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Intensive Care Medicine
Published in: Intensive Care Medicine 8/2014

01-08-2014 | My Paper 20 Years Later

Weaning-induced cardiac dysfunction: where are we today?

Author: Jean-Louis Teboul

Published in: Intensive Care Medicine | Issue 8/2014

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Abstract

Introduction

The concept of weaning-induced cardiac dysfunction emerged 26 years ago with the publication of a clinical study conducted by François Lemaire and collaborators.

Objectives

One objective of this article is to remember the results and the historical context under which our pivotal study was conducted. Another objective is to review some of the subsequent studies that aimed to analyze the underlying mechanisms, to noninvasively detect the cardiac origin of weaning failure, and to propose specific therapies enabling weaning success.

Conclusion

Weaning-induced cardiac dysfunction has become an established cause of weaning failure. Underlying mechanisms may differ from one patient to another. Important progress has already been made in its diagnosis thanks to relevant clinical research studies. Ongoing and future technological advances in ultrasonography and in biomarker research should certainly help in diagnosing weaning induced-pulmonary edema and in identifying the main mechanisms responsible for its development. Progress on appropriate therapeutic options on an individual basis is still expected.
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Metadata
Title
Weaning-induced cardiac dysfunction: where are we today?
Author
Jean-Louis Teboul
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 8/2014
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-014-3334-4

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