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01-12-2012 | Original Article

Burden of non-hip, non-vertebral fractures on quality of life in postmenopausal women

The Global Longitudinal study of Osteoporosis in Women (GLOW)

Authors: C. Roux, A. Wyman, F. H. Hooven, S. H. Gehlbach, J. D. Adachi, R. D. Chapurlat, J. E. Compston, C. Cooper, A. Díez-Pérez, S. L. Greenspan, A. Z. LaCroix, J. C. Netelenbos, J. Pfeilschifter, M. Rossini, K. G. Saag, P. N. Sambrook, S. Silverman, E. S. Siris, N. B. Watts, S. Boonen, for the GLOW investigators

Published in: Osteoporosis International | Issue 12/2012

Abstract

Summary

Among 50,461 postmenopausal women, 1,822 fractures occurred (57% minor non-hip, non-vertebral [NHNV], 26% major NHNV, 10% spine, 7% hip) over 1 year. Spine fractures had the greatest detrimental effect on EQ-5D, followed by major NHNV and hip fractures. Decreases in physical function and health status were greatest for spine or hip fractures.

Introduction

There is growing evidence that NHNV fractures result in substantial morbidity and healthcare costs. The aim of this prospective study was to assess the effect of these NHNV fractures on quality of life.

Methods

We analyzed the 1-year incidences of hip, spine, major NHNV (pelvis/leg, shoulder/arm) and minor NHNV (wrist/hand, ankle/foot, rib/clavicle) fractures among women from the Global Longitudinal study of Osteoporosis in Women (GLOW). Health-related quality of life (HRQL) was analyzed using the EuroQol EQ-5D tool and the SF-36 health survey.

Results

Among 50,461 women analyzed, there were 1,822 fractures (57% minor NHNV, 26% major NHNV, 10% spine, 7% hip) over 1 year. Spine fractures had the greatest detrimental effect on EQ-5D summary scores, followed by major NHNV and hip fractures. The number of women with mobility problems increased most for those with major NHNV and spine fractures (both +8%); spine fractures were associated with the largest increases in problems with self care (+11%), activities (+14%), and pain/discomfort (+12%). Decreases in physical function and health status were greatest for those with spine or hip fractures. Multivariable modeling found that EQ-5D reduction was greatest for spine fractures, followed by hip and major/minor NHNV. Statistically significant reductions in SF-36 physical function were found for spine fractures, and were borderline significant for major NHNV fractures.

Conclusion

This prospective study shows that NHNV fractures have a detrimental effect on HRQL. Efforts to optimize the care of osteoporosis patients should include the prevention of NHNV fractures.

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Title: Burden of non-hip, non-vertebral fractures on quality of life in postmenopausal women
The Global Longitudinal study of Osteoporosis in Women (GLOW)
Authors: C. Roux
A. Wyman
F. H. Hooven
S. H. Gehlbach
J. D. Adachi
R. D. Chapurlat
J. E. Compston
C. Cooper
A. Díez-Pérez
S. L. Greenspan
A. Z. LaCroix
J. C. Netelenbos
J. Pfeilschifter
M. Rossini
K. G. Saag
P. N. Sambrook
S. Silverman
E. S. Siris
N. B. Watts
S. Boonen
for the GLOW investigators
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 12/2012
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-012-1935-8

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Burden of non-hip, non-vertebral fractures on quality of life in postmenopausal women

The Global Longitudinal study of Osteoporosis in Women (GLOW)

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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