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Calcified Tissue International
Published in: Calcified Tissue International 1/2016

01-07-2016 | Review

Implications of the Interaction Between miRNAs and Autophagy in Osteoporosis

Authors: Gengyang Shen, Hui Ren, Ting Qiu, De Liang, Bo Xie, Zhida Zhang, Zhensong Yao, Zhidong Yang, Xiaobing Jiang

Published in: Calcified Tissue International | Issue 1/2016

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Abstract

Imbalances between bone formation and resorption are the primary cause of osteoporosis. However, currently, a detailed molecular mechanism of osteoporosis is not available. Autophagy is the conserved process characterized by degrading and recycling aggregated proteins, intracellular pathogens, and damaged organelles. MicroRNAs (miRNAs) are novel regulatory factors that play important roles in numerous cellular processes, including autophagy, through the posttranscriptional regulation of gene expression. Conversely, autophagy plays a role in the regulation of miRNA homeostasis. Recent advances have revealed that both autophagy and miRNAs are involved in the maintenance of bone homoeostasis, whereas the role of the interaction of miRNAs with autophagy in osteoporosis remains unclear. In this paper, we review previous reports on autophagy, miRNAs, and their interaction in osteoporosis.
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Metadata
Title
Implications of the Interaction Between miRNAs and Autophagy in Osteoporosis
Authors
Gengyang Shen
Hui Ren
Ting Qiu
De Liang
Bo Xie
Zhida Zhang
Zhensong Yao
Zhidong Yang
Xiaobing Jiang
Publication date
01-07-2016
Publisher
Springer US
Published in
Calcified Tissue International / Issue 1/2016
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-016-0122-x

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Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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