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Knee Surgery, Sports Traumatology, Arthroscopy
Published in: Knee Surgery, Sports Traumatology, Arthroscopy 5/2015

01-05-2015 | Experimental Study

Synovial cytokine expression in ankle osteoarthritis depends on age and stage

Authors: Hagen Schmal, Ralf Henkelmann, Alexander T. Mehlhorn, Kilian Reising, Gerrit Bode, Norbert P. Südkamp, Philipp Niemeyer

Published in: Knee Surgery, Sports Traumatology, Arthroscopy | Issue 5/2015

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Abstract

Purpose

Aim of the study was the analysis of cytokine expression in ankle osteoarthritis (OA) hypothesizing age-dependent regulation patterns.

Methods

Forty-nine patients undergoing an arthroscopy of the ankle with different stages of chronic OA were prospectively included in a clinical trial comparing the group <18 years (n = 9, Ø15.1 ± 2.0 years) with the older patients (≥18 years, n = 40, Ø36.5 ± 11.9). Lavage fluids were analysed by ELISA for levels of aggrecan, BMP-2/7, IGF-1/R, bFGF, CD105, MMP-13, and IL-1β. Additionally, clinical parameters and scores (FFI, CFSS, AOFAS) were evaluated and supplemented by radiographic scores [Kellgren–Lawrence Score (KLS) for conventional X-rays, Ankle Osteoarthritis Scoring System (AOSS) for MRI].

Results

In contrast to distribution of gender and BMI (p < 0.005), parameters characterizing the cartilage defect as ICRS grading, size, and duration of symptoms were not dependent on age. The incidence of osteochondritis dissecans (OCD) was higher in the group <18 years (p < 0.006), but the average degree of OCD grading was not different. KLS and AOSS were significantly higher in the group ≥18 years (p < 0.02). Correlating with the higher degree of OA in the elderly, clinical function measured by FFI and AOFAS was statistically significantly worse (p < 0.05). Intra-articular concentrations of aggrecan (3.1-fold), bFGF (8.7-fold), BMP-7 (2.7-fold), and CD105 (1.5-fold) were statistically significantly higher in the group ≥18 years (p < 0.03).

Conclusions

Confirming the hypothesis, increased synovial levels of aggrecan, bFGF, BMP-7, and CD105 were found in patients over 18 years. This correlated with a higher stage of OA determined by radiographic changes or deteriorated function and may offer starting points for new diagnostics and interventional strategies.

Level of evidence

II.
Literature
1.
Aurich M, Eger W, Rolauffs B, Margulis A, Kuettner KE, Mollenhauer JA, Cole AA (2006) Ankle chondrocytes are more resistant to interleukin-1 than chondrocytes derived from the knee. Orthopade 35:784–790CrossRefPubMed
2.
Berndt AL, Harty M (1959) Transchondral fractures (osteochondritis dissecans) of the talus. J Bone Joint Surg Am 41-A: 988–1020
3.
Bohndorf K (1998) Osteochondritis (osteochondrosis) dissecans: a review and new MRI classification. Eur Radiol 8:103–112CrossRefPubMed
4.
5.
Choi WJ, Choi GW, Kwon H-M, Lee JW (2013) Arthroscopic treatment in mild to moderate osteoarthritis of the ankle. Knee Surg Sports Traumatol Arthrosc 21:1338–1344CrossRefPubMed
6.
7.
Van Dijk CN, Reilingh ML, Zengerink M, van Bergen CJA (2010) Osteochondral defects in the ankle: why painful? Knee Surg Sports Traumatol Arthrosc 18:570–580CrossRefPubMedCentralPubMed
8.
Doria AS, Babyn PS, Lundin B, Kilcoyne RF, Miller S, Rivard GE, Moineddin R, Pettersson H (2006) Reliability and construct validity of the compatible MRI scoring system for evaluation of haemophilic knees and ankles of haemophilic children. Expert MRI working group of the international prophylaxis study group. Haemophilia 12:503–513CrossRefPubMed
9.
Doria AS, Lundin B, Miller S, Kilcoyne R, Dunn A, Thomas S, Rivard G, Moineddin R, Babyn PS (2008) Reliability and construct validity of the compatible MRI scoring system for evaluation of elbows in haemophilic children. Haemophilia 14:303–314CrossRefPubMed
10.
Eger W, Aurich M, Schumacher BL, Mollenhauer J, Kuettner KE, Cole AA (2003) Differences in metabolism of chondrocytes of the knee and ankle joint. Z Orthop Ihre Grenzgeb 141:18–20PubMed
11.
Galat DD, Ackerman DB, Spoon D, Turner NS, Shives TC (2008) Synovial chondromatosis of the foot and ankle. Foot Ankle Int 29:312–317CrossRefPubMed
12.
13.
Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y (2008) Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 67(Suppl 3):75–82CrossRef
14.
Hao D-P, Zhang J-Z, Xu W-J, Wang Z-C, Wang X-N (2011) Pigmented villonodular synovitis of the ankle: radiologic characteristics. J Am Podiatr Med Assoc 101:252–258CrossRefPubMed
15.
16.
Hashimoto S, Rai MF, Janiszak KL, Cheverud JM, Sandell LJ (2012) Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice. Osteoarthr Cartil 20:562–571CrossRefPubMedCentralPubMed
17.
Honsawek S, Chayanupatkul M, Tanavalee A, Sakdinakiattikoon M, Deepaisarnsakul B, Yuktanandana P, Ngarmukos S (2009) Relationship of plasma and synovial fluid BMP-7 with disease severity in knee osteoarthritis patients: a pilot study. Int Orthop 33:1171–1175CrossRefPubMedCentralPubMed
18.
Honsawek S, Tanavalee A, Yuktanandana P (2009) Elevated circulating and synovial fluid endoglin are associated with primary knee osteoarthritis severity. Arch Med Res 40:590–594CrossRefPubMed
19.
Hunter DJ, Pike MC, Jonas BL, Kissin E, Krop J, McAlindon T (2010) Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis. BMC Musculoskelet Disord 11:232CrossRefPubMedCentralPubMed
20.
21.
Kerr PS, Prothero DL, Atkins RM (1996) Assessing outcome following calcaneal fracture: a rational scoring system. Injury 27:35–38CrossRefPubMed
22.
Kornaat PR, Ceulemans RYT, Kroon HM, Riyazi N, Kloppenburg M, Carter WO, Woodworth TG, Bloem JL (2005) MRI assessment of knee osteoarthritis: knee osteoarthritis scoring system (KOSS)–inter-observer and intra-observer reproducibility of a compartment-based scoring system. Skeletal Radiol 34:95–102CrossRefPubMed
23.
Korompilias AV, Karantanas AH, Lykissas MG, Beris AE (2009) Bone marrow edema syndrome. Skeletal Radiol 38:425–436CrossRefPubMed
24.
Kurose R, Ichinohe S, Tajima G, Horiuchi S, Kurose A, Sawai T, Shimamura T (2010) Characterization of human synovial fluid cells of 26 patients with osteoarthritis knee for cartilage repair therapy. Int J Rheum Dis 13:68–74CrossRefPubMed
25.
Lohmander LS, Dahlberg L, Ryd L, Heinegård D (1989) Increased levels of proteoglycan fragments in knee joint fluid after injury. Arthritis Rheum 32:1434–1442CrossRefPubMed
26.
Madeley NJ, Wing KJ, Topliss C, Penner MJ, Glazebrook MA, Younger AS (2012) Responsiveness and validity of the SF-36, ankle osteoarthritis scale, AOFAS ankle hind foot score, and foot function index in end stage ankle arthritis. Foot Ankle Int 33:57–63CrossRefPubMed
27.
Madry H, Orth P, Kaul G, Zurakowski D, Menger MD, Kohn D, Cucchiarini M (2010) Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivo. Arch Orthop Trauma Surg 130:1311–1322CrossRefPubMed
28.
McCauley TR, Kornaat PR, Jee WH (2001) Central osteophyte in the knee: prevalence and association with cartilage defects on MR imaging. AJR Am J Roentgenol 176:359–364CrossRefPubMed
29.
Moon J-S, Shim J-C, Suh J-S, Lee W-C (2010) Radiographic predictability of cartilage damage in medial ankle osteoarthritis. Clin Orthop Relat Res 468:2188–2197CrossRefPubMedCentralPubMed
30.
Naal FD, Impellizzeri FM, Huber M, Rippstein PF (2008) Cross-cultural adaptation and validation of the foot function index for use in German-speaking patients with foot complaints. Foot Ankle Int 29:1222–1228CrossRefPubMed
31.
Orita S, Koshi T, Mitsuka T, Miyagi M, Inoue G, Arai G, Ishikawa T, Hanaoka E, Yamashita K, Yamashita M, Eguchi Y, Toyone T, Takahashi K, Ohtori S (2011) Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee. BMC Musculoskelet Disord 12:144CrossRefPubMedCentralPubMed
32.
Robinson P, White LM, Salonen DC, Daniels TR, Ogilvie-Harris D (2001) Anterolateral ankle impingement: mr arthrographic assessment of the anterolateral recess. Radiology 221:186–190CrossRefPubMed
33.
34.
Salzmann GM, Sah B-R, Schmal H, Niemeyer P, Sudkamp NP (2012) Micro fracture for treatment of knee cartilage defects in children and adolescents. Pediatr Rep 4:e21CrossRefPubMedCentralPubMed
35.
Schmal H, Mehlhorn A, Stoffel F, Köstler W, Südkamp NP, Niemeyer P (2009) In vivo quantification of intraarticular cytokines in knees during natural and surgically induced cartilage repair. Cytotherapy 11:1065–1075CrossRefPubMed
36.
Schmal H, Niemeyer P, Südkamp NP, Gerlach U, Dovi-Akue D, Mehlhorn AT (2011) Pain perception in knees with circumscribed cartilage lesions is associated with intra-articular IGF-1 expression. Am J Sports Med 39:1989–1996CrossRefPubMed
37.
Schmal H, Niemeyer P, Zwingmann J, Stoffel F, Südkamp NP, Mehlhorn AT (2010) Association between expression of the bone morphogenetic proteins 2 and 7 in the repair of circumscribed cartilage lesions with clinical outcome. BMC Musculoskelet Disord 11:170CrossRefPubMedCentralPubMed
38.
Schmal H, Pestka JM, Salzmann G, Strohm PC, Südkamp NP, Niemeyer P (2013) Autologous chondrocyte implantation in children and adolescents. Knee Surg Sports Traumatol Arthrosc 21:671–677CrossRefPubMed
39.
Schmal H, Zwingmann J, Fehrenbach M, Finkenzeller G, Stark GB, Südkamp NP, Hartl D, Mehlhorn AT (2007) bFGF influences human articular chondrocyte differentiation. Cytotherapy 9:184–193CrossRefPubMed
40.
Schuh A, Hausel M (2000) Difficulties in evaluating follow-up outcome in calcaneus fracture managed with plate osteosynthesis. Is there a reliable score? Unfallchirurg 103:295–300CrossRefPubMed
41.
42.
Spector TD, Hart DJ, Doyle DV (1994) Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population: the effect of obesity. Ann Rheum Dis 53:565–568CrossRefPubMedCentralPubMed
43.
Ba-Ssalamah A, Schibany N, Puig S, Herneth AM, Noebauer-Huhmann IM, Trattnig S (2002) Imaging articular cartilage defects in the ankle joint with 3D fat-suppressed echo planar imaging: comparison with conventional 3D fat-suppressed gradient echo imaging. J Magn Reson Imaging 16:209–216CrossRefPubMed
44.
Yulish BS, Montanez J, Goodfellow DB, Bryan PJ, Mulopulos GP, Modic MT (1987) Chondromalacia patellae: assessment with MR imaging. Radiology 164:763–766CrossRefPubMed
45.
Zanetti M, De Simoni C, Wetz HH, Zollinger H, Hodler J (1997) Magnetic resonance imaging of injuries to the ankle joint: can it predict clinical outcome? Skeletal Radiol 26:82–88CrossRefPubMed
Metadata
Title
Synovial cytokine expression in ankle osteoarthritis depends on age and stage
Authors
Hagen Schmal
Ralf Henkelmann
Alexander T. Mehlhorn
Kilian Reising
Gerrit Bode
Norbert P. Südkamp
Philipp Niemeyer
Publication date
01-05-2015
Publisher
Springer Berlin Heidelberg
Published in
Knee Surgery, Sports Traumatology, Arthroscopy / Issue 5/2015
Print ISSN: 0942-2056
Electronic ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-013-2719-1

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