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Intensive Care Medicine

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01-03-2011 | Original

B-type natriuretic peptides for prediction and diagnosis of weaning failure from cardiac origin

Authors: Lluís Zapata, Paula Vera, Antoni Roglan, Ignasi Gich, Jordi Ordonez-Llanos, Antoni J. Betbesé

Published in: Intensive Care Medicine | Issue 3/2011

Abstract

Aim

To evaluate and compare BNP and NT-proBNP concentrations to predict weaning failure from mechanical ventilation (MV) due to heart failure (HF) before a spontaneous breathing trial (SBT) and to identify HF as the cause of failure.

Methods

Prospective, observational study in a university hospital. The sample included 100 patients on MV for over 48 h who underwent an SBT. Echocardiography and sampling for natriuretic peptides were performed immediately before and at the end of SBT. HF was diagnosed by pulmonary artery occlusion pressure >18 mm Hg or signs of elevated filling pressures in echocardiography.

Results

Thirty-two patients failed the SBT, 12 due to HF and 20 due to respiratory failure (RF). Before SBT, BNP and NT-proBNP were higher in patients failing due to HF than RF or in successfully weaned patients. Cut-off values using ROC curve analyses to predict HF were 263 ng/L for BNP (p < 0.001) and 1,343 ng/L for NT-proBNP (p = 0.08). BNP and NT-proBNP increased significantly during SBT in patients failing due to HF. Increases in BNP and NT-proBNP of 48 and 21 ng/L, respectively, showed a diagnostic accuracy for HF of 88.9 and 83.3% (p < 0.001). BNP performed better than NT-proBNP for HF prediction (p = 0.01) and diagnosis (p = 0.009).

Conclusion

B-type natriuretic peptides, particularly BNP, can predict weaning failure due to HF before an SBT; increases in natriuretic peptides during SBT are diagnostic of HF as the cause of weaning failure. BNP performs better than NT-proBNP in prediction and diagnosis of HF.

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Title: B-type natriuretic peptides for prediction and diagnosis of weaning failure from cardiac origin
Authors: Lluís Zapata
Paula Vera
Antoni Roglan
Ignasi Gich
Jordi Ordonez-Llanos
Antoni J. Betbesé
Publication date: 01-03-2011
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 3/2011
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-2101-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

B-type natriuretic peptides for prediction and diagnosis of weaning failure from cardiac origin

Abstract

Aim

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Aim

Methods

Results

Conclusion

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