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Intensive Care Medicine

Published in:

01-12-2012 | Pediatric Original

Vitamin D status in critically ill children

Authors: Constance Rippel, Michael South, Warwick W. Butt, Lara S. Shekerdemian

Published in: Intensive Care Medicine | Issue 12/2012

Abstract

Background

Hypovitaminosis D is an independent risk factor for cardiovascular disease, muscle weakness, impaired metabolism, immune dysfunction, and compromised lung function. Hypovitaminosis D is common in critically ill adults and has been associated with adverse outcomes. The prevalence of hypovitaminosis D and its significance in critically ill children are unclear.

Methods

We performed a prospective study to determine the prevalence of hypovitaminosis D in 316 critically ill children, and examined its association with physiological and biochemical variables, length of pediatric intensive care unit (PICU) stay, and hospital mortality.

Results

The prevalence of hypovitaminosis D [25(OH)D₃ <50 nmol/L] was 34.5 %. Hypovitaminosis D was more common in postoperative cardiac patients than in general medical ICU patients (40.5 versus 22.6 %, p = 0.002), and the cardiac patients had a higher inotrope score [2.5 (1.9–3.3) versus 1.4 (1.1–1.9), p = 0.006]. Additionally, ionized calcium within the first 24 h was lower in patients with 25(OH)D₃ <50 nmol/L [1.07 (0.99–1.14) mmol/L] compared with patients with normal vitamin D₃ [1.17 (1.14–1.19) mmol/L, p = 0.02]. Hypovitaminosis D was not associated with longer PICU stay or increased hospital mortality.

Conclusions

Hypovitaminosis D is common in critically ill children, and is associated with higher inotropes in the postoperative cardiac population, but not with PICU length of stay or hospital survival.

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Title: Vitamin D status in critically ill children
Authors: Constance Rippel
Michael South
Warwick W. Butt
Lara S. Shekerdemian
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 12/2012
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-012-2718-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Vitamin D status in critically ill children

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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