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01-03-2014 | Year in Review 2013

Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients

Authors: Elie Azoulay, Giuseppe Citerio, Jan Bakker, Matteo Bassetti, Dominique Benoit, Maurizio Cecconi, J. Randall Curtis, Glenn Hernandez, Margaret Herridge, Samir Jaber, Michael Joannidis, Laurent Papazian, Mark Peters, Pierre Singer, Martin Smith, Marcio Soares, Antoni Torres, Antoine Vieillard-Baron, Jean-François Timsit

Published in: Intensive Care Medicine | Issue 3/2014

Excerpt

Intensive Care Medicine has taken part this year in the ongoing controversy about sedation strategies for the critically ill. Shehabi et al. [1] replicated the ANZ SPICE study design in 11 Malaysian ICUs to assess whether early sedation depth was independently associated with delayed extubation and increased mortality. They performed a prospective multicenter study that included 259 medical/surgical patients who were sedated and ventilated for at least 24 h. Deep sedation, defined as Richmond Agitation Sedation Score (RASS) ≤ −3, occurred in 71 % of patients at first assessment. Multivariable Cox proportional hazard regression analysis adjusting for confounders confirmed that early deep sedation was independently associated with longer time to extubation, hospital and 180-day mortality. Delirium occurred in 114 (44 %) of patients but was not associated with sedation length upon first assessment. The performance and the feasibility of an automated administration of sedation were evaluated in a phase II randomized controlled trial (RCT) by Le Guen et al. [2]. Thirty-one patients were allocated to receive either propofol or remifentanil, through either an automated or a manual system. In the two groups, targeted bispectral index (BIS) values were between 40 and 60. Propofol consumption was reduced by 50 % in the automated group with a median change of infusion rates of 39 ± 9 times per hour compared to only 2 ± 1 propofol dose changes per hour in the manual group. Similarly, the median number of changes in infusion rates was 40 ± 9 for remifentanil in the automated group, compared to 1 ± 1 dose changes per hour in the manual group. In a single-center pilot study of critically ill patients in spontaneous ventilation undergoing flexible fiberoptic bronchoscopy, the safety and efficacy of sedation with remifentanil target-controlled infusion (Remi-TCI) were assessed by Chalumeau-Lemoine et al. [3]. The procedure was successful, comfortable, and safe in all patients. Patients reported low level of pain and good satisfaction with the procedure. …

Shehabi Y, Chan L, Kadiman S et al (2013) Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med 39:910–918. doi:10.1007/s00134-013-2830-2 PubMedCentralPubMedCrossRef

Le Guen M, Liu N, Bourgeois E et al (2013) Automated sedation outperforms manual administration of propofol and remifentanil in critically ill patients with deep sedation: a randomized phase II trial. Intensive Care Med 39:454–462. doi:10.1007/s00134-012-2762-2 PubMedCrossRef

Chalumeau-Lemoine L, Stoclin A, Billard V et al (2013) Flexible fiberoptic bronchoscopy and remifentanil target-controlled infusion in ICU: a preliminary study. Intensive Care Med 39:53–58. doi:10.1007/s00134-012-2697-7 PubMedCrossRef

Zaal IJ, Spruyt CF, Peelen LM et al (2013) Intensive care unit environment may affect the course of delirium. Intensive Care Med 39:481–488. doi:10.1007/s00134-012-2726-6 PubMedCrossRef

Wolters AE, Slooter AJC, van der Kooi AW, van Dijk D (2013) Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 39:376–386. doi:10.1007/s00134-012-2784-9 PubMedCrossRef

Perren A, Brochard L (2013) Managing the apparent and hidden difficulties of weaning from mechanical ventilation. Intensive Care Med 39:1885–1895. doi:10.1007/s00134-013-3014-9 PubMedCrossRef

Sulemanji DS, Marchese A, Wysocki M, Kacmarek RM (2013) Adaptive support ventilation with and without end-tidal CO2 closed loop control versus conventional ventilation. Intensive Care Med 39:703–710. doi:10.1007/s00134-012-2742-6 PubMedCrossRef

Lellouche F, Bouchard P-A, Simard S et al (2013) Evaluation of fully automated ventilation: a randomized controlled study in post-cardiac surgery patients. Intensive Care Med 39:463–471. doi:10.1007/s00134-012-2799-2 PubMedCrossRef

Alexopoulou C, Kondili E, Plataki M, Georgopoulos D (2013) Patient-ventilator synchrony and sleep quality with proportional assist and pressure support ventilation. Intensive Care Med 39:1040–1047. doi:10.1007/s00134-013-2850-y PubMedCrossRef

10.

Blankman P, Hasan D, van Mourik MS, Gommers D (2013) Ventilation distribution measured with EIT at varying levels of pressure support and neurally adjusted ventilatory assist in patients with ALI. Intensive Care Med 39:1057–1062. doi:10.1007/s00134-013-2898-8 PubMedCrossRef

11.

Chiumello D, Coppola S, Froio S et al (2013) Noninvasive ventilation in chest trauma: systematic review and meta-analysis. Intensive Care Med 39:1171–1180. doi:10.1007/s00134-013-2901-4 PubMedCrossRef

12.

Mojoli F, Iotti GA, Curro I et al (2013) An optimized set-up for helmet noninvasive ventilation improves pressure support delivery and patient-ventilator interaction. Intensive Care Med 39:38–44. doi:10.1007/s00134-012-2686-x PubMedCrossRef

13.

Richard JCM, Lyazidi A, Akoumianaki E et al (2013) Potentially harmful effects of inspiratory synchronization during pressure preset ventilation. Intensive Care Med 39:2003–2010. doi:10.1007/s00134-013-3032-7 PubMedCrossRef

14.

Caldarelli V, Borel JC, Khirani S et al (2013) Polygraphic respiratory events during sleep with noninvasive ventilation in children: description, prevalence, and clinical consequences. Intensive Care Med 39:739–746. doi:10.1007/s00134-012-2806-7 PubMedCrossRef

15.

Carlucci A, Schreiber A, Mattei A et al (2013) The configuration of bi-level ventilator circuits may affect compensation for non-intentional leaks during volume-targeted ventilation. Intensive Care Med 39:59–65. doi:10.1007/s00134-012-2696-8 PubMedCrossRef

16.

Lellouche F, Lipes J (2013) Prophylactic protective ventilation: lower tidal volumes for all critically ill patients? Intensive Care Med 39:6–15. doi:10.1007/s00134-012-2728-4 PubMedCrossRef

17.

Waisman D, Faingersh A, Levy C et al (2013) Transient decrease in PaCO2 and asymmetric chest wall dynamics in early progressing pneumothorax. Intensive Care Med 39:137–145. doi:10.1007/s00134-012-2749-z PubMedCrossRef

18.

Matamis D, Soilemezi E, Tsagourias M et al (2013) Sonographic evaluation of the diaphragm in critically ill patients. Technique and clinical applications. Intensive Care Med 39:801–810. doi:10.1007/s00134-013-2823-1 PubMedCrossRef

19.

Schmidt M, Kindler F, Gottfried SB et al (2013) Dyspnea and surface inspiratory electromyograms in mechanically ventilated patients. Intensive Care Med 39:1368–1376. doi:10.1007/s00134-013-2910-3 PubMedCrossRef

20.

Scales DC (2013) What’s new with tracheostomy? Intensive Care Med 39:1005–1008. doi:10.1007/s00134-013-2904-1 PubMedCrossRef

21.

Blot F, Similowski T, Trouillet J-L et al (2008) Early tracheotomy versus prolonged endotracheal intubation in unselected severely ill ICU patients. Intensive Care Med 34:1779–1787. doi:10.1007/s00134-008-1195-4 PubMedCrossRef

22.

Terragni PP, Antonelli M, Fumagalli R et al (2010) Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients: a randomized controlled trial. JAMA 303:1483. doi:10.1001/jama.2010.447 PubMedCrossRef

23.

Trouillet J-L, Luyt C-E, Guiguet M et al (2011) Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated Patients after cardiac surgery: a randomized trial. Ann Intern Med 154:373. doi:10.7326/0003-4819-154-6-201103150-00002 PubMedCrossRef

24.

Young D, Harrison DA, Cuthbertson BH et al (2013) Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial. JAMA 309:2121. doi:10.1001/jama.2013.5154 PubMedCrossRef

25.

Braune S, Kienast S, Hadem J et al (2013) Safety of percutaneous dilatational tracheostomy in patients on extracorporeal lung support. Intensive Care Med 39:1792–1799. doi:10.1007/s00134-013-3023-8 PubMedCrossRef

26.

Hernandez G, Pedrosa A, Ortiz R et al (2013) The effects of increasing effective airway diameter on weaning from mechanical ventilation in tracheostomized patients: a randomized controlled trial. Intensive Care Med 39:1063–1070. doi:10.1007/s00134-013-2870-7 PubMedCrossRef

27.

Jong A, Clavieras N, Conseil M et al (2013) Implementation of a combo videolaryngoscope for intubation in critically ill patients: a before–after comparative study. Intensive Care Med 39:2144–2152. doi:10.1007/s00134-013-3099-1 PubMedCrossRef

28.

Touat L, Fournier C, Ramon P et al (2013) Intubation-related tracheal ischemic lesions: incidence, risk factors, and outcome. Intensive Care Med 39:575–582. doi:10.1007/s00134-012-2750-6 PubMedCrossRef

29.

Nseir S, Zerimech F, Fournier C et al (2011) Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically Ill patients. Am J Respir Crit Care Med 184:1041–1047. doi:10.1164/rccm.201104-0630OC PubMedCrossRef

30.

Ferguson ND, Fan E, Camporota L et al (2012) The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med 38:1573–1582. doi:10.1007/s00134-012-2682-1 PubMedCrossRef

31.

Hernu R, Wallet F, Thiollière F et al (2013) An attempt to validate the modification of the American-European consensus definition of acute lung injury/acute respiratory distress syndrome by the Berlin definition in a university hospital. Intensive Care Med 39:2161–2170. doi:10.1007/s00134-013-3122-6 PubMedCrossRef

32.

Villar J, Perez-Mendez L, Blanco J et al (2013) A universal definition of ARDS: the PaO2/FiO(2) ratio under a standard ventilatory setting-a prospective, multicenter validation study. Intensive Care Med 39:583–592. doi:10.1007/s00134-012-2803-x PubMedCrossRef

33.

Chiumello D, Coppola S, Froio S et al (2013) Time to reach a new steady state after changes of positive end expiratory pressure. Intensive Care Med 39:1377–1385. doi:10.1007/s00134-013-2969-x PubMedCrossRef

34.

Adamzik M, Broll J, Steinmann J et al (2013) An increased alveolar CD4+CD25+Foxp3+T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality. Intensive Care Med 39:1743–1751. doi:10.1007/s00134-013-3036-3 PubMedCrossRef

35.

Jalkanen V, Yang R, Linko R et al (2013) SuPAR and PAI-1 in critically ill, mechanically ventilated patients. Intensive Care Med 39:489–496. doi:10.1007/s00134-012-2730-x PubMedCrossRef

36.

Fernandez R, Gili G, Villagra A et al (2013) Assessment of the inflammatory effect of low-dose oxygen in mechanically ventilated patients. Intensive Care Med 39:711–716. doi:10.1007/s00134-012-2801-z PubMedCrossRef

37.

Chiumello D, Marino A, Brioni M et al (2013) Visual anatomical lung CT scan assessment of lung recruitability. Intensive Care Med 39:66–73. doi:10.1007/s00134-012-2707-9 PubMedCrossRef

38.

Gutierrez G, Das A, Ballarino G et al (2013) Decreased respiratory rate variability during mechanical ventilation is associated with increased mortality. Intensive Care Med 39:1359–1367. doi:10.1007/s00134-013-2937-5 PubMedCrossRef

39.

Deye N, Lellouche F, Maggiore SM et al (2013) The semi-seated position slightly reduces the effort to breathe during difficult weaning. Intensive Care Med 39:85–92. doi:10.1007/s00134-012-2727-5 PubMedCrossRef

40.

Gattinoni L, Pesenti A, Carlesso E (2013) Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure: impact and clinical fallout through the following 20 years. Intensive Care Med 39:1909–1915. doi:10.1007/s00134-013-3066-x PubMedCrossRef

41.

Bein T, Weber-Carstens S, Goldmann A et al (2013) Lower tidal volume strategy (approximate to 3 ml/kg) combined with extracorporeal CO2 removal versus “conventional” protective ventilation (6 ml/kg) in severe ARDS. Intensive Care Med 39:847–856. doi:10.1007/s00134-012-2787-6 PubMedCentralPubMedCrossRef

42.

Mauri T, Bellani G, Grasselli G et al (2013) Patient-ventilator interaction in ARDS patients with extremely low compliance undergoing ECMO: a novel approach based on diaphragm electrical activity. Intensive Care Med 39:282–291. doi:10.1007/s00134-012-2755-1 PubMedCrossRef

43.

Schmidt M, Tachon G, Devilliers C et al (2013) Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults. Intensive Care Med 39:838–846. doi:10.1007/s00134-012-2785-8 PubMedCrossRef

44.

Schmidt M, Zogheib E, Roze H et al (2013) The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Intensive Care Med 39:1704–1713. doi:10.1007/s00134-013-3037-2 PubMedCrossRef

45.

Roch A, Hraiech S, Masson E et al (2013) Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center. Intensive Care Med 40:74–83. doi:10.1007/s00134-013-3135-1 PubMedCrossRef

46.

Pappalardo F, Pieri M, Greco T et al (2013) Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med 39:275–281. doi:10.1007/s00134-012-2747-1 PubMedCrossRef

47.

Distelmaier K, Niessner A, Haider D et al (2013) Long-term mortality in patients with chronic obstructive pulmonary disease following extracorporeal membrane oxygenation for cardiac assist after cardiovascular surgery. Intensive Care Med 39:1444–1451. doi:10.1007/s00134-013-2931-y PubMedCrossRef

48.

Al-Soufi S, Buscher H, Nguyen ND et al (2013) Lack of association between body weight and mortality in patients on veno-venous extracorporeal membrane oxygenation. Intensive Care Med 39:1995–2002. doi:10.1007/s00134-013-3028-3 PubMedCrossRef

49.

Ferrie S, Herkes R, Forrest P (2013) Nutrition support during extracorporeal membrane oxygenation (ECMO) in adults: a retrospective audit of 86 patients. Intensive Care Med 39:1989–1994. doi:10.1007/s00134-013-3053-2 PubMedCrossRef

50.

Papazian L, Herridge M (2013) Outcomes and risk stratification for severe ARDS treated with ECMO. Intensive Care Med 39:1857–1860. doi:10.1007/s00134-013-3067-9 PubMedCrossRef

51.

Abrams D, Brodie D, Combes A (2013) What is new in extracorporeal membrane oxygenation for ARDS in adults? Intensive Care Med 39:2028–2030. doi:10.1007/s00134-013-3035-4 PubMedCrossRef

52.

Nesseler N, Defontaine A, Launey Y et al (2013) Long-term mortality and quality of life after septic shock: a follow-up observational study. Intensive Care Med 39:881–888. doi:10.1007/s00134-013-2815-1 PubMedCrossRef

53.

Oeyen SG, Benoit DD, Annemans L et al (2013) Long-term outcomes and quality of life in critically ill patients with hematological or solid malignancies: a single center study. Intensive Care Med 39:889–898. doi:10.1007/s00134-012-2791-x PubMedCrossRef

54.

Azoulay E, Kouatchet A, Jaber S et al (2013) Noninvasive mechanical ventilation in patients having declined tracheal intubation. Intensive Care Med 39:292–301. doi:10.1007/s00134-012-2746-2 PubMedCrossRef

55.

Jongerden IP, Slooter AJ, Peelen LM et al (2013) Effect of intensive care environment on family and patient satisfaction: a before-after study. Intensive Care Med 39:1626–1634. doi:10.1007/s00134-013-2966-0 PubMedCrossRef

56.

Schwarzkopf D, Behrend S, Skupin H et al (2013) Family satisfaction in the intensive care unit: a quantitative and qualitative analysis. Intensive Care Med 39:1071–1079. doi:10.1007/s00134-013-2862-7 PubMedCrossRef

57.

Jones C (2013) What’s new on the post-ICU burden for patients and relatives? Intensive Care Med 39:1832–1835. doi:10.1007/s00134-013-3015-8 PubMedCrossRef

58.

Giannini A, Miccinesi G, Prandi E et al (2013) Partial liberalization of visiting policies and ICU staff: a before-and-after study. Intensive Care Med 39:2180–2187. doi:10.1007/s00134-013-3087-5

59.

Philippart F, Vesin A, Bruel C et al (2013) The ETHICA study (part I): elderly’s thoughts about intensive care unit admission for life-sustaining treatments. Intensive Care Med 39:1565–1573. doi:10.1007/s00134-013-2976-y PubMedCrossRef

60.

Garrouste-Orgeas M, Tabah A, Vesin A et al (2013) The ETHICA study (part II): simulation study of determinants and variability of ICU physician decisions in patients aged 80 or over. Intensive Care Med 39:1574–1583. doi:10.1007/s00134-013-2977-x PubMedCrossRef

61.

Wilson ME, Rhudy LM, Ballinger BA et al (2013) Factors that contribute to physician variability in decisions to limit life support in the ICU: a qualitative study. Intensive Care Med 39:1009–1018. doi:10.1007/s00134-013-2896-x PubMedCrossRef

62.

Barnato AE, Tate JA, Rodriguez KL et al (2012) Norms of decision making in the ICU: a case study of two academic medical centers at the extremes of end-of-life treatment intensity. Intensive Care Med 38:1886–1896. doi:10.1007/s00134-012-2661-6 PubMedCentralPubMedCrossRef

63.

Kutsogiannis DJ, Asthana S, Townsend DR et al (2013) The incidence of potential missed organ donors in intensive care units and emergency rooms: a retrospective cohort. Intensive Care Med 39:1452–1459. doi:10.1007/s00134-013-2952-6 PubMedCrossRef

64.

Al-Khafaji A, Murugan R, Kellum JA (2013) What’s new in organ donation: better care of the dead for the living. Intensive Care Med 39:2031–2033. doi:10.1007/s00134-013-3038-1 PubMedCrossRef

65.

Gigon F, Merlani P, Chenaud C, Ricou B (2013) ICU research: the impact of invasiveness on informed consent. Intensive Care Med 39:1282–1289. doi:10.1007/s00134-013-2908-x PubMedCrossRef

66.

Potter JE, McKinley S, Delaney A (2013) Research participants’ opinions of delayed consent for a randomised controlled trial of glucose control in intensive care. Intensive Care Med 39:472–480. doi:10.1007/s00134-012-2732-8 PubMedCrossRef

67.

Kompanje EJO (2013) Strong words, but still a step back for researchers in emergency and critical care research? The proposed revision of the Declaration of Helsinki. Intensive Care Med 39:1469–1470. doi:10.1007/s00134-013-2988-7 PubMedCrossRef

68.

Cook D, Arabi Y, Ferguson N et al (2013) Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis. Intensive Care Med 39:2115–2125. doi:10.1007/s00134-013-3074-x PubMedCrossRef

69.

Sprung CL, Danis M, Iapichino G et al (2013) Triage of intensive care patients: identifying agreement and controversy. Intensive Care Med 39:1916–1924. doi:10.1007/s00134-013-3033-6 PubMedCrossRef

70.

Garrouste-Orgeas M, Valentin A (2013) What’s new for patient safety in the ICU? Intensive Care Med 39:1829–1831. doi:10.1007/s00134-013-3013-x PubMedCrossRef

71.

Valentin A, Schiffinger M, Steyrer J et al (2013) Safety climate reduces medication and dislodgement errors in routine intensive care practice. Intensive Care Med 39:391–398. doi:10.1007/s00134-012-2764-0 PubMedCrossRef

72.

De Jonghe B, Constantin J-M, Chanques G et al (2013) Physical restraint in mechanically ventilated ICU patients: a survey of French practice. Intensive Care Med 39:31–37. doi:10.1007/s00134-012-2715-9 PubMedCrossRef

73.

Pelieu I, Djadi-Prat J, Consoli SM et al (2013) Impact of organizational culture on preventability assessment of selected adverse events in the ICU: evaluation of morbidity and mortality conferences. Intensive Care Med 39:1214–1220. doi:10.1007/s00134-013-2923-y PubMedCrossRef

74.

Ten Have ECM, Nap RE, Tulleken JE (2013) Quality improvement of interdisciplinary rounds by leadership training based on essential quality indicators of the Interdisciplinary Rounds Assessment Scale. Intensive Care Med 39:1800–1807. doi:10.1007/s00134-013-3002-0 PubMedCrossRef

75.

Kahn JM (2013) What’s new in ICU volume-outcome relationships? Intensive Care Med 39:1635–1637. doi:10.1007/s00134-013-2992-y PubMedCrossRef

76.

Latronico N, Metelli M, Turin M et al (2013) Quality of reporting of randomized controlled trials published in Intensive Care Medicine from 2001 to 2010. Intensive Care Med 39:1386–1395. doi:10.1007/s00134-013-2947-3 PubMedCrossRef

77.

Vesin A, Azoulay E, Ruckly S et al (2013) Reporting and handling missing values in clinical studies in intensive care units. Intensive Care Med 39:1396–1404. doi:10.1007/s00134-013-2949-1 PubMedCrossRef

78.

Awissi D-K, Lebrun G, Coursin DB et al (2013) Alcohol withdrawal and delirium tremens in the critically ill: a systematic review and commentary. Intensive Care Med 39:16–30. doi:10.1007/s00134-012-2758-y PubMedCrossRef

79.

Drolz A, Jaeger B, Wewalka M et al (2013) Clinical impact of arterial ammonia levels in ICU patients with different liver diseases. Intensive Care Med 39:1227–1237. doi:10.1007/s00134-013-2926-8 PubMedCrossRef

80.

Thiolliere F, Serre-Sapin AF, Reignier J et al (2013) Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study. Intensive Care Med 39:1460–1468. doi:10.1007/s00134-013-2963-3 PubMedCrossRef

81.

De Blasi RA, Cardelli P, Costante A et al (2013) Immature platelet fraction in predicting sepsis in critically ill patients. Intensive Care Med 39:636–643. doi:10.1007/s00134-012-2725-7 PubMedCrossRef

82.

Mariotte E, Blet A, Galicier L et al (2013) Unresponsive thrombotic thrombocytopenic purpura in critically ill adults. Intensive Care Med 39:1272–1281. doi:10.1007/s00134-013-2873-4 PubMedCrossRef

83.

Vincent J-L, Hajjar LA (2013) What’s new in transfusion policies? Intensive Care Med 39:1002–1004. doi:10.1007/s00134-013-2900-5 PubMedCrossRef

84.

Kahn SR (2012) Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. CHEST J 141:e195S. doi:10.1378/chest.11-2296 CrossRef

85.

Vignon P, Dequin P-F, Renault A et al (2013) Intermittent pneumatic compression to prevent venous thromboembolism in patients with high risk of bleeding hospitalized in intensive care units: the CIREA1 randomized trial. Intensive Care Med 39:872–880. doi:10.1007/s00134-013-2814-2 PubMedCrossRef

86.

Matějková S, Scheuerle A, Wagner F et al (2013) Carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine kidney ischemia/reperfusion injury. Intensive Care Med 39:497–510. doi:10.1007/s00134-012-2766-y PubMedCrossRef

87.

Mesgarpour B, Heidinger BH, Schwameis M et al (2013) Safety of off-label erythropoiesis stimulating agents in critically ill patients: a meta-analysis. Intensive Care Med 39:1896–1908. doi:10.1007/s00134-013-3030-9 PubMedCrossRef

Title: Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients
Authors: Elie Azoulay
Giuseppe Citerio
Jan Bakker
Matteo Bassetti
Dominique Benoit
Maurizio Cecconi
J. Randall Curtis
Glenn Hernandez
Margaret Herridge
Samir Jaber
Michael Joannidis
Laurent Papazian
Mark Peters
Pierre Singer
Martin Smith
Marcio Soares
Antoni Torres
Antoine Vieillard-Baron
Jean-François Timsit
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 3/2014
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3217-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients

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Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

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