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01-05-2013 | Letter to The Editor

Intermittent High Doses of Vitamin D: A Need for Further Studies?

Authors: Salvatore Minisola, Luciano Colangelo, Mirella Cilli, Cristiana Cipriani, Jessica Pepe, Elisabetta Romagnoli

Published in: Calcified Tissue International | Issue 5/2013

Excerpt

It was with interest that we read the paper by Sanders et al. [1] enlightening the harmful effects of the administration of huge doses of vitamin D. However, we believe that some points need clarification. …

Sanders KM, Nicholson GC, Ebeling PR (2013) Is high dose vitamin D harmful? Calcif Tissue Int 92:191–206PubMedCrossRef

Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D et al (2010) Annual high-dose oral vitamin D and falls and fractures in older women. A randomized controlled trial. JAMA 303:1815–1822PubMedCrossRef

Smith H, Anderson F, Raphael H, Maslin P, Crozier S, Cooper C (2007) Effect of annual intramuscular vitamin D on fracture risk in elderly men and women—a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology 46:1815–1822

Vieth R (2011) The pharmacology of vitamin D. In: Feldman D, Pike J, Adams J (eds) Vitamin D. Academic Press, London, pp 1041–1066CrossRef

Cipriani C, Romagnoli E, Scillitani A, Chiodini I, Clerico R, Carnevale V et al (2010) Effect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: a prospective intervention study. J Clin Endocrinol Metab 95:4771–4777PubMedCrossRef

Romagnoli E, Mascia ML, Cipriani C, Fassino V, Mazzei F, D’Erasmo E et al (2008) Short- and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D₂) or cholecalciferol (vitamin D₃) in the elderly. J Clin Endocrinol Metab 93:3015–3020PubMedCrossRef

Title: Intermittent High Doses of Vitamin D: A Need for Further Studies?
Authors: Salvatore Minisola
Luciano Colangelo
Mirella Cilli
Cristiana Cipriani
Jessica Pepe
Elisabetta Romagnoli
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Calcified Tissue International / Issue 5/2013
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI: https://doi.org/10.1007/s00223-013-9714-x

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