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Published in:

01-12-2014 | Review Article

Vitamin D and skeletal health in infancy and childhood

Authors: R. J. Moon, N. C. Harvey, J. H. Davies, C. Cooper

Published in: Osteoporosis International | Issue 12/2014

Abstract

During growth, severe vitamin D deficiency in childhood can result in symptomatic hypocalcaemia and rickets. Despite the suggestion from some studies of a secular increase in the incidence of rickets, this observation may be driven more by changes in population demographics than a true alteration to age, sex and ethnicity-specific incidence rates; indeed, rickets remains uncommon overall and is rarely seen in fair-skinned children. Additionally, the impact of less severe vitamin D deficiency and insufficiency has received much interest in recent years, and in this review, we consider the evidence relating vitamin D status to fracture risk and bone mineral density (BMD) in childhood and adolescence. We conclude that there is insufficient evidence to support the suggestion that low serum 25-hydroxyvitamin D [25(OH)D] increases childhood fracture risk. Overall, the relationship between 25(OH)D and BMD is inconsistent across studies and across skeletal sites within the same study; however, there is evidence to suggest that vitamin D supplementation in children with the lowest levels of 25(OH)D might improve BMD. High-quality randomised trials are now required to confirm this benefit.

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Title: Vitamin D and skeletal health in infancy and childhood
Authors: R. J. Moon
N. C. Harvey
J. H. Davies
C. Cooper
Publication date: 01-12-2014
Publisher: Springer London
Published in: Osteoporosis International / Issue 12/2014
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-014-2783-5

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Springer Medicine

Vitamin D and skeletal health in infancy and childhood

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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