Skip to main content
Top
Published in: Knee Surgery, Sports Traumatology, Arthroscopy 3/2021

01-03-2021 | Computed Tomography | KNEE

Neutral alignment resulting from tibial vara and opposite femoral valgus is the main morphologic pattern in healthy middle-aged patients: an exploration of a 3D-CT database

Authors: Grégoire Micicoi, Christophe Jacquet, Akash Sharma, Sally LiArno, Ahmad Faizan, Kristian Kley, Sébastien Parratte, Matthieu Ollivier

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 3/2021

Login to get access

Abstract

Purpose

Given the goal of achieving optimal correction and alignment after knee arthroplasty or high tibial osteotomy, literature focusing on the inter-individual variability of the native knee, tibia and femur with regards to the coronal or sagittal alignment is lacking. The aim of this study was to analyse normal angular values in the healthy middle-aged population and determine differences of angular values according to inter-individual features. The first hypothesis was that common morphological patterns may be identified in the healthy middle-aged non-osteoarthritic population. The second hypothesis was that high inter-individual variability exists with regards to gender, ethnicity and alignment phenotype.

Methods

A CT scan-based modelling and analysis system was used to examine the lower limb of 758 normal healthy patients (390 men, 368 women; mean age 58.5 ± 16.4 years) with available data concerning angular values and retrieved from the SOMA database. The hip–knee–ankle angle (HKA), lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), posterior distal femoral angle (PDFA), posterior proximal tibial angle (PPTA) and non weight-bearing joint line convergence angle (nwJLCA) were then measured for each patient. Results were analysed for the entire cohort and based on gender, ethnicity and phenotype.

Results

The mean HKA was 179.4° ± 2.6°, LDFA: 85.8° ± 2.0°, MPTA: 85.6° ± 2.4°, PDFA: 85.2° ± 1.5°, PPTA: 83.8° ± 2.9° and nwJLCA: 1.09° ± 0.9°. Gender was associated with higher LDFA and lower HKA for men. Ethnicity was associated with greater proximal tibial vara and distal femoral valgus for Asian patients. Patients with an overall global varus alignment had more tibia vara and less femoral valgus than patients with an overall valgus alignment.

Conclusion

Even if significant differences were found based on subgroup analysis (gender, ethnicity or phenotype), this study demonstrated that neutral alignment is the main morphological pattern in the healthy middle-aged population. This neutrality is the result from tibia vara compensated by an ipsilateral femoral valgus.

Level of clinical evidence

III, retrospective cohort study.
Literature
1.
go back to reference Banerjee S, Faizan A, Nevelos J, Kreuzer S, Burgkart R, Harwin SF, Mont MA (2014) Innovations in hip arthroplasty three-dimensional modeling and analytical technology (SOMA). Surg Technol Int 24:288–294PubMed Banerjee S, Faizan A, Nevelos J, Kreuzer S, Burgkart R, Harwin SF, Mont MA (2014) Innovations in hip arthroplasty three-dimensional modeling and analytical technology (SOMA). Surg Technol Int 24:288–294PubMed
2.
go back to reference Bellemans J, Colyn W, Vandenneucker H, Victor J (2012) The Chitranjan Ranawat Award: is neutral mechanical alignment normal for all patients? The concept of constitutional varus. Clin Orthop Relat Res 470:45–53CrossRef Bellemans J, Colyn W, Vandenneucker H, Victor J (2012) The Chitranjan Ranawat Award: is neutral mechanical alignment normal for all patients? The concept of constitutional varus. Clin Orthop Relat Res 470:45–53CrossRef
3.
go back to reference Bito H, Takeuchi R, Kumagai K, Aratake M, Saito I, Hayashi R, Sasaki Y, Aota Y, Saito T (2009) A predictive factor for acquiring an ideal lower limb realignment after opening-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 17:382–389CrossRef Bito H, Takeuchi R, Kumagai K, Aratake M, Saito I, Hayashi R, Sasaki Y, Aota Y, Saito T (2009) A predictive factor for acquiring an ideal lower limb realignment after opening-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 17:382–389CrossRef
4.
go back to reference Chao EY, Neluheni EV, Hsu RW, Paley D (1994) Biomechanics of malalignment. Orthop Clin N Am 25:379–386CrossRef Chao EY, Neluheni EV, Hsu RW, Paley D (1994) Biomechanics of malalignment. Orthop Clin N Am 25:379–386CrossRef
5.
go back to reference Cooke D, Scudamore A, Li J, Wyss U, Bryant T, Costigan P (1997) Axial lower-limb alignment: comparison of knee geometry in normal volunteers and osteoarthritis patients. Osteoarthr Cartil 5:39–47CrossRef Cooke D, Scudamore A, Li J, Wyss U, Bryant T, Costigan P (1997) Axial lower-limb alignment: comparison of knee geometry in normal volunteers and osteoarthritis patients. Osteoarthr Cartil 5:39–47CrossRef
6.
go back to reference Hankemeier S, Mommsen P, Krettek C, Jagodzinski M, Brand J, Meyer C, Meller R (2010) Accuracy of high tibial osteotomy: comparison between open- and closed-wedge technique. Knee Surg Sports Traumatol Arthrosc 18:1328–1333CrossRef Hankemeier S, Mommsen P, Krettek C, Jagodzinski M, Brand J, Meyer C, Meller R (2010) Accuracy of high tibial osteotomy: comparison between open- and closed-wedge technique. Knee Surg Sports Traumatol Arthrosc 18:1328–1333CrossRef
7.
go back to reference Hess S, Moser LB, Amsler F, Behrend H, Hirschmann MT (2019) Highly variable coronal tibial and femoral alignment in osteoarthritic knees: a systematic review. Knee Surg Sports Traumatol Arthrosc 27:1368–1377CrossRef Hess S, Moser LB, Amsler F, Behrend H, Hirschmann MT (2019) Highly variable coronal tibial and femoral alignment in osteoarthritic knees: a systematic review. Knee Surg Sports Traumatol Arthrosc 27:1368–1377CrossRef
8.
go back to reference Hirschmann MT, Hess S, Behrend H, Amsler F, Leclercq V, Moser LB (2019) Phenotyping of hip–knee–ankle angle in young non-osteoarthritic knees provides better understanding of native alignment variability. Knee Surg Sports Traumatol Arthrosc 27:1378–1384CrossRef Hirschmann MT, Hess S, Behrend H, Amsler F, Leclercq V, Moser LB (2019) Phenotyping of hip–knee–ankle angle in young non-osteoarthritic knees provides better understanding of native alignment variability. Knee Surg Sports Traumatol Arthrosc 27:1378–1384CrossRef
9.
go back to reference Hirschmann MT, Moser LB, Amsler F, Behrend H, Leclercq V, Hess S (2019) Phenotyping the knee in young non-osteoarthritic knees shows a wide distribution of femoral and tibial coronal alignment. Knee Surg Sports Traumatol Arthrosc 27:1385–1393CrossRef Hirschmann MT, Moser LB, Amsler F, Behrend H, Leclercq V, Hess S (2019) Phenotyping the knee in young non-osteoarthritic knees shows a wide distribution of femoral and tibial coronal alignment. Knee Surg Sports Traumatol Arthrosc 27:1385–1393CrossRef
10.
go back to reference Hirschmann MT, Moser LB, Amsler F, Behrend H, Leclerq V, Hess S (2019) Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients. Knee Surg Sports Traumatol Arthrosc 27:1394–1402CrossRef Hirschmann MT, Moser LB, Amsler F, Behrend H, Leclerq V, Hess S (2019) Functional knee phenotypes: a novel classification for phenotyping the coronal lower limb alignment based on the native alignment in young non-osteoarthritic patients. Knee Surg Sports Traumatol Arthrosc 27:1394–1402CrossRef
11.
go back to reference Hovinga KR, Lerner AL (2009) Anatomic variations between Japanese and Caucasian populations in the healthy young adult knee joint. J Orthop Res 27:1191–1196CrossRef Hovinga KR, Lerner AL (2009) Anatomic variations between Japanese and Caucasian populations in the healthy young adult knee joint. J Orthop Res 27:1191–1196CrossRef
12.
go back to reference Hsu RW, Himeno S, Coventry MB, Chao EY (1990) Normal axial alignment of the lower extremity and load-bearing distribution at the knee. Clin Orthop Relat Res 255:215–227 Hsu RW, Himeno S, Coventry MB, Chao EY (1990) Normal axial alignment of the lower extremity and load-bearing distribution at the knee. Clin Orthop Relat Res 255:215–227
13.
go back to reference Hungerford DS, Krackow KA (1985) Total joint arthroplasty of the knee. Clin Orthop Relat Res 192:23–33 Hungerford DS, Krackow KA (1985) Total joint arthroplasty of the knee. Clin Orthop Relat Res 192:23–33
14.
go back to reference Jabalameli M, Moghimi J, Yeganeh A, Nojomi M (2015) Parameters of lower extremities alignment view in Iranian adult population. Acta Med Iran 53:293–296PubMed Jabalameli M, Moghimi J, Yeganeh A, Nojomi M (2015) Parameters of lower extremities alignment view in Iranian adult population. Acta Med Iran 53:293–296PubMed
15.
go back to reference Jacquet C, Laumonerie P, LiArno S, Faizan A, Sharma A, Dagneaux L, Ollivier M (2019) Contralateral preoperative templating of lower limbs’ mechanical angles is a reasonable option. Knee Surg Sports Traumatol Arthrosc 28:1445–1451CrossRef Jacquet C, Laumonerie P, LiArno S, Faizan A, Sharma A, Dagneaux L, Ollivier M (2019) Contralateral preoperative templating of lower limbs’ mechanical angles is a reasonable option. Knee Surg Sports Traumatol Arthrosc 28:1445–1451CrossRef
16.
go back to reference Jang K-M, Lee J-H, Cho IY, Park B-K, Han S-B (2017) Intraoperative fluoroscopic assessment of limb alignment is a reliable predictor for postoperative limb alignment in biplanar medial opening-wedge high tibial osteotomy. J Arthroplasty 32:756–760CrossRef Jang K-M, Lee J-H, Cho IY, Park B-K, Han S-B (2017) Intraoperative fluoroscopic assessment of limb alignment is a reliable predictor for postoperative limb alignment in biplanar medial opening-wedge high tibial osteotomy. J Arthroplasty 32:756–760CrossRef
17.
go back to reference Lee D-H, Park S-C, Park H-J, Han S-B (2016) Effect of soft tissue laxity of the knee joint on limb alignment correction in open-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 24:3704–3712CrossRef Lee D-H, Park S-C, Park H-J, Han S-B (2016) Effect of soft tissue laxity of the knee joint on limb alignment correction in open-wedge high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc 24:3704–3712CrossRef
18.
go back to reference Leszko F, Hovinga KR, Lerner AL, Komistek RD, Mahfouz MR (2011) In vivo normal knee kinematics: is ethnicity or gender an influencing factor? Clin Orthop Relat Res 469:95–106CrossRef Leszko F, Hovinga KR, Lerner AL, Komistek RD, Mahfouz MR (2011) In vivo normal knee kinematics: is ethnicity or gender an influencing factor? Clin Orthop Relat Res 469:95–106CrossRef
19.
go back to reference Mahfouz M, Abdel Fatah EE, Bowers LS, Scuderi G (2012) Three-dimensional morphology of the knee reveals ethnic differences. Clin Orthop Relat Res 470:172–185CrossRef Mahfouz M, Abdel Fatah EE, Bowers LS, Scuderi G (2012) Three-dimensional morphology of the knee reveals ethnic differences. Clin Orthop Relat Res 470:172–185CrossRef
20.
go back to reference Moreland JR, Bassett LW, Hanker GJ (1987) Radiographic analysis of the axial alignment of the lower extremity. J Bone Jt Surg Am 69:745–749CrossRef Moreland JR, Bassett LW, Hanker GJ (1987) Radiographic analysis of the axial alignment of the lower extremity. J Bone Jt Surg Am 69:745–749CrossRef
21.
go back to reference Moser LB, Hess S, Amsler F, Behrend H, Hirschmann MT (2019) Native non-osteoarthritic knees have a highly variable coronal alignment: a systematic review. Knee Surg Sports Traumatol Arthrosc 27:1359–1367CrossRef Moser LB, Hess S, Amsler F, Behrend H, Hirschmann MT (2019) Native non-osteoarthritic knees have a highly variable coronal alignment: a systematic review. Knee Surg Sports Traumatol Arthrosc 27:1359–1367CrossRef
22.
go back to reference Nakano N, Matsumoto T, Hashimura M, Takayama K, Ishida K, Araki D, Matsushita T, Kuroda R, Kurosaka M (2016) Coronal lower limb alignment in normal knees—a radiographic analysis of 797 normal knee subjects. Knee 23:209–213CrossRef Nakano N, Matsumoto T, Hashimura M, Takayama K, Ishida K, Araki D, Matsushita T, Kuroda R, Kurosaka M (2016) Coronal lower limb alignment in normal knees—a radiographic analysis of 797 normal knee subjects. Knee 23:209–213CrossRef
23.
go back to reference Ritter MA, Davis KE, Meding JB, Pierson JL, Berend ME, Malinzak RA (2011) The effect of alignment and BMI on failure of total knee replacement. Bone Jt Surg Am 93:1588–1596CrossRef Ritter MA, Davis KE, Meding JB, Pierson JL, Berend ME, Malinzak RA (2011) The effect of alignment and BMI on failure of total knee replacement. Bone Jt Surg Am 93:1588–1596CrossRef
24.
go back to reference Sabharwal S, Zhao C (2008) Assessment of lower limb alignment: supine fluoroscopy compared with a standing full-length radiograph. Bone Jt Surg Am 90:43–51CrossRef Sabharwal S, Zhao C (2008) Assessment of lower limb alignment: supine fluoroscopy compared with a standing full-length radiograph. Bone Jt Surg Am 90:43–51CrossRef
25.
go back to reference Schmidt W, LiArno S, Khlopas A, Petersik A, Mont MA (2018) Stryker orthopaedic modeling and analytics (SOMA): a review. Surg Technol Int 32:315–324PubMed Schmidt W, LiArno S, Khlopas A, Petersik A, Mont MA (2018) Stryker orthopaedic modeling and analytics (SOMA): a review. Surg Technol Int 32:315–324PubMed
26.
go back to reference Schröder M, Gottschling H, Reimers N, Hauschild M, Burgkart R (2014) Automated morphometric analysis of the femur on large anatomical databases with highly accurate correspondence detection. Med J 1:15–22 Schröder M, Gottschling H, Reimers N, Hauschild M, Burgkart R (2014) Automated morphometric analysis of the femur on large anatomical databases with highly accurate correspondence detection. Med J 1:15–22
27.
go back to reference Shetty GM, Mullaji A, Bhayde S, Nha KW, Oh HK (2014) Factors contributing to inherent varus alignment of lower limb in normal Asian adults: role of tibial plateau inclination. Knee 21:544–548CrossRef Shetty GM, Mullaji A, Bhayde S, Nha KW, Oh HK (2014) Factors contributing to inherent varus alignment of lower limb in normal Asian adults: role of tibial plateau inclination. Knee 21:544–548CrossRef
28.
go back to reference Tamari K, Tinley P, Briffa K, Aoyagi K (2005) Ethnic-, gender-, and age-related differences in femorotibial angle, femoral antetorsion, and tibiofibular torsion: cross-sectional study among healthy Japanese and Australian Caucasians. Clin Anat 19:59–67CrossRef Tamari K, Tinley P, Briffa K, Aoyagi K (2005) Ethnic-, gender-, and age-related differences in femorotibial angle, femoral antetorsion, and tibiofibular torsion: cross-sectional study among healthy Japanese and Australian Caucasians. Clin Anat 19:59–67CrossRef
29.
go back to reference Tanaka T, Takayama K, Hashimoto S, Kanzaki N, Hayashi S, Kuroda R, Matsumoto T (2017) Radiographic analysis of the lower limbs using the hip–calcaneus line in healthy individuals and in patients with varus knee osteoarthritis. Knee 24:1146–1152CrossRef Tanaka T, Takayama K, Hashimoto S, Kanzaki N, Hayashi S, Kuroda R, Matsumoto T (2017) Radiographic analysis of the lower limbs using the hip–calcaneus line in healthy individuals and in patients with varus knee osteoarthritis. Knee 24:1146–1152CrossRef
30.
go back to reference Tang WM, Zhu YH, Chiu KY (2000) Axial alignment of the lower Extremity in Chinese Adults. Bone Jt Surg Am 82:1603–1608CrossRef Tang WM, Zhu YH, Chiu KY (2000) Axial alignment of the lower Extremity in Chinese Adults. Bone Jt Surg Am 82:1603–1608CrossRef
31.
go back to reference Than P, Szuper K, Somoskeöy S, Warta V, Illés T (2012) Geometrical values of the normal and arthritic hip and knee detected with the EOS imaging system. Int Orthop 36:1291–1297CrossRef Than P, Szuper K, Somoskeöy S, Warta V, Illés T (2012) Geometrical values of the normal and arthritic hip and knee detected with the EOS imaging system. Int Orthop 36:1291–1297CrossRef
32.
go back to reference Thienpont E, Schwab PE, Cornu O, Bellemans J, Victor J (2017) Bone morphotypes of the varus and valgus knee. Arch Orthop Trauma Surg 137:393–400CrossRef Thienpont E, Schwab PE, Cornu O, Bellemans J, Victor J (2017) Bone morphotypes of the varus and valgus knee. Arch Orthop Trauma Surg 137:393–400CrossRef
34.
go back to reference Yazdanpanah O, Mobarakeh MK, Nakhaei M, Baneshi MR (2017) Comparison of double and single leg weight-bearing radiography in determining knee alignment. Arch Bone Jt Surg 5:174–180PubMedPubMedCentral Yazdanpanah O, Mobarakeh MK, Nakhaei M, Baneshi MR (2017) Comparison of double and single leg weight-bearing radiography in determining knee alignment. Arch Bone Jt Surg 5:174–180PubMedPubMedCentral
Metadata
Title
Neutral alignment resulting from tibial vara and opposite femoral valgus is the main morphologic pattern in healthy middle-aged patients: an exploration of a 3D-CT database
Authors
Grégoire Micicoi
Christophe Jacquet
Akash Sharma
Sally LiArno
Ahmad Faizan
Kristian Kley
Sébastien Parratte
Matthieu Ollivier
Publication date
01-03-2021
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 3/2021
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-020-06030-4

Other articles of this Issue 3/2021

Knee Surgery, Sports Traumatology, Arthroscopy 3/2021 Go to the issue