Skip to main content
Top
Published in: International Urogynecology Journal 1/2020

Open Access 01-01-2020 | Stress Incontinence | Original Article

Genetic association in female stress urinary incontinence based on proteomic findings: a case-control study

Authors: Theresa Reischer, Sukirthini Balendran-Braun, Sandra Liebmann-Reindl, Berthold Streubel, Wolfgang Umek, Heinz Koelbl, Marianne Koch

Published in: International Urogynecology Journal | Issue 1/2020

Login to get access

Abstract

Introduction and hypothesis

Previous studies have indicated a hereditary component of stress urinary incontinence; however, evidence on candidate genes or single-nucleotide polymorphisms (SNPs) is scarce. We hypothesize a genetic association of female stress urinary incontinence based on significant differences of the urinary and serum proteomic pattern in the identical study population.

Methods

Case-control study of 19 patients and 19 controls. We searched for known SNPs of SUI candidate genes (COL1A1, MMP1, SERPINA5, UMOD) in the database of short genetic variations and PubMed. Genomic DNA was isolated using QIAamp DNA Blood Midi Kit (Qiagen). We performed Sanger sequencing of selected exons and introns.

Results

The rs885786 SNP of the SERPINA5 gene was identified in 15 cases and 10 controls (p = 0.09). The rs6113 SNP of the SERPINA5 gene was present in 4 controls compared to 0 cases (p = 0.105). The rs4293393, rs13333226 and rs13335818 SNPs of the UMOD gene were identified in five cases and two controls (p = 0.20), the rs1800012 SNP of the COL1A1 gene in five cases versus four controls (p = 0.24) and the homozygous rs1799750 SNP of the MMP1 gene in eight cases versus five controls (p = 0.18). The combination of the rs885786 SNP of the SERPINA5 gene and rs179970 SNP of the MMP1 gene was detected in ten cases versus five controls (p = 0.072).

Conclusions

We found nonsignificant trends toward associations of SNPs on the SERPINA5, UMOD and MMP1 gene and SUI.
Appendix
Available only for authorised users
Literature
22.
go back to reference Bender R, Lange S. Adjusting for multiple testing—when and how? J Clin Epidemiol. 2001;54(4):343–9.CrossRef Bender R, Lange S. Adjusting for multiple testing—when and how? J Clin Epidemiol. 2001;54(4):343–9.CrossRef
Metadata
Title
Genetic association in female stress urinary incontinence based on proteomic findings: a case-control study
Authors
Theresa Reischer
Sukirthini Balendran-Braun
Sandra Liebmann-Reindl
Berthold Streubel
Wolfgang Umek
Heinz Koelbl
Marianne Koch
Publication date
01-01-2020
Publisher
Springer International Publishing
Published in
International Urogynecology Journal / Issue 1/2020
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-019-03878-0

Other articles of this Issue 1/2020

International Urogynecology Journal 1/2020 Go to the issue