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Intensive Care Medicine
Published in: Intensive Care Medicine 3/2007

01-03-2007 | Original

Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study

Authors: Sari Karlsson, Marjut Varpula, Esko Ruokonen, Ville Pettilä, Ilkka Parviainen, Tero I. Ala-Kokko, Elina Kolho, Esa M. Rintala

Published in: Intensive Care Medicine | Issue 3/2007

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Abstract

Objective

To determine the incidence and outcome of severe sepsis in the adult Finnish population and to evaluate how treatment guidelines in severe sepsis are applied in clinical practice.

Study design

A prospective study in 24 closed multidisciplinary ICUs in 21 hospitals (4 university and 17 tertiary hospitals) in Finland.

Patients

All 4,500 consecutive ICU admission episodes were screened for severe sepsis during a 4-month period (1 November 2004 – 28 February 2005). The referral population was 3,743,225.

Results

The severe sepsis criteria were fulfilled in 470 patients, who had472 septic episodes. The incidence of severe sepsis in the ICUs in Finland was 0.38/1000 in the adult population (95% confidence interval 0.34–0.41). The mean ICU length of stay was 8.2 ± 8.1 days. ICU, hospital, and 1-year mortality rates were 15.5%, 28.3%, and 40.9%, respectively. Respiratory failure requiring ventilation support was the most common organ failure (86.2%); septic shock was present in 77% and acute renal failure in 20.6% of cases. Activated protein C was given to only 15 of the 55 patients with indication (27%) and low-dose corticosteroids to 150 of 366 (41%) patients with septic shock.

Conclusions

This prospective study found the incidence of ICU-treated severe sepsis in Finland to be 0.38 per 1,000 of the population. The ICU and hospital mortalities were also lower than earlier reported in United States or Australia. Evidence-based sepsis therapies were not used as often as recommended.
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Metadata
Title
Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study
Authors
Sari Karlsson
Marjut Varpula
Esko Ruokonen
Ville Pettilä
Ilkka Parviainen
Tero I. Ala-Kokko
Elina Kolho
Esa M. Rintala
Publication date
01-03-2007
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 3/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-006-0504-z

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