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Open Access 01-01-2011 | Original

Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome

Authors: Helge Røsjø, Marjut Varpula, Tor-Arne Hagve, Sari Karlsson, Esko Ruokonen, Ville Pettilä, Torbjørn Omland, The FINNSEPSIS Study Group

Published in: Intensive Care Medicine | Issue 1/2011

Abstract

Purpose

To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis.

Methods

cTnT levels were measured by the novel hs-cTnT assay at two time points (inclusion and 72 h thereafter) in a subgroup of patients from the FINNSEPSIS study and associations with clinical outcomes were examined. Results for the hs-cTnT assay were compared to those of the established fourth-generation cTnT assay.

Results

cTnT measured by the fourth-generation and hs-cTnT assay was detectable in 124 (60%) and 207 (100%) patients, respectively, on inclusion in this study. hs-cTnT levels on inclusion correlated with several indices of risk in sepsis, including the simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores. The level of hs-cTnT on inclusion was higher in hospital non-survivors (n = 47) than survivors (n = 160) (median 0.054 [Q1–3, 0.022–0.227] versus 0.035 [0.015–0.111] μg/L, P = 0.047), but hs-cTnT level was not an independent predictor of in-hospital mortality. hs-cTnT levels on inclusion were also higher in patients with septic shock during the hospitalization (0.044 [0.024–0.171] versus 0.033 [0.012–0.103] μg/L, P = 0.03), while this was not the case for the fourth-generation cTnT assay or NT-proBNP levels.

Conclusions

Circulating hs-cTnT is present in patients with severe sepsis and septic shock, associates with disease severity and survival, but does not add to SAPS II score for prediction of mortality. hs-cTnT measurement could still have a role in sepsis as an early marker of shock.

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Title: Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome
Authors: Helge Røsjø
Marjut Varpula
Tor-Arne Hagve
Sari Karlsson
Esko Ruokonen
Ville Pettilä
Torbjørn Omland
The FINNSEPSIS Study Group
Publication date: 01-01-2011
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 1/2011
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-010-2051-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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