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Published in: Osteoporosis International 6/2009

01-06-2009 | Bone Quality Seminars: Ultrastructure

Influence of remodeling on the mineralization of bone tissue

Authors: G. Boivin, D. Farlay, Y. Bala, A. Doublier, P. J. Meunier, P. D. Delmas

Published in: Osteoporosis International | Issue 6/2009

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Excerpt

To better understand the mechanisms of action of therapies that reduce the risk of fracture, increase bone mineral density, or change the biochemical markers of remodeling, it is necessary not only to analyze their tissue and cellular effects on bone remodeling, bone mass, and microarchitecture but also to discuss their influence on bone mineralization, one of the major parameters reflecting bone quality [1]. …
Literature
1.
go back to reference Seeman E, Delmas PD (2006) Bone quality—the material and structural basis of bone strength and fragility. N Engl J Med 354(21):2250–2261PubMedCrossRef Seeman E, Delmas PD (2006) Bone quality—the material and structural basis of bone strength and fragility. N Engl J Med 354(21):2250–2261PubMedCrossRef
2.
go back to reference Glimcher MJ (1998) The nature of the mineral phase in bone. In: Glimcher MJ (ed) Metabolic bone disease. Academic, San Diego, pp 23–50CrossRef Glimcher MJ (1998) The nature of the mineral phase in bone. In: Glimcher MJ (ed) Metabolic bone disease. Academic, San Diego, pp 23–50CrossRef
3.
go back to reference Boivin G, Meunier PJ (2002) The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography. Calcif Tissue Int 70:503–511PubMedCrossRef Boivin G, Meunier PJ (2002) The degree of mineralization of bone tissue measured by computerized quantitative contact microradiography. Calcif Tissue Int 70:503–511PubMedCrossRef
4.
go back to reference Boivin G, Bala Y, Doublier A, Farlay D, Ste-Marie LG, Meunier PJ, Delmas PD (2008) The role of mineralization and organic matrix in the microhardness of bone tissue from controls and osteoporotic patients. Bone 43:532–538PubMedCrossRef Boivin G, Bala Y, Doublier A, Farlay D, Ste-Marie LG, Meunier PJ, Delmas PD (2008) The role of mineralization and organic matrix in the microhardness of bone tissue from controls and osteoporotic patients. Bone 43:532–538PubMedCrossRef
5.
go back to reference Boivin G, Meunier PJ (2003) Methodological considerations in measurement of bone mineral content. Osteoporos Int 14(suppl 5):22–28CrossRef Boivin G, Meunier PJ (2003) Methodological considerations in measurement of bone mineral content. Osteoporos Int 14(suppl 5):22–28CrossRef
6.
go back to reference Nuzzo S, Peyrin F, Cloetens P, Bachurel J, Boivin G (2002) Quantification of the degree of mineralization of bone in three dimension using synchrotron radiation microtomography. Med Phys 29:2672–2681PubMedCrossRef Nuzzo S, Peyrin F, Cloetens P, Bachurel J, Boivin G (2002) Quantification of the degree of mineralization of bone in three dimension using synchrotron radiation microtomography. Med Phys 29:2672–2681PubMedCrossRef
7.
go back to reference Bala Y, Farlay D, Simi C, Meunier PJ, Delmas PD, Boivin G (2007) Time sequence of secondary mineralization and microhardness of bone in an ewe model. J Bone Miner Res 22(suppl.1):S134 Bala Y, Farlay D, Simi C, Meunier PJ, Delmas PD, Boivin G (2007) Time sequence of secondary mineralization and microhardness of bone in an ewe model. J Bone Miner Res 22(suppl.1):S134
8.
go back to reference Currey JD (1975) The effect of strain rate, reconstruction and mineral content on some mechanical properties of bovine bone. J Biomech 8:81–86PubMedCrossRef Currey JD (1975) The effect of strain rate, reconstruction and mineral content on some mechanical properties of bovine bone. J Biomech 8:81–86PubMedCrossRef
9.
go back to reference Follet H, Boivin G, Rumelhart C, Meunier PJ (2004) The degree of mineralization is a determinant of bone strength. A study on human calcaneus. Bone 34:783–789PubMedCrossRef Follet H, Boivin G, Rumelhart C, Meunier PJ (2004) The degree of mineralization is a determinant of bone strength. A study on human calcaneus. Bone 34:783–789PubMedCrossRef
10.
go back to reference Roschger P, Gupta HS, Berzlanovich A, Ittner G, Dempster DW, Fratzl P, Cosman F, Parisien M, Lindsay R, Nieves JW, Klaushofer K (2003) Constant mineralization density distribution in cancellous human bone. Bone 32:316–323PubMedCrossRef Roschger P, Gupta HS, Berzlanovich A, Ittner G, Dempster DW, Fratzl P, Cosman F, Parisien M, Lindsay R, Nieves JW, Klaushofer K (2003) Constant mineralization density distribution in cancellous human bone. Bone 32:316–323PubMedCrossRef
11.
go back to reference Misof BM, Roschger P, Cosman F, Kurland E, Tesch W, Messmer P, Dempster D, Nieves J, Shane E, Fratzl P, Klaushofer K, Bilezikian J, Lindsay R (2003) Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. J Clin Endocrinol Metab 88:1150–1156PubMedCrossRef Misof BM, Roschger P, Cosman F, Kurland E, Tesch W, Messmer P, Dempster D, Nieves J, Shane E, Fratzl P, Klaushofer K, Bilezikian J, Lindsay R (2003) Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. J Clin Endocrinol Metab 88:1150–1156PubMedCrossRef
12.
go back to reference Arlot ME, Meunier PJ, Boivin G et al (2005) Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters. J Bone Miner Res 20:1244–1253PubMedCrossRef Arlot ME, Meunier PJ, Boivin G et al (2005) Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters. J Bone Miner Res 20:1244–1253PubMedCrossRef
13.
go back to reference Boivin G, Chavassieux PM, Santora AC, Yates J, Meunier PJ (2000) Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone 27:687–694PubMedCrossRef Boivin G, Chavassieux PM, Santora AC, Yates J, Meunier PJ (2000) Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone 27:687–694PubMedCrossRef
14.
go back to reference Boivin G, Lips P, Ott SM, Harper KD, Sarkar S, Pinette KV, Meunier PJ (2003) Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J Clin Endocrinol Metab 88:4199–4205PubMedCrossRef Boivin G, Lips P, Ott SM, Harper KD, Sarkar S, Pinette KV, Meunier PJ (2003) Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J Clin Endocrinol Metab 88:4199–4205PubMedCrossRef
15.
go back to reference Boivin G, Vedi S, Purdie DW, Compston JE, Meunier PJ (2005) Influence of conventional and high doses of estrogen on the degree of mineralisation of bone tissue: a quantitative microradiographic analysis in postmenopausal women. Bone 36:562–567PubMedCrossRef Boivin G, Vedi S, Purdie DW, Compston JE, Meunier PJ (2005) Influence of conventional and high doses of estrogen on the degree of mineralisation of bone tissue: a quantitative microradiographic analysis in postmenopausal women. Bone 36:562–567PubMedCrossRef
16.
go back to reference Borah B, Ritman EL, Dufresne TE, Jorgensen SM, Liu S, Sacha J, Phipps RJ, Turner RT (2005) The effects of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnover. Bone 37:1–9PubMedCrossRef Borah B, Ritman EL, Dufresne TE, Jorgensen SM, Liu S, Sacha J, Phipps RJ, Turner RT (2005) The effects of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnover. Bone 37:1–9PubMedCrossRef
17.
go back to reference Marie PJ, Ammann P, Boivin G, Rey C (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69:121–129PubMedCrossRef Marie PJ, Ammann P, Boivin G, Rey C (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69:121–129PubMedCrossRef
18.
go back to reference Farlay D, Boivin G, Panczer G, Lalande A, Meunier PJ (2005) Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone. J Bone Miner Res 20:1569–1578PubMedCrossRef Farlay D, Boivin G, Panczer G, Lalande A, Meunier PJ (2005) Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone. J Bone Miner Res 20:1569–1578PubMedCrossRef
19.
go back to reference Meunier PJ, Roux C, Seeman E et al (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350:459–468PubMedCrossRef Meunier PJ, Roux C, Seeman E et al (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350:459–468PubMedCrossRef
20.
go back to reference Reginster JY, Seeman E, De Vernejoul MC et al (2005) Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90:2816–2822PubMedCrossRef Reginster JY, Seeman E, De Vernejoul MC et al (2005) Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: treatment of peripheral osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90:2816–2822PubMedCrossRef
21.
go back to reference Boivin G, Farlay D, Simi C, Meunier PJ (2006) Bone strontium distribution and degree of mineralization of bone after 2 and 3 years of treatment with strontium ranelate in postmenopausal osteoporotic women. Calcif Tissue Int 78(Suppl. 1):36–37 Boivin G, Farlay D, Simi C, Meunier PJ (2006) Bone strontium distribution and degree of mineralization of bone after 2 and 3 years of treatment with strontium ranelate in postmenopausal osteoporotic women. Calcif Tissue Int 78(Suppl. 1):36–37
22.
go back to reference Arlot ME, Jiang Y, Genant HK, Zhao J, Burt-Pichat B, Roux JP, Delmas PD, Meunier PJ (2008) Histomorphometric and µ-CT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J Bone Miner Res 23:215–222PubMedCrossRef Arlot ME, Jiang Y, Genant HK, Zhao J, Burt-Pichat B, Roux JP, Delmas PD, Meunier PJ (2008) Histomorphometric and µ-CT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J Bone Miner Res 23:215–222PubMedCrossRef
Metadata
Title
Influence of remodeling on the mineralization of bone tissue
Authors
G. Boivin
D. Farlay
Y. Bala
A. Doublier
P. J. Meunier
P. D. Delmas
Publication date
01-06-2009
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 6/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-009-0861-x

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