998) The Danish SF-36 health survey: translation and preliminary validity studies. J Clin Epidemiol 51:991–999CrossRefPubMed

27.

Topp CW, Østergaard SD, Søndergaard S, Bech P (2015) The WHO-5 well-being index: a systematic review of the literature. Psychother Psychosom 84:167–176. https://doi.org/10.1159/000376585 CrossRefPubMed

28.

Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Andersen H et al (2000) Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif Tissue Int 66:419–424CrossRefPubMed

29.

Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H (2009) Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 20:315–322. https://doi.org/10.1007/s00198-008-0662-7 CrossRefPubMed

30.

Bischoff H, Stahelin HB, Dick W, Akos R, Knecht M, Salis C et al (2003) Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res 18:343–351CrossRefPubMed

31.

Bunout D, Barrera G, Leiva L, Gattas V, de la Maza MP, Avendaño M et al (2006) Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Gerontol 41:746–752. https://doi.org/10.1016/j.exger.2006.05.001 CrossRefPubMed

32.

Gupta R, Sharma U, Gupta N, Kalaivani M, Singh U, Guleria R et al (2010) Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D-deficient Asian Indians: a randomized, controlled trial. Clin Endocrinol (Oxf) 73:445–451. https://doi.org/10.1111/j.1365-2265.2010.03816.x CrossRef

33.

Moreira-Pfrimer LDF, Pedrosa MAC, Teixeira L, Lazaretti-Castro M (2009) Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab 54:291–300. https://doi.org/10.1159/000235874 CrossRefPubMed

34.

Patil R, Karinkanta S, Tokola K, Kannus P, Sievänen H, Uusi-Rasi K (2016) Effects of vitamin D and exercise on the wellbeing of older community-dwelling women: a randomized controlled trial. Gerontology 62:401–408. https://doi.org/10.1159/000442441 CrossRefPubMed

35.

Mason C, Tapsoba JD, Duggan C, Imayama I (2016) Effects of vitamin D3 supplementation on lean mass, muscle strength, and bone mineral density during weight loss: a double-blind randomized controlled trial. J Am Geriatr Soc. https://doi.org/10.1111/jgs.14049 CrossRefPubMedPubMedCentral

36.

Diamond T, Wong YK, Golombick T (2013) Effect of oral cholecalciferol 2,000 versus 5,000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency. Osteoporos Int 24:1101–1105. https://doi.org/10.1007/s00198-012-1944-7 CrossRefPubMed

37.

Janssen HCJP, Samson MM, Verhaar HJJ (2010) Muscle strength and mobility in vitamin D-insufficient female geriatric patients: a randomized controlled trial on vitamin D and calcium supplementation. Aging Clin Exp Res 22:78–84. https://doi.org/10.1007/BF03324819 CrossRefPubMed

38.

Lips P, Binkley N, Pfeifer M, Recker R, Samanta S, Cohn DA et al (2010) Once-weekly dose of 8400 IU vitamin D 3 compared with placebo: effects on neuromuscular function and tolerability in older adults with. Am J Clin Nutr 91:985–991. https://doi.org/10.3945/ajcn.2009.28113.Vitamin CrossRefPubMed

39.

Rafiq R, Prins HJ, Boersma WG, Daniels JM, den Heijer M, Lips P et al (2017) Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial. Int J Chron Obstruct Pulmon Dis 12:2583–2592. https://doi.org/10.2147/COPD.S132117 CrossRefPubMedPubMedCentral

40.

Saha S, Goswami R, Ramakrishnan L, Vishnubhatla S, Mahtab S, Kar P et al. Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: randomized control trial. Clin Endocrinol (Oxf) 2017:217–226. https://doi.org/10.1111/cen.13507 CrossRefPubMed

41.

Witte KK, Byrom R, Gierula J, Paton MF, Jamil HA, Lowry JE et al (2016) Effects of vitamin D on cardiac function in patients with chronic HF: the VINDICATE study. J Am Coll Cardiol 67:2593–2603. https://doi.org/10.1016/j.jacc.2016.03.508 CrossRefPubMedPubMedCentral

42.

Uusi-Rasi K, Patil R, Karinkanta S, Kannus P, Tokola K, Lamberg-Allardt C et al (2015) Exercise and vitamin din fall prevention among older women a randomized clinical trial. JAMA Intern Med 175:703–711. https://doi.org/10.1001/jamainternmed.2015.0225 CrossRefPubMed

43.

Bischoff-Ferrari HA, Dawson-Hughes B, John Orav E, Staehelin HB, Meyer OW, Theiler R et al (2016) Monthly high-dose vitamin D treatment for the prevention of functional decline a randomized clinical trial. JAMA Intern Med 176:175–183. https://doi.org/10.1001/jamainternmed.2015.7148 CrossRefPubMed

44.

Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D et al (2010) Annual high-dose oral vitamin D and falls and fractures in older women. JAMA 303:1815. https://doi.org/10.1001/jama.2010.594 CrossRefPubMed

45.

Guirguis-Blake JM, Michael YL, Perdue LA, Coppola EL, Beil TL (2018) Interventions to prevent falls in older adults: updated evidence report and systematic review for the US preventive services task force. JAMA 98405:1705–1716. https://doi.org/10.1001/jama.2017.21962 CrossRef

46.

Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS et al (2013) Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr 32:375–381. https://doi.org/10.1016/j.clnu.2012.08.014 CrossRefPubMed

47.

Close G, Russell J, Cobley J, Owens D, Wilson G, Gregson W et al (2013) Assessment of vitamin D concentration in non- supplemented professional athletes and healthy adults during the winter months in the UK: implications for skeletal muscle function. J Sports Sci 31:344–353. https://doi.org/10.1080/02640414.2012.733822 CrossRefPubMed

48.

Hornikx M, Van Remoortel H, Lehouck A, Mathieu C, Maes K, Gayan-Ramirez G et al (2012) Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. Respir Res 13:84. https://doi.org/10.1186/1465-9921-13-84 CrossRefPubMedPubMedCentral

49.

Wyon MA, Wolman R, Nevill AM, Cloak R, Metsios GS, Gould D et al (2016) Acute effects of vitamin D 3 supplementation on muscle strength in Judoka athletes: a randomized placebo-controlled double. -blind Trial 26:279–284

50.

Brett NR, Parks CA, Lavery P, Agellon S, Vanstone CA, Kaufmann M et al (2018) Vitamin D status and functional health outcomes in children aged 2–8 y: A 6-mo vitamin D randomized controlled trial. Am J Clin Nutr 107:355–364. https://doi.org/10.1093/ajcn/nqx062 CrossRefPubMed

51.

El-Hajj Fuleihan G, Nabulsi M, Tamim H, Maalouf J, Salamoun M, Khalife H et al (2006) Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial. J Clin Endocrinol Metab 91:405–412. https://doi.org/10.1210/jc.2005-1436 CrossRefPubMed

52.

Manios Y, Moschonis G, Koutsikas K, Papoutsou S, Petraki I, Bellou E et al (2009) Changes in body composition following a dietary and lifestyle intervention trial: the postmenopausal health study. Maturitas 62:58–65. https://doi.org/10.1016/j.maturitas.2008.11.005 CrossRefPubMed

Title: Effects of Vitamin D3 Supplementation on Muscle Strength, Mass, and Physical Performance in Women with Vitamin D Insufficiency: A Randomized Placebo-Controlled Trial
Authors: Lise Sofie Bislev
Lene Langagergaard Rødbro
Lars Rolighed
Tanja Sikjaer
Lars Rejnmark
Publication date: 01-11-2018
Publisher: Springer US
Published in: Calcified Tissue International / Issue 5/2018
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-018-0443-z

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Effects of Vitamin D3 Supplementation on Muscle Strength, Mass, and Physical Performance in Women with Vitamin D Insufficiency: A Randomized Placebo-Controlled Trial

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