Skip to main content
Top
Published in: Intensive Care Medicine 2/2014

01-02-2014 | Review

Palliative care in the ICU: relief of pain, dyspnea, and thirst—A report from the IPAL-ICU Advisory Board

Authors: Kathleen Puntillo, Judith Eve Nelson, David Weissman, Randall Curtis, Stefanie Weiss, Jennifer Frontera, Michelle Gabriel, Ross Hays, Dana Lustbader, Anne Mosenthal, Colleen Mulkerin, Daniel Ray, Rick Bassett, Renee Boss, Karen Brasel, Margaret Campbell

Published in: Intensive Care Medicine | Issue 2/2014

Login to get access

Abstract

Purpose

Pain, dyspnea, and thirst are three of the most prevalent, intense, and distressing symptoms of intensive care unit (ICU) patients. In this report, the interdisciplinary Advisory Board of the Improving Palliative Care in the ICU (IPAL-ICU) Project brings together expertise in both critical care and palliative care along with current information to address challenges in assessment and management.

Methods

We conducted a comprehensive review of literature focusing on intensive care and palliative care research related to palliation of pain, dyspnea, and thirst.

Results

Evidence-based methods to assess pain are the enlarged 0–10 Numeric Rating Scale (NRS) for ICU patients able to self-report and the Critical Care Pain Observation Tool or Behavior Pain Scale for patients who cannot report symptoms verbally or non-verbally. The Respiratory Distress Observation Scale is the only known behavioral scale for assessment of dyspnea, and thirst is evaluated by patient self-report using an 0–10 NRS. Opioids remain the mainstay for pain management, and all available intravenous opioids, when titrated to similar pain intensity end points, are equally effective. Dyspnea is treated (with or without invasive or noninvasive mechanical ventilation) by optimizing the underlying etiological condition, patient positioning and, sometimes, supplemental oxygen. Several oral interventions are recommended to alleviate thirst. Systematized improvement efforts addressing symptom management and assessment can be implemented in ICUs.

Conclusions

Relief of symptom distress is a key component of critical care for all ICU patients, regardless of condition or prognosis. Evidence-based approaches for assessment and treatment together with well-designed work systems can help ensure comfort and related favorable outcomes for the critically ill.
Literature
1.
go back to reference Nelson JE, Puntillo KA, Pronovost PJ, Walker AS, McAdam JL, Ilaoa D, Penrod J (2010) In their own words: patients and families define high-quality palliative care in the intensive care unit. Crit Care Med 38:808–818PubMedCentralPubMedCrossRef Nelson JE, Puntillo KA, Pronovost PJ, Walker AS, McAdam JL, Ilaoa D, Penrod J (2010) In their own words: patients and families define high-quality palliative care in the intensive care unit. Crit Care Med 38:808–818PubMedCentralPubMedCrossRef
3.
go back to reference Swinamer DL, Phang PT, Jones RL, Grace M, King EG (1988) Effect of routine administration of analgesia on energy expenditure in critically ill patients. Chest 93:4–10PubMedCrossRef Swinamer DL, Phang PT, Jones RL, Grace M, King EG (1988) Effect of routine administration of analgesia on energy expenditure in critically ill patients. Chest 93:4–10PubMedCrossRef
4.
go back to reference Karaman S, Kocabas S, Uyar M, Zincircioglu C, Firat V (2006) Intrathecal morphine: effects on perioperative hemodynamics, postoperative analgesia, and stress response for total abdominal hysterectomy. Adv Ther 23:295–306PubMedCrossRef Karaman S, Kocabas S, Uyar M, Zincircioglu C, Firat V (2006) Intrathecal morphine: effects on perioperative hemodynamics, postoperative analgesia, and stress response for total abdominal hysterectomy. Adv Ther 23:295–306PubMedCrossRef
5.
go back to reference Lewis KS, Whipple JK, Michael KA, Quebbeman EJ (1994) Effect of analgesic treatment on the physiological consequences of acute pain. Am J Hosp Pharm 51:1539–1554PubMed Lewis KS, Whipple JK, Michael KA, Quebbeman EJ (1994) Effect of analgesic treatment on the physiological consequences of acute pain. Am J Hosp Pharm 51:1539–1554PubMed
6.
go back to reference Chanques G, Jaber S, Barbotte E, Violet S, Sebbane M, Perrigault PF, Mann C, Lefrant JY, Eledjam JJ (2006) Impact of systematic evaluation of pain and agitation in an intensive care unit. Crit Care Med 34:1691–1699PubMedCrossRef Chanques G, Jaber S, Barbotte E, Violet S, Sebbane M, Perrigault PF, Mann C, Lefrant JY, Eledjam JJ (2006) Impact of systematic evaluation of pain and agitation in an intensive care unit. Crit Care Med 34:1691–1699PubMedCrossRef
7.
go back to reference Barr J, Fraser GL, Puntillo K, Ely EW, Gelinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 41:263–306PubMedCrossRef Barr J, Fraser GL, Puntillo K, Ely EW, Gelinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 41:263–306PubMedCrossRef
8.
go back to reference Mahler DA, Selecky PA, Harrod CG, Benditt JO, Carrieri-Kohlman V, Curtis JR, Manning HL, Mularski RA, Varkey B, Campbell M, Carter ER, Chiong JR, Ely EW, Hansen-Flaschen J, O’Donnell DE, Waller A (2010) American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest 137:674–691PubMedCrossRef Mahler DA, Selecky PA, Harrod CG, Benditt JO, Carrieri-Kohlman V, Curtis JR, Manning HL, Mularski RA, Varkey B, Campbell M, Carter ER, Chiong JR, Ely EW, Hansen-Flaschen J, O’Donnell DE, Waller A (2010) American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest 137:674–691PubMedCrossRef
9.
go back to reference Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, Calverley PM, Gift AG, Harver A, Lareau SC, Mahler DA, Meek PM, O’Donnell DE (2012) An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med 185:435–452PubMedCrossRef Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, Calverley PM, Gift AG, Harver A, Lareau SC, Mahler DA, Meek PM, O’Donnell DE (2012) An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med 185:435–452PubMedCrossRef
10.
go back to reference Puntillo KA (1990) Pain experiences of intensive care unit patients. Heart Lung 19:526–533PubMed Puntillo KA (1990) Pain experiences of intensive care unit patients. Heart Lung 19:526–533PubMed
11.
go back to reference Gelinas C (2007) Management of pain in cardiac surgery ICU patients: have we improved over time? Intensive Crit Care Nurs 23:298–303PubMedCrossRef Gelinas C (2007) Management of pain in cardiac surgery ICU patients: have we improved over time? Intensive Crit Care Nurs 23:298–303PubMedCrossRef
12.
go back to reference Nelson JE, Meier DE, Oei EJ, Nierman DM, Senzel RS, Manfredi PL, Davis SM, Morrison RS (2001) Self-reported symptom experience of critically ill cancer patients receiving intensive care. Crit Care Med 29:277–282PubMedCrossRef Nelson JE, Meier DE, Oei EJ, Nierman DM, Senzel RS, Manfredi PL, Davis SM, Morrison RS (2001) Self-reported symptom experience of critically ill cancer patients receiving intensive care. Crit Care Med 29:277–282PubMedCrossRef
13.
go back to reference Puntillo KA, Arai S, Cohen NH, Gropper MA, Neuhaus J, Paul SM, Miaskowski C (2010) Symptoms experienced by intensive care unit patients at high risk of dying. Crit Care Med 38:2155–2160PubMedCentralPubMedCrossRef Puntillo KA, Arai S, Cohen NH, Gropper MA, Neuhaus J, Paul SM, Miaskowski C (2010) Symptoms experienced by intensive care unit patients at high risk of dying. Crit Care Med 38:2155–2160PubMedCentralPubMedCrossRef
14.
go back to reference Schmidt M, Demoule A, Polito A, Porchet R, Aboab J, Siami S, Morelot-Panzini C, Similowski T, Sharshar T (2011) Dyspnea in mechanically ventilated critically ill patients. Crit Care Med 39:2059–2065PubMedCrossRef Schmidt M, Demoule A, Polito A, Porchet R, Aboab J, Siami S, Morelot-Panzini C, Similowski T, Sharshar T (2011) Dyspnea in mechanically ventilated critically ill patients. Crit Care Med 39:2059–2065PubMedCrossRef
15.
go back to reference Puntillo KA, White C, Morris AB, Perdue ST, Stanik-Hutt J, Thompson CL, Wild LR (2001) Patients’ perceptions and responses to procedural pain: results from Thunder Project II. Am J Crit Care 10:238–251PubMed Puntillo KA, White C, Morris AB, Perdue ST, Stanik-Hutt J, Thompson CL, Wild LR (2001) Patients’ perceptions and responses to procedural pain: results from Thunder Project II. Am J Crit Care 10:238–251PubMed
16.
go back to reference Puntillo KA (1994) Dimensions of procedural pain and its analgesic management in critically ill surgical patients. Am J Crit Care 3:116–122PubMed Puntillo KA (1994) Dimensions of procedural pain and its analgesic management in critically ill surgical patients. Am J Crit Care 3:116–122PubMed
17.
go back to reference Campbell ML (2012) Dyspnea prevalence, trajectories, and measurement in critical care and at life’s end. Curr Opin Support Palliat Care 6:168–171PubMedCrossRef Campbell ML (2012) Dyspnea prevalence, trajectories, and measurement in critical care and at life’s end. Curr Opin Support Palliat Care 6:168–171PubMedCrossRef
18.
go back to reference Mularski RA, Campbell ML, Asch SM, Reeve BB, Basch E, Maxwell TL, Hoverman JR, Cuny J, Clauser SB, Snyder C, Seow H, Wu AW, Dy S (2010) A review of quality of care evaluation for the palliation of dyspnea. Am J Respir Crit Care Med 181:534–538PubMedCrossRef Mularski RA, Campbell ML, Asch SM, Reeve BB, Basch E, Maxwell TL, Hoverman JR, Cuny J, Clauser SB, Snyder C, Seow H, Wu AW, Dy S (2010) A review of quality of care evaluation for the palliation of dyspnea. Am J Respir Crit Care Med 181:534–538PubMedCrossRef
19.
go back to reference Puntillo K, Weiss SJ (1994) Pain: its mediators and associated morbidity in critically ill cardiovascular surgical patients. Nurs Res 43:31–36PubMedCrossRef Puntillo K, Weiss SJ (1994) Pain: its mediators and associated morbidity in critically ill cardiovascular surgical patients. Nurs Res 43:31–36PubMedCrossRef
20.
go back to reference Puntillo K, Ley SJ (2004) Appropriately timed analgesics control pain due to chest tube removal. Am J Crit Care 13:292–301PubMed Puntillo K, Ley SJ (2004) Appropriately timed analgesics control pain due to chest tube removal. Am J Crit Care 13:292–301PubMed
21.
go back to reference Arai S, Cooper B, Nelson JE, Stotts N, Puntillo K (2012) A thirst intervention bundle decreases the distress of ICU patients’ thirst. Crit Care Med 40(12) (abstract no. 124) Arai S, Cooper B, Nelson JE, Stotts N, Puntillo K (2012) A thirst intervention bundle decreases the distress of ICU patients’ thirst. Crit Care Med 40(12) (abstract no. 124)
22.
go back to reference Chanques G, Viel E, Constantin JM, Jung B, de Lattre S, Carr J, Cisse M, Lefrant JY, Jaber S (2010) The measurement of pain in intensive care unit: comparison of 5 self-report intensity scales. Pain 151:711–721PubMedCrossRef Chanques G, Viel E, Constantin JM, Jung B, de Lattre S, Carr J, Cisse M, Lefrant JY, Jaber S (2010) The measurement of pain in intensive care unit: comparison of 5 self-report intensity scales. Pain 151:711–721PubMedCrossRef
23.
go back to reference Gift A (1989) Validation of a vertical visual analogue scale as a measure of clinical dyspnea. Rehabil Nurs 14:323–325PubMedCrossRef Gift A (1989) Validation of a vertical visual analogue scale as a measure of clinical dyspnea. Rehabil Nurs 14:323–325PubMedCrossRef
24.
go back to reference Chang VT, Hwang SS, Kasimis B, Thaler HT (2004) Shorter symptom assessment instruments: the Condensed Memorial Symptom Assessment Scale (CMSAS). Cancer Invest 22:526–536PubMedCrossRef Chang VT, Hwang SS, Kasimis B, Thaler HT (2004) Shorter symptom assessment instruments: the Condensed Memorial Symptom Assessment Scale (CMSAS). Cancer Invest 22:526–536PubMedCrossRef
25.
go back to reference Bruera E, Kuehn N, Miller MJ, Selmser P, Macmillan K (1991) The Edmonton Symptom Assessment System (ESAS): a simple method for the assessment of palliative care patients. J Palliat Care 7:6–9PubMed Bruera E, Kuehn N, Miller MJ, Selmser P, Macmillan K (1991) The Edmonton Symptom Assessment System (ESAS): a simple method for the assessment of palliative care patients. J Palliat Care 7:6–9PubMed
26.
go back to reference Radtke JV, Baumann BM, Garrett KL, Happ MB (2011) Listening to the voiceless patient: case reports in assisted communication in the intensive care unit. J Palliat Med 14:791–795PubMedCrossRef Radtke JV, Baumann BM, Garrett KL, Happ MB (2011) Listening to the voiceless patient: case reports in assisted communication in the intensive care unit. J Palliat Med 14:791–795PubMedCrossRef
27.
go back to reference Payen JF, Bru O, Bosson JL, Lagrasta A, Novel E, Deschaux I, Lavagne P, Jacquot C (2001) Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med 29:2258–2263PubMedCrossRef Payen JF, Bru O, Bosson JL, Lagrasta A, Novel E, Deschaux I, Lavagne P, Jacquot C (2001) Assessing pain in critically ill sedated patients by using a behavioral pain scale. Crit Care Med 29:2258–2263PubMedCrossRef
28.
go back to reference Gelinas C, Fillion L, Puntillo KA, Viens C, Fortier M (2006) Validation of the critical-care pain observation tool in adult patients. Am J Crit Care 15:420–427PubMed Gelinas C, Fillion L, Puntillo KA, Viens C, Fortier M (2006) Validation of the critical-care pain observation tool in adult patients. Am J Crit Care 15:420–427PubMed
29.
go back to reference Puntillo KA, Morris A, Thompson CL, Stanik-Hutt J, White CA, Wild LR (2004) Pain behaviors observed during six common procedures: results from Thunder Project II. Crit Care Med 32:421–427PubMedCrossRef Puntillo KA, Morris A, Thompson CL, Stanik-Hutt J, White CA, Wild LR (2004) Pain behaviors observed during six common procedures: results from Thunder Project II. Crit Care Med 32:421–427PubMedCrossRef
30.
go back to reference Campbell ML (2007) Fear and pulmonary stress behaviors to an asphyxial threat across cognitive states. Res Nurs Health 30:572–583PubMedCrossRef Campbell ML (2007) Fear and pulmonary stress behaviors to an asphyxial threat across cognitive states. Res Nurs Health 30:572–583PubMedCrossRef
31.
go back to reference Campbell ML (2008) Psychometric testing of a respiratory distress observation scale. J Palliat Med 11:44–50PubMedCrossRef Campbell ML (2008) Psychometric testing of a respiratory distress observation scale. J Palliat Med 11:44–50PubMedCrossRef
32.
go back to reference Campbell ML, Templin T, Walch J (2010) A respiratory distress observation scale for patients unable to self-report dyspnea. J Palliat Med 13:285–290PubMedCrossRef Campbell ML, Templin T, Walch J (2010) A respiratory distress observation scale for patients unable to self-report dyspnea. J Palliat Med 13:285–290PubMedCrossRef
33.
go back to reference Nekolaichuk CL, Bruera E, Spachynski K, MacEachern T, Hanson J, Maguire TO (1999) A comparison of patient and proxy symptom assessments in advanced cancer patients. Palliat Med 13:311–323PubMedCrossRef Nekolaichuk CL, Bruera E, Spachynski K, MacEachern T, Hanson J, Maguire TO (1999) A comparison of patient and proxy symptom assessments in advanced cancer patients. Palliat Med 13:311–323PubMedCrossRef
34.
go back to reference Neighbor ML, Puntillo K, O’Neill B (1999) Nurse underestimation of patient pain intensity (abstract). Acad Emerg Med 6:514 Neighbor ML, Puntillo K, O’Neill B (1999) Nurse underestimation of patient pain intensity (abstract). Acad Emerg Med 6:514
35.
go back to reference Miaskowski C, Zimmer EF, Barrett KM, Dibble SL, Wallhagen M (1997) Differences in patients’ and family caregivers’ perceptions of the pain experience influence patient and caregiver outcomes. Pain 72:217–226PubMedCrossRef Miaskowski C, Zimmer EF, Barrett KM, Dibble SL, Wallhagen M (1997) Differences in patients’ and family caregivers’ perceptions of the pain experience influence patient and caregiver outcomes. Pain 72:217–226PubMedCrossRef
36.
go back to reference Ferrell BR, Grant M, Borneman T, Juarez G, ter Veer A (1999) Family caregiving in cancer pain management. J Palliat Med 2:185–195PubMedCrossRef Ferrell BR, Grant M, Borneman T, Juarez G, ter Veer A (1999) Family caregiving in cancer pain management. J Palliat Med 2:185–195PubMedCrossRef
37.
go back to reference Puntillo KA, Neuhaus J, Arai S, Paul SM, Gropper MA, Cohen NH, Miaskowski C (2012) Challenge of assessing symptoms in seriously ill intensive care unit patients: can proxy reporters help? Crit Care Med 40:2760–2767PubMedCentralPubMedCrossRef Puntillo KA, Neuhaus J, Arai S, Paul SM, Gropper MA, Cohen NH, Miaskowski C (2012) Challenge of assessing symptoms in seriously ill intensive care unit patients: can proxy reporters help? Crit Care Med 40:2760–2767PubMedCentralPubMedCrossRef
38.
go back to reference Herr K, Coyne PJ, Key T, Manworren R, McCaffery M, Merkel S, Pelosi-Kelly J, Wild L (2006) Pain assessment in the nonverbal patient: position statement with clinical practice recommendations. Pain Manag Nurs 7:44–52PubMedCrossRef Herr K, Coyne PJ, Key T, Manworren R, McCaffery M, Merkel S, Pelosi-Kelly J, Wild L (2006) Pain assessment in the nonverbal patient: position statement with clinical practice recommendations. Pain Manag Nurs 7:44–52PubMedCrossRef
39.
go back to reference Puntillo K, Pasero C, Li D, Mularski RA, Grap MJ, Erstad BL, Varkey B, Gilbert HC, Medina J, Sessler CN (2009) Evaluation of pain in ICU patients. Chest 135:1069–1074PubMedCrossRef Puntillo K, Pasero C, Li D, Mularski RA, Grap MJ, Erstad BL, Varkey B, Gilbert HC, Medina J, Sessler CN (2009) Evaluation of pain in ICU patients. Chest 135:1069–1074PubMedCrossRef
40.
go back to reference Payen JF, Chanques G, Mantz J, Hercule C, Auriant I, Leguillou JL, Binhas M, Genty C, Rolland C, Bosson JL (2007) Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology 106:687–695PubMedCrossRef Payen JF, Chanques G, Mantz J, Hercule C, Auriant I, Leguillou JL, Binhas M, Genty C, Rolland C, Bosson JL (2007) Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology 106:687–695PubMedCrossRef
41.
go back to reference Memis D, Inal MT, Kavalci G, Sezer A, Sut N (2010) Intravenous paracetamol reduced the use of opioids, extubation time, and opioid-related adverse effects after major surgery in intensive care unit. J Crit Care 25:458–462PubMedCrossRef Memis D, Inal MT, Kavalci G, Sezer A, Sut N (2010) Intravenous paracetamol reduced the use of opioids, extubation time, and opioid-related adverse effects after major surgery in intensive care unit. J Crit Care 25:458–462PubMedCrossRef
42.
go back to reference Schmittner MD, Vajkoczy SL, Horn P, Bertsch T, Quintel M, Vajkoczy P, Muench E (2007) Effects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and need of vasopressors in patients with intracranial pathologies: a pilot study. J Neurosurg Anesthesiol 19:257–262PubMedCrossRef Schmittner MD, Vajkoczy SL, Horn P, Bertsch T, Quintel M, Vajkoczy P, Muench E (2007) Effects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and need of vasopressors in patients with intracranial pathologies: a pilot study. J Neurosurg Anesthesiol 19:257–262PubMedCrossRef
43.
go back to reference Payen JF, Genty C, Mimoz O, Mantz J, Bosson JL, Chanques G (2013) Prescribing nonopioids in mechanically ventilated critically ill patients. J Crit Care 28:534.e7–534.e12CrossRef Payen JF, Genty C, Mimoz O, Mantz J, Bosson JL, Chanques G (2013) Prescribing nonopioids in mechanically ventilated critically ill patients. J Crit Care 28:534.e7–534.e12CrossRef
44.
go back to reference Chanques G, Sebbane M, Constantin JM, Ramillon N, Jung B, Cisse M, Lefrant JY, Jaber S (2011) Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients. Br J Anaesth 106:336–343PubMedCrossRef Chanques G, Sebbane M, Constantin JM, Ramillon N, Jung B, Cisse M, Lefrant JY, Jaber S (2011) Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients. Br J Anaesth 106:336–343PubMedCrossRef
45.
go back to reference Maddali MM, Kurian E, Fahr J (2006) Extubation time, hemodynamic stability, and postoperative pain control in patients undergoing coronary artery bypass surgery: an evaluation of fentanyl, remifentanil, and nonsteroidal antiinflammatory drugs with propofol for perioperative and postoperative management. J Clin Anesth 18:605–610PubMedCrossRef Maddali MM, Kurian E, Fahr J (2006) Extubation time, hemodynamic stability, and postoperative pain control in patients undergoing coronary artery bypass surgery: an evaluation of fentanyl, remifentanil, and nonsteroidal antiinflammatory drugs with propofol for perioperative and postoperative management. J Clin Anesth 18:605–610PubMedCrossRef
46.
go back to reference Erstad BL, Puntillo K, Gilbert HC, Grap MJ, Li D, Medina J, Mularski RA, Pasero C, Varkey B, Sessler CN (2009) Pain management principles in the critically ill. Chest 135:1075–1086PubMedCrossRef Erstad BL, Puntillo K, Gilbert HC, Grap MJ, Li D, Medina J, Mularski RA, Pasero C, Varkey B, Sessler CN (2009) Pain management principles in the critically ill. Chest 135:1075–1086PubMedCrossRef
47.
go back to reference Pandey CK, Bose N, Garg G, Singh N, Baronia A, Agarwal A, Singh PK, Singh U (2002) Gabapentin for the treatment of pain in Guillain–Barre syndrome: a double-blinded, placebo-controlled, crossover study. Anesth Analg 95:1719–1723PubMedCrossRef Pandey CK, Bose N, Garg G, Singh N, Baronia A, Agarwal A, Singh PK, Singh U (2002) Gabapentin for the treatment of pain in Guillain–Barre syndrome: a double-blinded, placebo-controlled, crossover study. Anesth Analg 95:1719–1723PubMedCrossRef
48.
go back to reference Pandey CK, Raza M, Tripathi M, Navkar DV, Kumar A, Singh UK (2005) The comparative evaluation of gabapentin and carbamazepine for pain management in Guillain–Barre syndrome patients in the intensive care unit. Anesth Analg 101:220–225PubMedCrossRef Pandey CK, Raza M, Tripathi M, Navkar DV, Kumar A, Singh UK (2005) The comparative evaluation of gabapentin and carbamazepine for pain management in Guillain–Barre syndrome patients in the intensive care unit. Anesth Analg 101:220–225PubMedCrossRef
49.
go back to reference Pettersson PH, Jakobsson J, Owall A (2005) Intravenous acetaminophen reduced the use of opioids compared with oral administration after coronary artery bypass grafting. J Cardiothorac Vasc Anesth 19:306–309PubMedCrossRef Pettersson PH, Jakobsson J, Owall A (2005) Intravenous acetaminophen reduced the use of opioids compared with oral administration after coronary artery bypass grafting. J Cardiothorac Vasc Anesth 19:306–309PubMedCrossRef
50.
go back to reference De Pinto M, Jelacic J, Edwards WT (2008) Very-low-dose ketamine for the management of pain and sedation in the ICU. J Opioid Manag 4:54–56PubMed De Pinto M, Jelacic J, Edwards WT (2008) Very-low-dose ketamine for the management of pain and sedation in the ICU. J Opioid Manag 4:54–56PubMed
52.
go back to reference Pasero C, Puntillo K, Li D, Mularski RA, Grap MJ, Erstad BL, Varkey B, Gilbert HC, Medina J, Sessler CN (2009) Structured approaches to pain management in the ICU. Chest 135:1665–1672PubMedCrossRef Pasero C, Puntillo K, Li D, Mularski RA, Grap MJ, Erstad BL, Varkey B, Gilbert HC, Medina J, Sessler CN (2009) Structured approaches to pain management in the ICU. Chest 135:1665–1672PubMedCrossRef
53.
go back to reference Banzett RB, Adams L, O’Donnell CR, Gilman SA, Lansing RW, Schwartzstein RM (2011) Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response. Am J Respir Crit Care Med 184:920–927PubMedCrossRef Banzett RB, Adams L, O’Donnell CR, Gilman SA, Lansing RW, Schwartzstein RM (2011) Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response. Am J Respir Crit Care Med 184:920–927PubMedCrossRef
54.
go back to reference Jennings AL, Davies AN, Higgins JP, Gibbs JS, Broadley KE (2002) A systematic review of the use of opioids in the management of dyspnea. Thorax 57:939–944PubMedCrossRef Jennings AL, Davies AN, Higgins JP, Gibbs JS, Broadley KE (2002) A systematic review of the use of opioids in the management of dyspnea. Thorax 57:939–944PubMedCrossRef
55.
go back to reference Currow DC, McDonald C, Oaten S, Kenny B, Allcroft P, Frith P, Briffa M, Johnson MJ, Abernethy AP (2011) Once-daily opioids for chronic dyspnea: a dose increment and pharmacovigilance study. J Pain Symptom Manag 42:388–399CrossRef Currow DC, McDonald C, Oaten S, Kenny B, Allcroft P, Frith P, Briffa M, Johnson MJ, Abernethy AP (2011) Once-daily opioids for chronic dyspnea: a dose increment and pharmacovigilance study. J Pain Symptom Manag 42:388–399CrossRef
56.
go back to reference Cepeda MS, Carr DB, Lau J, Alvarez H (2006) Music for pain relief. Cochrane Database Syst Rev 2:CD004843PubMed Cepeda MS, Carr DB, Lau J, Alvarez H (2006) Music for pain relief. Cochrane Database Syst Rev 2:CD004843PubMed
57.
go back to reference (1992) Availability of clinical practice guidelines on acute pain management: operative or medical procedures and trauma and urinary incontinence in adults—AHCPR. Fed Regist 57:12829–12831 (1992) Availability of clinical practice guidelines on acute pain management: operative or medical procedures and trauma and urinary incontinence in adults—AHCPR. Fed Regist 57:12829–12831
58.
go back to reference Curtis JR, Cook DJ, Sinuff T, White DB, Hill N, Keenan SP, Benditt JO, Kacmarek R, Kirchhoff KT, Levy MM (2007) Noninvasive positive pressure ventilation in critical and palliative care settings: understanding the goals of therapy. Crit Care Med 35:932–939PubMedCrossRef Curtis JR, Cook DJ, Sinuff T, White DB, Hill N, Keenan SP, Benditt JO, Kacmarek R, Kirchhoff KT, Levy MM (2007) Noninvasive positive pressure ventilation in critical and palliative care settings: understanding the goals of therapy. Crit Care Med 35:932–939PubMedCrossRef
59.
go back to reference Nava S, Ferrer M, Esquinas A, Scala R, Groff P, Cosentini R, Guido D, Lin CH, Cuomo AM, Grassi M (2013) Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial. Lancet Oncol 14:219–227PubMedCrossRef Nava S, Ferrer M, Esquinas A, Scala R, Groff P, Cosentini R, Guido D, Lin CH, Cuomo AM, Grassi M (2013) Palliative use of non-invasive ventilation in end-of-life patients with solid tumours: a randomised feasibility trial. Lancet Oncol 14:219–227PubMedCrossRef
60.
go back to reference Azoulay E, Kouatchet A, Jaber S et al (2013) Noninvasive mechanical ventilation in patients having declined tracheal intubation. Intensive Care Med 39:292–301PubMedCrossRef Azoulay E, Kouatchet A, Jaber S et al (2013) Noninvasive mechanical ventilation in patients having declined tracheal intubation. Intensive Care Med 39:292–301PubMedCrossRef
61.
go back to reference Azoulay E, Kouatchet A, Jaber S, Mexiani F, Papazian L, Brochard L, Demoule A (2013) Non-invasive ventilation for end-of-life oncology patients. Lancet Oncol 14:200–201CrossRef Azoulay E, Kouatchet A, Jaber S, Mexiani F, Papazian L, Brochard L, Demoule A (2013) Non-invasive ventilation for end-of-life oncology patients. Lancet Oncol 14:200–201CrossRef
62.
go back to reference Barach AL (1974) Chronic obstructive lung disease: postural relief of dyspnea. Arch Phys Med Rehabil 55:494–504PubMed Barach AL (1974) Chronic obstructive lung disease: postural relief of dyspnea. Arch Phys Med Rehabil 55:494–504PubMed
63.
go back to reference Sharp JT, Drutz WS, Moisan T, Foster J, Machnach W (1980) Postural relief of dyspnea in severe chronic obstructive lung disease. Am Rev Respir Dis 122:201–211PubMed Sharp JT, Drutz WS, Moisan T, Foster J, Machnach W (1980) Postural relief of dyspnea in severe chronic obstructive lung disease. Am Rev Respir Dis 122:201–211PubMed
64.
go back to reference Qaseem A, Snow V, Shekelle P, Casey DE, Cross JT, Owens DK, Dallas P, Dolan NC, Forciea MA, Halasyamani L, Hopkins RH (2008) Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians. Ann Intern Med 148:141–146PubMedCrossRef Qaseem A, Snow V, Shekelle P, Casey DE, Cross JT, Owens DK, Dallas P, Dolan NC, Forciea MA, Halasyamani L, Hopkins RH (2008) Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians. Ann Intern Med 148:141–146PubMedCrossRef
65.
go back to reference Guyatt GH, McKim DA, Austin P, Bryan R, Norgren J, Weaver B, Goldstein RS (2000) Appropriateness of domiciliary oxygen delivery. Chest 118:1303–1308PubMedCrossRef Guyatt GH, McKim DA, Austin P, Bryan R, Norgren J, Weaver B, Goldstein RS (2000) Appropriateness of domiciliary oxygen delivery. Chest 118:1303–1308PubMedCrossRef
66.
go back to reference Lorenz KA, Lynn J, Dy SM, Shugarman LR, Wilkinson A, Mularski RA, Morton SC, Hughes RG, Hilton LK, Maglione M, Rhodes SL, Rolon C, Sun VC, Shekelle PG (2008) Evidence for improving palliative care at the end of life: a systematic review. Ann Intern Med 148:147–159PubMedCrossRef Lorenz KA, Lynn J, Dy SM, Shugarman LR, Wilkinson A, Mularski RA, Morton SC, Hughes RG, Hilton LK, Maglione M, Rhodes SL, Rolon C, Sun VC, Shekelle PG (2008) Evidence for improving palliative care at the end of life: a systematic review. Ann Intern Med 148:147–159PubMedCrossRef
67.
go back to reference Cranston JM, Crockett A, Currow D (2008) Oxygen therapy for dyspnoea in adults. Cochrane Database Syst Rev 3:CD004769PubMed Cranston JM, Crockett A, Currow D (2008) Oxygen therapy for dyspnoea in adults. Cochrane Database Syst Rev 3:CD004769PubMed
68.
go back to reference Abernethy AP, McDonald CF, Frith PA, Clark K, Herndon JE 2nd, Marcello J, Young IH, Bull J, Wilcock A, Booth S, Wheeler JL, Tulsky JA, Crockett AJ, Currow DC (2010) Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet 376:784–793PubMedCentralPubMedCrossRef Abernethy AP, McDonald CF, Frith PA, Clark K, Herndon JE 2nd, Marcello J, Young IH, Bull J, Wilcock A, Booth S, Wheeler JL, Tulsky JA, Crockett AJ, Currow DC (2010) Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet 376:784–793PubMedCentralPubMedCrossRef
69.
go back to reference Campbell ML, Yarandi H, Dove-Medows E (2013) Oxygen is non-beneficial for most patients who are near death. J Pain Symptom Manag 45:517–523CrossRef Campbell ML, Yarandi H, Dove-Medows E (2013) Oxygen is non-beneficial for most patients who are near death. J Pain Symptom Manag 45:517–523CrossRef
70.
go back to reference Bausewein C, Booth S, Gysels M, Kuhnbach R, Higginson IJ (2010) Effectiveness of a hand-held fan for breathlessness: a randomised phase II trial. BMC Palliat Care 9:22PubMedCentralPubMedCrossRef Bausewein C, Booth S, Gysels M, Kuhnbach R, Higginson IJ (2010) Effectiveness of a hand-held fan for breathlessness: a randomised phase II trial. BMC Palliat Care 9:22PubMedCentralPubMedCrossRef
71.
go back to reference Rocker G, Horton R, Currow D, Goodridge D, Young J, Booth S (2009) Palliation of dyspnoea in advanced COPD: revisiting a role for opioids. Thorax 64:910–915PubMedCrossRef Rocker G, Horton R, Currow D, Goodridge D, Young J, Booth S (2009) Palliation of dyspnoea in advanced COPD: revisiting a role for opioids. Thorax 64:910–915PubMedCrossRef
72.
go back to reference Simon ST, Higginson IJ, Booth S, Harding R, Bausewein C (2010) Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev 1:CD007354PubMed Simon ST, Higginson IJ, Booth S, Harding R, Bausewein C (2010) Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev 1:CD007354PubMed
73.
go back to reference Navigante AH, Cerchietti LC, Castro MA, Lutteral MA, Cabalar ME (2006) Midazolam as adjunct therapy to morphine in the alleviation of severe dyspnea perception in patients with advanced cancer. J Pain Symptom Manag 31:38–47CrossRef Navigante AH, Cerchietti LC, Castro MA, Lutteral MA, Cabalar ME (2006) Midazolam as adjunct therapy to morphine in the alleviation of severe dyspnea perception in patients with advanced cancer. J Pain Symptom Manag 31:38–47CrossRef
74.
go back to reference Sironi O, Sbanotto A, Banfi MG, Beltrami C (2007) Midazolam as adjunct therapy to morphine to relieve dyspnea? J Pain Symptom Manag 33:233–234CrossRef Sironi O, Sbanotto A, Banfi MG, Beltrami C (2007) Midazolam as adjunct therapy to morphine to relieve dyspnea? J Pain Symptom Manag 33:233–234CrossRef
75.
go back to reference Ship JA, McCutcheon JA, Spivakovsky S, Kerr AR (2007) Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J Oral Rehabil 34:724–732PubMedCrossRef Ship JA, McCutcheon JA, Spivakovsky S, Kerr AR (2007) Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J Oral Rehabil 34:724–732PubMedCrossRef
76.
go back to reference Cho EA, Kim KH, Park JY (2010) Effects of frozen gauze with normal saline and ice on thirst and oral condition of laparoscopic cholecystectomy patients: pilot study. J Korean Acad Nurs 40:714–723PubMedCrossRef Cho EA, Kim KH, Park JY (2010) Effects of frozen gauze with normal saline and ice on thirst and oral condition of laparoscopic cholecystectomy patients: pilot study. J Korean Acad Nurs 40:714–723PubMedCrossRef
77.
go back to reference Wiley SB (1969) Why glycerol and lemon juice? Am J Nurs 69:342–344PubMed Wiley SB (1969) Why glycerol and lemon juice? Am J Nurs 69:342–344PubMed
78.
go back to reference Van Drimmelen J, Rollins HF (1969) Evaluation of a commonly used oral hygiene agent. Nurs Res 18:327–332PubMed Van Drimmelen J, Rollins HF (1969) Evaluation of a commonly used oral hygiene agent. Nurs Res 18:327–332PubMed
79.
go back to reference Meurman JH, Sorvari R, Pelttari A, Rytomaa I, Franssila S, Kroon L (1996) Hospital mouth-cleaning aids may cause dental erosion. Spec Care Dent 16:247–250CrossRef Meurman JH, Sorvari R, Pelttari A, Rytomaa I, Franssila S, Kroon L (1996) Hospital mouth-cleaning aids may cause dental erosion. Spec Care Dent 16:247–250CrossRef
80.
go back to reference Miller M, Kearney N (2001) Oral care for patients with cancer: a review of the literature. Cancer Nurs 24:241–254PubMedCrossRef Miller M, Kearney N (2001) Oral care for patients with cancer: a review of the literature. Cancer Nurs 24:241–254PubMedCrossRef
81.
go back to reference Chanques G, Constantin JM, Sauter M, Jung B, Sebbane M, Verzilli D, Lefrant JY, Jaber S (2009) Discomfort associated with under humidified high-flow oxygen therapy in critically ill patients. Intensive Care Med 35:996–1003PubMedCrossRef Chanques G, Constantin JM, Sauter M, Jung B, Sebbane M, Verzilli D, Lefrant JY, Jaber S (2009) Discomfort associated with under humidified high-flow oxygen therapy in critically ill patients. Intensive Care Med 35:996–1003PubMedCrossRef
82.
go back to reference Engstrom A, Soderberg S (2004) The experiences of partners of critically ill persons in an intensive care unit. Intensive Crit Care Nurs 20:299–308PubMedCrossRef Engstrom A, Soderberg S (2004) The experiences of partners of critically ill persons in an intensive care unit. Intensive Crit Care Nurs 20:299–308PubMedCrossRef
83.
go back to reference Chien WT, Chiu YL, Lam LW, Ip WY (2006) Effects of a needs-based education programme for family carers with a relative in an intensive care unit: a quasi-experimental study. Int J Nurs Stud 43:39–50PubMedCrossRef Chien WT, Chiu YL, Lam LW, Ip WY (2006) Effects of a needs-based education programme for family carers with a relative in an intensive care unit: a quasi-experimental study. Int J Nurs Stud 43:39–50PubMedCrossRef
84.
go back to reference Hammond F (1995) Involving families in care within the intensive care environment: a descriptive survey. Intensive Crit Care Nurs 11:256–264PubMedCrossRef Hammond F (1995) Involving families in care within the intensive care environment: a descriptive survey. Intensive Crit Care Nurs 11:256–264PubMedCrossRef
85.
go back to reference McAdam JL, Arai S, Puntillo KA (2008) Unrecognized contributions of families in the intensive care unit. Intensive Care Med 34:1097–1101PubMedCrossRef McAdam JL, Arai S, Puntillo KA (2008) Unrecognized contributions of families in the intensive care unit. Intensive Care Med 34:1097–1101PubMedCrossRef
86.
go back to reference Azoulay E, Pochard F, Chevret S, Arich C, Brivet F, Brun F, Charles PE, Desmettre T, Dubois D, Galliot R, Garrouste-Orgeas M, Goldgran-Toledano D, Herbecq P, Joly LM, Jourdain M, Kaidomar M, Lepape A, Letellier N, Marie O, Page B, Parrot A, Rodie-Talbere PA, Sermet A, Tenaillon A, Thuong M, Tulasne P, Le Gall JR, Schlemmer B (2003) Family participation in care to the critically ill: opinions of families and staff. Intensive Care Med 29:1498–1504PubMedCrossRef Azoulay E, Pochard F, Chevret S, Arich C, Brivet F, Brun F, Charles PE, Desmettre T, Dubois D, Galliot R, Garrouste-Orgeas M, Goldgran-Toledano D, Herbecq P, Joly LM, Jourdain M, Kaidomar M, Lepape A, Letellier N, Marie O, Page B, Parrot A, Rodie-Talbere PA, Sermet A, Tenaillon A, Thuong M, Tulasne P, Le Gall JR, Schlemmer B (2003) Family participation in care to the critically ill: opinions of families and staff. Intensive Care Med 29:1498–1504PubMedCrossRef
87.
go back to reference Mitchell M, Chaboyer W, Burmeister E, Foster M (2009) Positive effects of a nursing intervention on family-centered care in adult critical care. Am J Crit Care 18:543–552PubMedCrossRef Mitchell M, Chaboyer W, Burmeister E, Foster M (2009) Positive effects of a nursing intervention on family-centered care in adult critical care. Am J Crit Care 18:543–552PubMedCrossRef
88.
go back to reference Gelinas C (2010) Nurses’ evaluations of the feasibility and the clinical utility of the critical-care pain observation tool. Pain Manag Nurs 11:115–125PubMedCrossRef Gelinas C (2010) Nurses’ evaluations of the feasibility and the clinical utility of the critical-care pain observation tool. Pain Manag Nurs 11:115–125PubMedCrossRef
89.
go back to reference Erdek MA, Pronovost PJ (2004) Improving assessment and treatment of pain in the critically ill. Int J Qual Health Care 16:59–64PubMedCrossRef Erdek MA, Pronovost PJ (2004) Improving assessment and treatment of pain in the critically ill. Int J Qual Health Care 16:59–64PubMedCrossRef
91.
go back to reference Pronovost PJ, Berenholtz SM, Needham DM (2008) Translating evidence into practice: a model for large scale knowledge translation. BMJ 337:a1714PubMedCrossRef Pronovost PJ, Berenholtz SM, Needham DM (2008) Translating evidence into practice: a model for large scale knowledge translation. BMJ 337:a1714PubMedCrossRef
92.
go back to reference Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, Bander J, Kepros J, Goeschel C (2006) An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 355:2725–2732PubMedCrossRef Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, Bander J, Kepros J, Goeschel C (2006) An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 355:2725–2732PubMedCrossRef
93.
go back to reference Pronovost P, Berenholtz S, Dorman T, Lipsett PA, Simmonds T, Haraden C (2003) Improving communication in the ICU using daily goals. J Crit Care 18:71–75PubMedCrossRef Pronovost P, Berenholtz S, Dorman T, Lipsett PA, Simmonds T, Haraden C (2003) Improving communication in the ICU using daily goals. J Crit Care 18:71–75PubMedCrossRef
94.
go back to reference Gay EB, Weiss SP, Nelson JE (2012) Integrating palliative care with intensive care for critically ill patients with lung cancer. Ann Intensive Care 2:3PubMedCentralPubMedCrossRef Gay EB, Weiss SP, Nelson JE (2012) Integrating palliative care with intensive care for critically ill patients with lung cancer. Ann Intensive Care 2:3PubMedCentralPubMedCrossRef
95.
go back to reference Gurses AP, Kim G, Martinez EA, Marsteller J, Bauer L, Lubomski LH, Pronovost PJ, Thompson D (2012) Identifying and categorising patient safety hazards in cardiovascular operating rooms using an interdisciplinary approach: a multisite study. BMJ Qual Saf 21:810–818PubMedCrossRef Gurses AP, Kim G, Martinez EA, Marsteller J, Bauer L, Lubomski LH, Pronovost PJ, Thompson D (2012) Identifying and categorising patient safety hazards in cardiovascular operating rooms using an interdisciplinary approach: a multisite study. BMJ Qual Saf 21:810–818PubMedCrossRef
96.
go back to reference Mularski RA, Curtis JR, Billings JA, Burt R, Byock I, Fuhrman C, Mosenthal AC, Medina J, Ray DE, Rubenfeld GD, Schneiderman LJ, Treece PD, Truog RD, Levy MM (2006) Proposed quality measures for palliative care in the critically ill: a consensus from the Robert Wood Johnson Foundation critical care workgroup. Crit Care Med 34:S404–S411PubMedCrossRef Mularski RA, Curtis JR, Billings JA, Burt R, Byock I, Fuhrman C, Mosenthal AC, Medina J, Ray DE, Rubenfeld GD, Schneiderman LJ, Treece PD, Truog RD, Levy MM (2006) Proposed quality measures for palliative care in the critically ill: a consensus from the Robert Wood Johnson Foundation critical care workgroup. Crit Care Med 34:S404–S411PubMedCrossRef
98.
go back to reference Downie WW, Leatham PA, Rhind VM, Wright V, Branco JA, Anderson JA (1978) Studies with pain rating scales. Ann Rheum Dis 37:378–381PubMedCrossRef Downie WW, Leatham PA, Rhind VM, Wright V, Branco JA, Anderson JA (1978) Studies with pain rating scales. Ann Rheum Dis 37:378–381PubMedCrossRef
99.
go back to reference Jensen MP, Karoly P, Braver S (1986) The measurement of clinical pain intensity: a comparison of six methods. Pain 27:117–126PubMedCrossRef Jensen MP, Karoly P, Braver S (1986) The measurement of clinical pain intensity: a comparison of six methods. Pain 27:117–126PubMedCrossRef
101.
go back to reference Nelson JE, Meier DE, Litke A, Natale DA, Siegel RE, Morrison RS (2004) The symptom burden of chronic critical illness. Crit Care Med 32:1527–1534PubMedCrossRef Nelson JE, Meier DE, Litke A, Natale DA, Siegel RE, Morrison RS (2004) The symptom burden of chronic critical illness. Crit Care Med 32:1527–1534PubMedCrossRef
102.
go back to reference Futier E, Chanques G, Cayot Constantin S, Vernis L, Barres A, Guerin R, Chartier C, Perbet S, Petit A, Jabaudon M, Bazin JE, Constantin JM (2012) Influence of opioid choice on mechanical ventilation duration and ICU length of stay. Minerva Anestesiol 78:46–53PubMed Futier E, Chanques G, Cayot Constantin S, Vernis L, Barres A, Guerin R, Chartier C, Perbet S, Petit A, Jabaudon M, Bazin JE, Constantin JM (2012) Influence of opioid choice on mechanical ventilation duration and ICU length of stay. Minerva Anestesiol 78:46–53PubMed
103.
go back to reference Chaveron D, Silva S, Sanchez-Verlaan P, Conil JM, Sommet A, Geeraerts T, Genestal M, Minville V, Fourcade O (2012) The 90% effective dose of a sufentanil bolus for the management of painful positioning in intubated patients in the ICU. Eur J Anaesthesiol 29:280–285PubMedCrossRef Chaveron D, Silva S, Sanchez-Verlaan P, Conil JM, Sommet A, Geeraerts T, Genestal M, Minville V, Fourcade O (2012) The 90% effective dose of a sufentanil bolus for the management of painful positioning in intubated patients in the ICU. Eur J Anaesthesiol 29:280–285PubMedCrossRef
108.
go back to reference Schwartzstein RM, Lahive K, Pope A, Weinberger SE, Weiss JW (1987) Cold facial stimulation reduces breathlessness induced in normal subjects. Am Rev Respir Dis 136:58–61PubMedCrossRef Schwartzstein RM, Lahive K, Pope A, Weinberger SE, Weiss JW (1987) Cold facial stimulation reduces breathlessness induced in normal subjects. Am Rev Respir Dis 136:58–61PubMedCrossRef
109.
go back to reference Truog RD, Campbell ML, Curtis JR et al (2008) Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College [corrected] of Critical Care Medicine. Crit Care Med 36(3):953–963PubMedCrossRef Truog RD, Campbell ML, Curtis JR et al (2008) Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College [corrected] of Critical Care Medicine. Crit Care Med 36(3):953–963PubMedCrossRef
Metadata
Title
Palliative care in the ICU: relief of pain, dyspnea, and thirst—A report from the IPAL-ICU Advisory Board
Authors
Kathleen Puntillo
Judith Eve Nelson
David Weissman
Randall Curtis
Stefanie Weiss
Jennifer Frontera
Michelle Gabriel
Ross Hays
Dana Lustbader
Anne Mosenthal
Colleen Mulkerin
Daniel Ray
Rick Bassett
Renee Boss
Karen Brasel
Margaret Campbell
Publication date
01-02-2014
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 2/2014
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-013-3153-z

Other articles of this Issue 2/2014

Intensive Care Medicine 2/2014 Go to the issue

Imaging in Intensive Care Medicine

A dangerous percutaneous dilatational tracheostomy