Skip to main content
Top
Published in: Osteoporosis International 12/2007

01-12-2007 | Original Article

Successful direct intervention for osteoporosis in patients with minimal trauma fractures

Authors: I. Kuo, C. Ong, L. Simmons, D. Bliuc, J. Eisman, J. Center

Published in: Osteoporosis International | Issue 12/2007

Login to get access

Abstract

Summary

In this study, we offered osteoporosis investigation and treatment directly to patients at out-patient fracture clinics shortly after they sustained minimal trauma fractures. We achieved long-term compliance to the recommended investigation and treatment in 80% of patients. This approach is much more successful than previous interventions.

Introduction

Osteoporosis remains under-treated in minimal-trauma fracture subjects. The aim of this study was to determine if direct intervention at orthopaedic fracture clinics would improve post-fracture management in these subjects.

Methods

From March 2004 to March 2006, 155 consecutive minimal-trauma fracture subjects (mean age 64.0 ± 17.6) attending fracture clinics at St. Vincent’s Hospital, Sydney, had a specific medical assessment, following which they were recommended BMD and laboratory testing. Treatment recommendations were given after review of investigations with further follow-up at a median of 8.6 months following therapy. Comparison of outcomes was made with a similar group of patients given written information 2 years prior.

Results

At baseline, 47% of patients had prior fractures, but only 26% had had BMD screening. Twenty-one percent were on anti-resorptive therapy, and 15% were on calcium/vitamin D. Following intervention, 83% had a BMD and of these, 68% had a T-score < −1.0. Of treatment naïve patients, 44% were recommended anti-resorptive therapy and 56% were recommended calcium/vitamin D. Compliance was 80% for anti-resorptive and 76% for calcium/vitamin D. Female gender and lower BMD were predictors of compliance.

Conclusion

Compared with information-based intervention, direct intervention improved management two to fivefold, maintaining long-term treatment in 90% of osteoporotic and 73% of osteopenic subjects requiring therapy.
Literature
1.
go back to reference Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7:407–413PubMedCrossRef Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7:407–413PubMedCrossRef
2.
go back to reference Johnell O, Kanis JA (2004) An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos Int 15:897–902PubMedCrossRef Johnell O, Kanis JA (2004) An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos Int 15:897–902PubMedCrossRef
3.
go back to reference Burge R, Dawson-Hughes B, Solomon DH et al (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res 22:465–475PubMedCrossRef Burge R, Dawson-Hughes B, Solomon DH et al (2007) Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res 22:465–475PubMedCrossRef
4.
go back to reference Dolan P, Torgerson DJ (1998) The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int 8:611–617PubMedCrossRef Dolan P, Torgerson DJ (1998) The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int 8:611–617PubMedCrossRef
5.
go back to reference Access Economics (2001) The burden of brittle bones: costing osteoporosis in Australia Access Economics (2001) The burden of brittle bones: costing osteoporosis in Australia
6.
go back to reference Brenneman SK, Barrett-Connor E, Sajjan S et al (2006) Impact of recent fracture on health-related quality of life in postmenopausal women. J Bone Miner Res 21:809–816PubMedCrossRef Brenneman SK, Barrett-Connor E, Sajjan S et al (2006) Impact of recent fracture on health-related quality of life in postmenopausal women. J Bone Miner Res 21:809–816PubMedCrossRef
7.
go back to reference Center JR, Nguyen TV, Schneider D et al (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878–882PubMedCrossRef Center JR, Nguyen TV, Schneider D et al (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878–882PubMedCrossRef
8.
go back to reference Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733PubMedCrossRef Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733PubMedCrossRef
9.
go back to reference Guyatt GH, Cranney A, Griffith L et al (2002) Summary of meta-analyses of therapies for postmenopausal osteoporosis and the relationship between bone density and fractures. Endocrinol Metab Clin North Am 31:659–679, xiiPubMedCrossRef Guyatt GH, Cranney A, Griffith L et al (2002) Summary of meta-analyses of therapies for postmenopausal osteoporosis and the relationship between bone density and fractures. Endocrinol Metab Clin North Am 31:659–679, xiiPubMedCrossRef
10.
go back to reference Sawka AM, Papaioannou A, Adachi JD et al (2005) Does alendronate reduce the risk of fracture in men? A meta-analysis incorporating prior knowledge of anti-fracture efficacy in women. BMC Musculoskelet Disord 6:39PubMedCrossRef Sawka AM, Papaioannou A, Adachi JD et al (2005) Does alendronate reduce the risk of fracture in men? A meta-analysis incorporating prior knowledge of anti-fracture efficacy in women. BMC Musculoskelet Disord 6:39PubMedCrossRef
11.
go back to reference Bliuc D, Ong CR, Eisman JA et al (2005) Barriers to effective management of osteoporosis in moderate and minimal trauma fractures: a prospective study. Osteoporos Int 16:977–982PubMedCrossRef Bliuc D, Ong CR, Eisman JA et al (2005) Barriers to effective management of osteoporosis in moderate and minimal trauma fractures: a prospective study. Osteoporos Int 16:977–982PubMedCrossRef
12.
go back to reference Brankin E, Mitchell C, Munro R (2005) Closing the osteoporosis management gap in primary care: a secondary prevention of fracture programme. Curr Med Res Opin 21:475–482PubMedCrossRef Brankin E, Mitchell C, Munro R (2005) Closing the osteoporosis management gap in primary care: a secondary prevention of fracture programme. Curr Med Res Opin 21:475–482PubMedCrossRef
13.
go back to reference Eisman J, Clapham S, Kehoe L (2004) Osteoporosis prevalence and levels of treatment in primary care: the Australian BoneCare Study. J Bone Miner Res 19:1969–1975PubMedCrossRef Eisman J, Clapham S, Kehoe L (2004) Osteoporosis prevalence and levels of treatment in primary care: the Australian BoneCare Study. J Bone Miner Res 19:1969–1975PubMedCrossRef
14.
go back to reference McNearney TA, Shepherd AJ, Chhabra A et al (2006) Primary care house staff attitudes toward osteoporosis management. South Med J 99:461–466PubMedCrossRef McNearney TA, Shepherd AJ, Chhabra A et al (2006) Primary care house staff attitudes toward osteoporosis management. South Med J 99:461–466PubMedCrossRef
15.
go back to reference Simonelli C, Killeen K, Mehle S et al (2002) Barriers to osteoporosis identification and treatment among primary care physicians and orthopedic surgeons. Mayo Clin Proc 77:334–338PubMed Simonelli C, Killeen K, Mehle S et al (2002) Barriers to osteoporosis identification and treatment among primary care physicians and orthopedic surgeons. Mayo Clin Proc 77:334–338PubMed
16.
go back to reference Skedros JG, Holyoak JD, Pitts TC (2006) Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. J Bone Joint Surg Am 88:18–24PubMedCrossRef Skedros JG, Holyoak JD, Pitts TC (2006) Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. J Bone Joint Surg Am 88:18–24PubMedCrossRef
17.
go back to reference Borgstrom F, Carlsson A, Sintonen H et al (2006) The cost-effectiveness of risedronate in the treatment of osteoporosis: an international perspective. Osteoporos Int 17:996–1007PubMedCrossRef Borgstrom F, Carlsson A, Sintonen H et al (2006) The cost-effectiveness of risedronate in the treatment of osteoporosis: an international perspective. Osteoporos Int 17:996–1007PubMedCrossRef
18.
go back to reference Brecht JG, Kruse HP, Mohrke W et al (2004) Health-economic comparison of three recommended drugs for the treatment of osteoporosis. Int J Clin Pharmacol Res 24:1–10PubMed Brecht JG, Kruse HP, Mohrke W et al (2004) Health-economic comparison of three recommended drugs for the treatment of osteoporosis. Int J Clin Pharmacol Res 24:1–10PubMed
19.
go back to reference Cryer B, Bauer DC (2002) Oral bisphosphonates and upper gastrointestinal tract problems: what is the evidence? Mayo Clin Proc 77:1031–1043PubMedCrossRef Cryer B, Bauer DC (2002) Oral bisphosphonates and upper gastrointestinal tract problems: what is the evidence? Mayo Clin Proc 77:1031–1043PubMedCrossRef
20.
go back to reference Liberman UA (2006) Long-term safety of bisphosphonate therapy for osteoporosis : a review of the evidence. Drugs Aging 23:289–298PubMedCrossRef Liberman UA (2006) Long-term safety of bisphosphonate therapy for osteoporosis : a review of the evidence. Drugs Aging 23:289–298PubMedCrossRef
21.
go back to reference Jaglal SB, Cameron C, Hawker GA et al (2006) Development of an integrated-care delivery model for post-fracture care in Ontario, Canada. Osteoporos Int 17:1337–1345PubMedCrossRef Jaglal SB, Cameron C, Hawker GA et al (2006) Development of an integrated-care delivery model for post-fracture care in Ontario, Canada. Osteoporos Int 17:1337–1345PubMedCrossRef
22.
go back to reference Meadows LM, Mrkonjic LA, O’Brien MD et al (2006) The importance of communication in secondary fragility fracture treatment and prevention. Osteoporos Int 18:159–166 Meadows LM, Mrkonjic LA, O’Brien MD et al (2006) The importance of communication in secondary fragility fracture treatment and prevention. Osteoporos Int 18:159–166
23.
go back to reference Bliuc D, Eisman JA, Center JR (2006) A randomized study of two different information-based interventions on the management of osteoporosis in minimal and moderate trauma fractures. Osteoporos Int 17:1309–1317PubMedCrossRef Bliuc D, Eisman JA, Center JR (2006) A randomized study of two different information-based interventions on the management of osteoporosis in minimal and moderate trauma fractures. Osteoporos Int 17:1309–1317PubMedCrossRef
24.
go back to reference Hawker G, Ridout R, Ricupero M et al (2003) The impact of a simple fracture clinic intervention in improving the diagnosis and treatment of osteoporosis in fragility fracture patients. Osteoporos Int 14:171–178PubMedCrossRef Hawker G, Ridout R, Ricupero M et al (2003) The impact of a simple fracture clinic intervention in improving the diagnosis and treatment of osteoporosis in fragility fracture patients. Osteoporos Int 14:171–178PubMedCrossRef
25.
go back to reference Dreinhofer KE, Anderson M, Feron JM et al (2005) Multinational survey of osteoporotic fracture management. Osteoporos Int 16(Suppl 2):S44–S53PubMedCrossRef Dreinhofer KE, Anderson M, Feron JM et al (2005) Multinational survey of osteoporotic fracture management. Osteoporos Int 16(Suppl 2):S44–S53PubMedCrossRef
26.
go back to reference Giangregorio L, Papaioannou A, Cranney A et al (2006) Fragility fractures and the osteoporosis care gap: an international phenomenon. Semin Arthritis Rheum 35:293–305PubMedCrossRef Giangregorio L, Papaioannou A, Cranney A et al (2006) Fragility fractures and the osteoporosis care gap: an international phenomenon. Semin Arthritis Rheum 35:293–305PubMedCrossRef
27.
go back to reference Port L, Center J, Briffa NK et al (2003) Osteoporotic fracture: missed opportunity for intervention. Osteoporos Int 14:780–784PubMedCrossRef Port L, Center J, Briffa NK et al (2003) Osteoporotic fracture: missed opportunity for intervention. Osteoporos Int 14:780–784PubMedCrossRef
28.
go back to reference Smith MD, Ross W, Ahern MJ (2001) Missing a therapeutic window of opportunity: an audit of patients attending a tertiary teaching hospital with potentially osteoporotic hip and wrist fractures. J Rheumatol 28:2504–2508PubMed Smith MD, Ross W, Ahern MJ (2001) Missing a therapeutic window of opportunity: an audit of patients attending a tertiary teaching hospital with potentially osteoporotic hip and wrist fractures. J Rheumatol 28:2504–2508PubMed
29.
go back to reference Skedros JG (2004) The orthopaedic surgeon’s role in diagnosing and treating patients with osteoporotic fractures: standing discharge orders may be the solution for timely medical care. Osteoporos Int 15:405–410PubMedCrossRef Skedros JG (2004) The orthopaedic surgeon’s role in diagnosing and treating patients with osteoporotic fractures: standing discharge orders may be the solution for timely medical care. Osteoporos Int 15:405–410PubMedCrossRef
30.
go back to reference Bouxsein ML, Kaufman J, Tosi L et al (2004) Recommendations for optimal care of the fragility fracture patient to reduce the risk of future fracture. J Am Acad Orthop Surg 12:385–395PubMed Bouxsein ML, Kaufman J, Tosi L et al (2004) Recommendations for optimal care of the fragility fracture patient to reduce the risk of future fracture. J Am Acad Orthop Surg 12:385–395PubMed
31.
go back to reference Prasad N, Sunderamoorthy D, Martin J et al (2006) Secondary prevention of fragility fractures: are we following the guidelines? Closing the audit loop. Ann R Coll Surg Engl 88:470–474PubMedCrossRef Prasad N, Sunderamoorthy D, Martin J et al (2006) Secondary prevention of fragility fractures: are we following the guidelines? Closing the audit loop. Ann R Coll Surg Engl 88:470–474PubMedCrossRef
32.
go back to reference Gardner MJ, Brophy RH, Demetrakopoulos D et al (2005) Interventions to improve osteoporosis treatment following hip fracture. A prospective, randomized trial. J Bone Joint Surg Am 87:3–7PubMedCrossRef Gardner MJ, Brophy RH, Demetrakopoulos D et al (2005) Interventions to improve osteoporosis treatment following hip fracture. A prospective, randomized trial. J Bone Joint Surg Am 87:3–7PubMedCrossRef
33.
go back to reference Feldstein A, Elmer PJ, Smith DH et al (2006) Electronic medical record reminder improves osteoporosis management after a fracture: a randomized, controlled trial. J Am Geriatr Soc 54:450–457PubMedCrossRef Feldstein A, Elmer PJ, Smith DH et al (2006) Electronic medical record reminder improves osteoporosis management after a fracture: a randomized, controlled trial. J Am Geriatr Soc 54:450–457PubMedCrossRef
34.
go back to reference Weycker D, Macarios D, Edelsberg J et al (2006) Compliance with drug therapy for postmenopausal osteoporosis. Osteoporos Int 17:1645–1652PubMedCrossRef Weycker D, Macarios D, Edelsberg J et al (2006) Compliance with drug therapy for postmenopausal osteoporosis. Osteoporos Int 17:1645–1652PubMedCrossRef
Metadata
Title
Successful direct intervention for osteoporosis in patients with minimal trauma fractures
Authors
I. Kuo
C. Ong
L. Simmons
D. Bliuc
J. Eisman
J. Center
Publication date
01-12-2007
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 12/2007
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-007-0418-9

Other articles of this Issue 12/2007

Osteoporosis International 12/2007 Go to the issue